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11S/12S proglobulin + H2O
?
-
-
-
-
?
Ac-Asp-Asn-Leu-Asp alpha-(4-methylcoumaryl-7-amide) + H2O
Ac-Asp-Asn-Leu-Asp + 7-amino-4-methylcoumarin
-
-
-
?
Ac-Tyr-Val-Ala-Asp-4-nitroanilide + H2O
?
-
-
-
?
acetoacetyl-CoA synthetase + H2O
?
acetyl-Pro-Thr-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Pro-Thr-Asn + 7-amino-4-methylcoumarin
acetyl-Thr-Ala-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Thr-Ala-Asn + 7-amino-4-methylcoumarin
acetyl-Tyr-Val-Ala-Asp-4-methylcoumarin-7-amide + H2O
acetyl-Tyr-Val-Ala-Asp + 7-amino-4-methylcoumarin
AGTHNGQIGA + H2O
AGTHN + GQIGA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived, low activity
-
?
AHIDNEEDIA + H2O
AHIDN + EEDIA
-
low activity, the peptide sequence is also cleaved in tetanus toxoid C fragment of which it is derived
-
?
AHIDNESDIA + H2O
AHIDN + ESDIA
-
low activity
-
?
Albumin + H2O
?
-
-
-
-
?
ALKGNNLIWA + H2O
ALKGN + NLIWA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
allatotropin + H2O
?
-
-
-
?
annexin A2 + H2O
?
-
-
-
-
?
annexin II + H2O
?
cleavage of the N-terminus, enzyme plays a role in inactivation and degradation of annexin II in endosomes and lysosomes
-
?
AQLKNITDYA + H2O
AQLKN + ITDYA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
AREDNNITLA + H2O
AREDN + NITLA
-
low activity, the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
ARLYNGLKFA + H2O
ARLYN + GLKFA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
ASGFNSSVIA + H2O
ASGFN + SSVIA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
ATITNDRLSA + H2O
ATITN + DLRSA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
AYGTNEYSIA + H2O
AYGTN + EYSIA
-
the peptide sequence is not cleaved in tetanus toxoid C fragment of which it is derived
-
?
azocasein + H2O
?
-
-
-
?
azocasein + H2O
fragments of azocasein
-
-
-
?
benzoyl-Asn-4-nitroanilide + H2O
benzoyl-Asn + 4-nitroaniline
benzoyl-L-Arg-4-nitroanilide + H2O
?
-
-
-
?
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn + 7-amino-4-methylcoumarin
Benzyloxycarbonyl-Ala 4-nitrophenyl ester + H2O
Benzyloxycarbonyl-Ala + 4-nitrophenol
-
-
-
?
Benzyloxycarbonyl-Ala-Ala-Asn 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcouamrin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Ala-Ala-Asp-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asp + 7-amino-4-methylcoumarin
the canonical Asn P1 specificity is only observed at pH 6.0, whereas a decrease in pH to 5.0 or even 4.0 results in a substantially increased number of cleavages of which almost half are after Asp
-
-
?
benzyloxycarbonyl-Ala-Glu-Asn-Xaa-Ala-Glu-Lys-NH2 + H2O
benzyloxycarbonyl-Ala-Glu-Asn + Xaa-Ala-Glu-Lys-NH2
-
substrate specificity at S1 position, overview
-
?
Benzyloxycarbonyl-Ala-Pro-Asn 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Benzyloxycarbonyl-Ala-Pro-Tyr-Asn 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Benzyloxycarbonyl-Asn nitrophenyl ester + H2O
Benzyloxycarbonyl-Asn + 4-nitrophenol
-
-
-
?
Benzyloxycarbonyl-Gly 4-nitrophenyl ester + H2O
Benzyloxycarbonyl-Gly + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Gly-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Gly-Ala-Asn + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Ile-Ser-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ile-Ser-Asn + 7-amino-4-methylcoumarin
low activity with
-
?
benzyloxycarbonyl-Leu-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Ala-Asn + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe 4-nitrophenyl ester + H2O
benzyloxycarbonyl-Phe + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Phe-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Ala-Asn + 7-amino-4-methylcoumarin
Benzyloxycarbonyl-Pro-Ala-Asn 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Pro-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Pro-Ala-Asn + 7-amino-4-methylcoumarin
Benzyloxycarbonyl-Tyr 4-nitrophenyl ester + H2O
Benzyloxycarbonyl-Tyr + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Tyr-Ala-Asn + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
Boc-Asn-4-nitrophenyl ester + H2O
Boc-Asn + 4-nitrophenol
bovine albumin + H2O
peptides containing C-terminal Asn
-
-
-
?
bovine collagen types I + H2O
?
-
-
-
?
bovine collagen types II + H2O
?
-
-
-
?
bovine haemoglobin + H2O
peptides containing C-terminal Asn
exhibited strict specificity for the asparaginyl bonds on the carboxy-terminal side of a peptide
-
-
?
bovine serum albumin + H2O
3 fragments
-
SDS-denatured substrate, cleavage site are at positions 324 and 404
-
?
Bovine serum albumin + H2O
?
carbobenzyloxy-Ala-Ala-Asn-ethylenediamine-etoposide + H2O
etoposide-ethylenediamine + carbobenzyloxy-Ala-Ala-Asn
-
legumain releases the chemotherapeutic agent etoposide, as the active drug
-
-
?
casein 1 + H2O
2 fragments
-
cleavage site is at position 95
-
?
cathepsin B + H2O
?
-
-
-
-
?
cathepsin B proform + H2O
activated cathepsin B
cathepsin H + H2O
?
-
-
-
-
?
cathepsin S + H2O
?
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
CBZ-Ala-Ala-Asn-amido-4-methylcoumarin + H2O
CBZ-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-azaAsn-7-amido-4-methyl-coumarin + H2O
?
chicken vasoactive intestinal peptide fragment 16-28 + H2O
?
-
-
-
?
concanavalin A A-chain + H2O
3 fragments
-
cleavage site are at positions 159 and 163
-
?
concanavalin A precursor + H2O
activated concanavalin A
-
internal excision of the propeptide and transpeptidation that leads to the inverted fusion of the 2 fragments of the precursor
-
?
cyclic knottin + H2O
?
-
-
-
-
?
cystatin C + H2O
?
-
-
-
-
?
Dinitrophenyl-Pro-Glu-Ala-Asn-NH2 + H2O
Dinitrophenyl-Pro-Glu-Ala-Asn + NH4OH
Dnp-Pro-Glu-Ala-Asn-NH2 + H2O
Dnp-Pro-Glu-Ala-Asn + NH3
-
-
-
-
?
ETRNGVEE + H2O
ETRN + GVEE
Fibronectin + H2O
?
-
-
-
-
?
Gelatin + H2O
Hydrolyzed gelatin
-
-
-
?
gelatinase + H2O
gelatinase fragment
Gliadin + H2O
?
-
-
-
-
?
globulin + H2O
?
-
-
-
-
?
glutelin + H2O
?
-
-
-
-
?
GSVKAYTNFDAERD + H2O
GSVKAYTN + FDAERD
synthetic peptide, residues24-37, derived from the N-terminal sequence of bovine annexin II, cleavage at position N31-F32
-
?
human vasoactive intestinal peptide fragment 1-12 + H2O
?
-
-
-
?
Kalata-type cyclic peptide + H2O
?
-
-
-
-
?
legumain + H2O
processed legumain + N-terminal and C-terminal prodomains
-
autocatalysis
-
?
lysozyme C + H2O
3 fragments
-
cleavage site are at positions 62 and 64
-
?
myelin basic protein + H2O
?
myelin basic protein MBP + H2O
5 fragments
-
cleavage sites at positions 84-85 and 92-93, multiple-sclerosis-associated autoantigen, digestion, destruction of the immunodominant epitope 83-99
product determination
?
neurotensin fragment 1-11 + H2O
?
-
-
-
?
octapeptides basing on the processing sites of 11S proglobulin + H2O
?
-
-
-
?
papain-like cysteine proteinase precursors + H2O
activated papin-like cysteine proteinases
pig vasoactive intestinal peptide fragment 1-28 + H2O
?
-
-
-
?
precursor of basic vacuolar chitinase + H2O
active basic vacuolar chitinase
proconcanavalin A + H2O
?
-
-
-
-
?
progelatinase A + H2O
?
-
-
-
-
?
progelatinase A + H2O
gelatinase + ?
progelatinase A + H2O
gelatinase A + ?
-
in cell culture of human fibrosarcoma HT1080 cells, 72 kDa proform, activation by cleavage of an asparaginyl peptide bond at Asn109-Tyr110 or Asn111-Phe112 to form the N-terminus of the mature active gelatinase
62 kDa mature form
?
progelatinase A + H2O
gelatinase A + gelatinase A propeptide
Proglycinin + H2O
?
-
cleavage takes place between the conserved Asn and Gly residues
-
-
?
Prolegumin + H2O
?
-
cleavage takes place between the conserved Asn and Gly residues
-
-
?
rat alpha1-macroglobulin + H2O
3 fragments
-
cleavage site are at positions 721 and 899
-
?
recombinant C-fragment of tetanus toxoid + H2O
?
-
cleavage of 3 peptide bonds
-
?
Schistosoma cathepsin B + H2O
?
-
-
-
?
Ser-Glu-Ser-Glu-Asn-Gly-Leu-Glu-Glu-Thr + H2O
Ser-Glu-Ser-Glu-Asn + Gly-Leu-Glu-Glu-Thr
-
-
-
?
serine protease inhibitor precursor + H2O
?
-
-
-
-
?
serum albumin + H2O
?
-
-
?
SESENGLEET + H2O
SESEN + GLEET
somatostatin + H2O
?
-
-
-
?
succinyl-Tyr-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
succinyl-Tyr-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Tau-protein + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Asn nitrophenyl ester + H2O
tert-butoxycarbonyl-Asn + 4-nitrophenol
Tert-Butoxycarbonyl-Gln 4-nitrophenyl ester + H2O
Tert-Butoxycarbonyl-Gln + 4-nitrophenol
-
-
-
?
tetanus toxin + H2O
?
-
-
-
?
Tetanus toxin C-terminal fragment + H2O
?
-
-
-
-
?
tetanus toxoid C fragment + H2O
3 fragments
-
cleavage sites are at Asn26, Asn97, and Asn372, but not Asn337
-
?
tetanus toxoid C fragment + H2O
?
-
cleavage site are at positions 26, 337, and 372
-
?
tetanus toxoid C fragment + H2O
tetanus toxoid fragments
-
cleavage sites are at Asn26, Asn337, and Asn372
-
?
transferrin + H2O
5 fragments
-
cleavage site are at positions 95, 529, 574, and 603
-
?
transferrin + H2O
?
-
-
?
Vasoactive intestinal peptide + H2O
?
-
specific cleavage
-
-
?
Vicilin + H2O
?
-
degradation of the principal reserve protein present in Vigna radiata seeds
-
-
?
Vicilin + H2O
Hydrolyzed vicilin
-
-
-
?
vitamin D-binding protein + H2O
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
Z-Ala-Pro-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Pro-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Z-Ala-Ser-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ser-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Z-ESEN-7-amido-4-methylcoumarin + H2O
Z-ESEN + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Val-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
ZN-alpha2-glycoprotein + H2O
?
-
-
?
additional information
?
-
11S proglobulin + H2O
?
-
degradation of unassembled proteins or misfolded precursors
-
?
11S proglobulin + H2O
?
-
processing to the active trimer
-
?
11S proglobulin + H2O
?
-
degradation of unassembled proteins or misfolded precursors
-
?
11S proglobulin + H2O
?
-
processing to the active trimer
-
?
11S proglobulin + H2O
?
degradation of unassembled proteins or misfolded precursors
-
?
11S proglobulin + H2O
?
processing to the active trimer
-
?
11S proglobulin + H2O
?
-
degradation of unassembled proteins or misfolded precursors
-
?
11S proglobulin + H2O
?
-
processing to the active trimer
-
?
11S proglobulin + H2O
?
-
degradation of unassembled proteins or misfolded precursors
-
?
11S proglobulin + H2O
?
-
processing to the active trimer
-
?
acetoacetyl-CoA synthetase + H2O
?
-
-
-
-
?
acetoacetyl-CoA synthetase + H2O
?
Asn547 is the specific cleavage site of acetoacetyl-CoA synthetase in mouse livers. The cleaved form of acetoacetyl-CoA synthetase (1-547) loses the ability to convert acetoacetate to acetoacetyl-CoA. Cleavage of acetoacetyl-CoA synthetase by legumain is critical for the regulation of enzymatic activity and results in gain-of-function changes. Acetoacetyl-CoA synthetase(1-547) increases the protein expression of caveolin-1, the principal component of the caveolae
-
-
?
acetoacetyl-CoA synthetase + H2O
?
Asn547 is the specific cleavage site of acetoacetyl-CoA synthetase in mouse livers. The cleaved form of acetoacetyl-CoA synthetase (1-547) loses the ability to convert acetoacetate to acetoacetyl-CoA
-
-
?
acetyl-Pro-Thr-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Pro-Thr-Asn + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Pro-Thr-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Pro-Thr-Asn + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Thr-Ala-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Thr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Thr-Ala-Asn-4-methylcoumarin-7-amide + H2O
acetyl-Thr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Tyr-Val-Ala-Asp-4-methylcoumarin-7-amide + H2O
acetyl-Tyr-Val-Ala-Asp + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Tyr-Val-Ala-Asp-4-methylcoumarin-7-amide + H2O
acetyl-Tyr-Val-Ala-Asp + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Asn-4-nitroanilide + H2O
benzoyl-Asn + 4-nitroaniline
Bz-Asn-pNA, recombinant protein, at 37°C
-
-
?
benzoyl-Asn-4-nitroanilide + H2O
benzoyl-Asn + 4-nitroaniline
-
-
-
?
benzoyl-Asn-4-nitroanilide + H2O
benzoyl-Asn + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
best synthetic substrate
-
?
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-(tert-butyl)Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
recombinant protein
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
recombinant protein
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
inhibitory activity of phytocystatin variants of Hordeum vulgare tested against commercial human legumain
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
inhibitory activity of cystatin variants of Hordeum vulgare against endogenous legumain activity in protein extracts of Hordeum vulgare analyzed
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
inhibitory activity of cystatin variants of Hordeum vulgare against endogenous legumain activity in protein extracts of roots of Hordeum vulgare analyzed
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
activity of recombinant protein determined
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
effect of legumain on fibronectin degradation analyzed, role of legumain in control of extracellular matrix turnover determined
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
role of legumain in backbone cyclization of proteins determined, catalysis of protein backbone cyclization by coupling asparaginyl bond hydrolysis at the C terminus of the cyclotide domain with peptide bond ligation
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
role of legumain in backbone cyclization of proteins analyzed, catalysis of protein backbone cyclization by coupling asparaginyl bond hydrolysis at the C terminus of the cyclotide domain with peptide bond ligation
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
best synthetic substrate
-
?
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
role of legumain in backbone cyclization of proteins analyzed, catalysis of protein backbone cyclization by coupling asparaginyl bond hydrolysis at the C terminus of the cyclotide domain with peptide bond ligation
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
the canonical Asn P1 specificity is only observed at pH 6.0, whereas a decrease in pH to 5.0 or even 4.0 results in a substantially increased number of cleavages of which almost half are after Asp
-
-
?
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Gly-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Gly-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Gly-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Gly-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Gly-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Leu-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Leu-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Phe-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Pro-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Pro-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Pro-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Pro-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Pro-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Pro-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Tyr-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Tyr-Ala-Asn + 7-amino-4-methylcoumarin
-
low activity
-
?
benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
fluorogenic substrate
-
?
Boc-Asn-4-nitrophenyl ester + H2O
Boc-Asn + 4-nitrophenol
-
-
-
-
?
Boc-Asn-4-nitrophenyl ester + H2O
Boc-Asn + 4-nitrophenol
-
-
-
-
?
Bovine serum albumin + H2O
?
degradation in a dose-dependent manner at pH 7 and 30°C during 6 h of incubation, no cleavage detected at or above 37°C, strict specificity for hydrolysis of the peptide on the carboxyl side of the asparagines shown
-
-
?
Bovine serum albumin + H2O
?
degradation in a dose-dependent manner at pH 7 and 30°C during 6 h of incubation, no cleavage detected at or above 37°C, strict specificity for hydrolysis of the peptide on the carboxyl side of the asparagines shown
-
-
?
Bovine serum albumin + H2O
?
-
-
-
?
cathepsin B proform + H2O
activated cathepsin B
trans-processing and activation of the zymogen form of Schistosoma mansoni cathepsin B1 indicated
-
-
?
cathepsin B proform + H2O
activated cathepsin B
-
cleavage at the sequence Asp-Trp-Asn-Val-Ile-Pro, cleavage site between Asn and Val, between the prodomain and the mature regions of the protein, activation of the substrate, recombinant substrate from Schistosoma mansoni
-
?
cathepsin L + H2O
?
-
-
-
-
?
cathepsin L + H2O
?
-
processing/activation
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Cbz-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Cbz-Ala-Ala-azaAsn-7-amido-4-methyl-coumarin + H2O
?
-
-
-
-
?
Cbz-Ala-Ala-azaAsn-7-amido-4-methyl-coumarin + H2O
?
-
-
-
-
?
cystatin E + H2O
?
-
-
-
?
cystatin E + H2O
?
-
-
-
-
?
Dinitrophenyl-Pro-Glu-Ala-Asn-NH2 + H2O
Dinitrophenyl-Pro-Glu-Ala-Asn + NH4OH
-
-
-
-
?
Dinitrophenyl-Pro-Glu-Ala-Asn-NH2 + H2O
Dinitrophenyl-Pro-Glu-Ala-Asn + NH4OH
-
-
-
?
ETRNGVEE + H2O
ETRN + GVEE
-
-
-
-
?
ETRNGVEE + H2O
ETRN + GVEE
-
-
-
-
?
gelatinase + H2O
gelatinase fragment
-
62 kDa active form, cleavage site is Asn430
36 kDa active form
?
gelatinase + H2O
gelatinase fragment
-
62 kDa active form, cleavage site is Asn430
36 kDa active form
?
Hemoglobin + H2O
?
strict specificity for hydrolysis of the peptide on the carboxyl side of the asparagines indicated
-
-
?
Hemoglobin + H2O
?
strict specificity for hydrolysis of the peptide on the carboxyl side of the asparagines indicated
-
-
?
Hemoglobin + H2O
?
-
-
-
-
?
Hemoglobin + H2O
?
degradation of human hemoglobin to a major product of 4000 Dalton at pH 4.5, less efficiency at pH 6.0, yielding two products at 6000 and 4000 Dalton, no reaction at pH 7.0 observed, strict specificity for Asn at P1 shown
-
-
?
Hemoglobin + H2O
?
-
-
-
?
Hemoglobin + H2O
?
the enzyme is involved in host hemoglobin degradation
-
-
?
Hemoglobin + H2O
?
-
-
-
?
Hemoglobin + H2O
?
the enzyme is involved in host hemoglobin degradation
-
-
?
Hemoglobin + H2O
?
the recombinant beta-galactosidase fusion enzyme shows hemoglobinase activity
-
-
?
myelin basic protein + H2O
?
-
-
-
?
myelin basic protein + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
?
neurotensin + H2O
?
-
-
-
?
neurotensin + H2O
?
-
-
-
?
neurotensin + H2O
?
-
specific cleavage
-
-
?
papain-like cysteine proteinase precursors + H2O
activated papin-like cysteine proteinases
-
cleavage of C-terminal propeptide
-
?
papain-like cysteine proteinase precursors + H2O
activated papin-like cysteine proteinases
-
involved in the senescing of tissues and cell death
-
?
phaseolin + H2O
?
-
-
?
phaseolin + H2O
?
initiation of phaseolin proteolysis, enyme plays a key role in mobilization of phaseolin during and after kidney bean germination
-
?
precursor of basic vacuolar chitinase + H2O
active basic vacuolar chitinase
-
cleavage of C-terminal propeptide
-
?
precursor of basic vacuolar chitinase + H2O
active basic vacuolar chitinase
-
involved in the senescing of tissues and cell death
-
?
progelatinase A + H2O
gelatinase + ?
-
72 kDa proform, activation by cleavage of an asparaginyl peptide bonde to form the N-terminus of the mature active gelatinase
62 kDa mature form
?
progelatinase A + H2O
gelatinase + ?
-
72 kDa human proform, activation by cleavage of an asparaginyl peptide bonde to form the N-terminus of the mature active gelatinase
62 kDa mature form
?
progelatinase A + H2O
gelatinase A + gelatinase A propeptide
-
-
-
-
?
progelatinase A + H2O
gelatinase A + gelatinase A propeptide
-
activation
-
-
?
prolegumain + H2O
?
-
-
-
?
prolegumain + H2O
?
-
-
-
-
?
protein + H2O
peptides
-
involved in mobilization of storage proteins and stress response processes
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
?
protein + H2O
peptides
-
-
?
protein + H2O
peptides
-
enzyme is involved in antigen presentation within class II MHC positive cells and in pro-protein processing
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
?
protein + H2O
peptides
-
substrate specificity is dominated by the interaction of the S1 subsite
-
?
protein + H2O
peptides
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
-
-
?
protein + H2O
peptides
-
an Asn residue at P1 position is strictly required
-
?
protein + H2O
peptides
-
strong specificity for asparaginyl residues located at the protein surface
-
?
protein + H2O
peptides
-
enzyme is critically involved in the lysosomal processing of bacterial antigens for MHC class II presentation
-
?
protein + H2O
peptides
-
enzyme is involved mainly in storage protein breakdown
-
?
SESENGLEET + H2O
SESEN + GLEET
-
-
-
-
?
SESENGLEET + H2O
SESEN + GLEET
-
-
-
-
?
tert-butoxycarbonyl-Asn nitrophenyl ester + H2O
tert-butoxycarbonyl-Asn + 4-nitrophenol
-
-
-
-
?
tert-butoxycarbonyl-Asn nitrophenyl ester + H2O
tert-butoxycarbonyl-Asn + 4-nitrophenol
-
-
-
?
vitamin D-binding protein + H2O
?
cleavage sites are, besides others, N150-Y151, and N83-S84
-
?
vitamin D-binding protein + H2O
?
enzyme is involved in the processing of mcromolecules absorbed by proximal tubule cells
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
-
during germination and seedling growth legumains might also act as processing enzymes, protein processing and degradation by legumains, overview
-
?
additional information
?
-
the enzyme has protease activity and efficient peptide bond ligase activity
-
-
?
additional information
?
-
-
the enzyme has protease activity and efficient peptide bond ligase activity
-
-
?
additional information
?
-
substrate specificity, no activity with acetyl-Asp-Glu-Val-Asp-4-methylcoumarin-7-amide, and acetyl-Tyr-Val-Ala-Asp-4-methylcoumarin-7-amide
-
?
additional information
?
-
-
substrate specificity, no activity with acetyl-Asp-Glu-Val-Asp-4-methylcoumarin-7-amide, and acetyl-Tyr-Val-Ala-Asp-4-methylcoumarin-7-amide
-
?
additional information
?
-
enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues
-
-
?
additional information
?
-
-
enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues
-
-
?
additional information
?
-
the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A
-
-
?
additional information
?
-
-
the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A
-
-
?
additional information
?
-
-
almost all the peptide bonds on the carboxyl side of Asn residues are susceptible to the enzyme. The exceptions are cases where the residue is at the NH2 terminus or the second position from the NH2 terminus of the substrates and where it is N-glycosylated Asn
-
-
?
additional information
?
-
-
specificity overview with various peptide substrates, strict specificity towards asparagine bonds
-
-
?
additional information
?
-
-
thought to be involved in the hydrolysis of stored seed proteins
-
-
?
additional information
?
-
-
during germination and seedling growth legumains might also act as processing enzymes, protein processing and degradation by legumains, overview
-
?
additional information
?
-
-
the enzyme hydrolyzes peptide bonds with Asn in P1 and all 20 amino acids in P1' including S-alkylated Cys, with a few exceptions
-
-
?
additional information
?
-
enzyme is involved in host blood-meal digestion
-
-
?
additional information
?
-
-
enzyme is involved in host blood-meal digestion
-
-
?
additional information
?
-
-
recombinant HlLgm and HlLgm2 efficiently digest blood proteins, haemoglobin and bovine serum albumin
-
-
?
additional information
?
-
-
role of legumain in blood feeding and blood-meal digestion in ticks
-
-
?
additional information
?
-
-
no activity with acetyl-Phe-Tyr-Asn-4-methylcoumarin-7-amide
-
?
additional information
?
-
-
no activity with benzyloxycarbonyl-Gly-Ala-Gln-4-methylcoumarin-7-amide
-
?
additional information
?
-
-
no activity with pro-/gelatinase B
-
?
additional information
?
-
enzyme inhibits osteoclast-like multinucleated cell formation in humans by more than 60% and bone resorption in the fetal rat long bone
-
?
additional information
?
-
-
enzyme inhibits osteoclast-like multinucleated cell formation in humans by more than 60% and bone resorption in the fetal rat long bone
-
?
additional information
?
-
-
silencing of endogenous specific inhibitor cystatin M by siRNA leads to increased enzyme activity in MDA-686Ln cells and increasec cell migration/proliferation, and also to reduced cysteine protease inhibitor activity, overview
-
-
?
additional information
?
-
-
the enzyme controls antigen processing performing the key step, mechanism, the enzyme expression is reduced in endotoxin-tolerant monocytes and by lipopolysaccharide priming
-
-
?
additional information
?
-
-
the inhibition of osteoclast formation and bone resorption is a nonenzymatic function of prolegumain
-
-
?
additional information
?
-
involved in lysosomal processing of bacterial antigens for MHC class II presentation
-
-
?
additional information
?
-
-
involved in lysosomal processing of bacterial antigens for MHC class II presentation
-
-
?
additional information
?
-
subsite specificity of legumain analyzed to design fluorescent activity-based probes for monitoring endogenous legumain activity
-
-
?
additional information
?
-
-
subsite specificity of legumain analyzed to design fluorescent activity-based probes for monitoring endogenous legumain activity
-
-
?
additional information
?
-
-
enzyme promote cell migration and is associated with enhanced tissue invasion and metastases
-
-
?
additional information
?
-
-
legumain is a member of the C13 family of peptidases that specifically cleaves asparaginyl bonds
-
-
?
additional information
?
-
a gel based label-free proteomic approach (DIPPS-direct in-gel profiling of protease specificity) is developed that enables quick and reliable determination of protease cleavage specificities under large variety of experimental conditions. The methodology is based on in-gel digestion of the gel-separated proteome with the studied protease, enrichment of cleaved peptides by gel extraction, and subsequent mass spectrometry analysis combined with a length-limited unspecific database search. Specificity profiling of legumain at pH 4.0 reveales a pH-dependent change in the specificity of this protease. The canonical Asn P1 specificity is only observed at pH 6.0, whereas a decrease in pH to 5.0 or even 4.0 results in a substantially increased number of cleavages of which almost half are after Asp
-
-
?
additional information
?
-
ideal cleavage sequence: Pro-Thr-Asn (P3-P2-P1)
-
-
?
additional information
?
-
-
ideal cleavage sequence: Pro-Thr-Asn (P3-P2-P1)
-
-
?
additional information
?
-
the cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid. Legumain additionally exhibits ligase activity that prevails at pH above 5.5. Ligation is not the exact reverse of the proteolysis but can proceed via two distinct routes. Whereas the transpeptidation route involves aminolysis of the thioester, at pH 6 a cysteine-independent, histidine-assisted ligation route is detected
-
-
?
additional information
?
-
-
the cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid. Legumain additionally exhibits ligase activity that prevails at pH above 5.5. Ligation is not the exact reverse of the proteolysis but can proceed via two distinct routes. Whereas the transpeptidation route involves aminolysis of the thioester, at pH 6 a cysteine-independent, histidine-assisted ligation route is detected
-
-
?
additional information
?
-
-
contrasting its endopeptidase activity, legumain can develop a carboxypeptidase activity which remains stable at neutral pH
-
-
?
additional information
?
-
-
the enzyme is not required for class II MHC antigen presentation but is essential for processing of cathepsin L in mice
-
-
?
additional information
?
-
role in extracellular matrix remodeling via degradation of fibronectin indicated
-
-
?
additional information
?
-
-
role in extracellular matrix remodeling via degradation of fibronectin indicated
-
-
?
additional information
?
-
-
asparaginyl endopeptidase plays a pivotal role in the endosome and lysosomal degradation system and is implicated in antigen processing and presentation
-
-
?
additional information
?
-
-
asparaginyl endopeptidaseprotein substrates on the C-terminal side of asparagine
-
-
?
additional information
?
-
-
role in backbone cyclization of proteins determined, catalyis of peptide bond cleavage and of ligation of plant-specific cyclotides in a single processing event
-
-
?
additional information
?
-
during germination and seedling growth legumains might also act as processing enzymes, protein processing and degradation by legumains, overview
-
?
additional information
?
-
-
role in backbone cyclization of proteins determined, catalyis of peptide bond cleavage and of ligation of plant-specific cyclotides in a single processing event
-
-
?
additional information
?
-
asparaginyl endopeptidases are cysteine proteases that hydrolyze peptides and proteins on the carboxyl side of asparagine residues
-
-
?
additional information
?
-
-
asparaginyl endopeptidases are cysteine proteases that hydrolyze peptides and proteins on the carboxyl side of asparagine residues
-
-
?
additional information
?
-
-
enzyme has high YVADase (caspase-1-like) activity (set to 100%). It also exhibits a significant level of IETDase (caspase-8) activity (39%) and DEVDase activity (18%). Unprocessed VPE1 has residual VEIDase (caspase-6) and LEVDase (caspase-4) activities, and negligible LEHDase (caspase-9) and GRRase (metacaspase) activities
-
-
?
additional information
?
-
-
PrVPE1 binds to the DEVD tetrapeptide, a signature substrate for caspase-3
-
-
?
additional information
?
-
-
substrate specificity for P3 position residues
-
?
additional information
?
-
-
the enzyme hydrolyzes peptide bonds with Asn in P1
-
-
?
additional information
?
-
-
processing enzyme of vacuoles, is responsible for the conversion of several vacuolar precursors into their mature forms
-
-
?
additional information
?
-
-
during germination and seedling growth legumains might also act as processing enzymes, protein processing and degradation by legumains, overview
-
?
additional information
?
-
-
the enzyme is involved in degradation of seed storage proteins
-
-
?
additional information
?
-
bioinformatic approach, studies on vacuolar targeting by determination of minimal vacuole targeting motifs, GFP reporter analysis and subcellular staining indicated
-
-
?
additional information
?
-
bioinformatic approach, studies on vacuolar targeting, determination of minimal vacuole targeting motifs, GFP reporter analysis and subcellular staining indicated
-
-
?
additional information
?
-
-
no activity with acetyl-Phe-Tyr-Asn-4-methylcoumarin-7-amide
-
?
additional information
?
-
the enzyme strictly requires Asn at P1, and prefers Ala, Thr, Val, Asn in descending order at P2, and Thr, Ala, Val, and Ile at P3, overview
-
-
?
additional information
?
-
the enzyme strictly requires Asn at P1, and prefers Ala, Thr, Val, Asn in descending order at P2, and Thr, Ala, Val, and Ile at P3, overview
-
-
?
additional information
?
-
no pivotal role for cathepsin B1 activation in vivo
-
-
?
additional information
?
-
-
no pivotal role for cathepsin B1 activation in vivo
-
-
?
additional information
?
-
analysis of in vivo processing activity of schistosome legumain to convert cathepsin B1 into its active form, no essential role for cathepsin B1 activation in vivo determined
-
-
?
additional information
?
-
-
analysis of in vivo processing activity of schistosome legumain to convert cathepsin B1 into its active form, no essential role for cathepsin B1 activation in vivo determined
-
-
?
additional information
?
-
ideal cleavage sequence: Thr-Ala-Asn (P3-P2-P1)
-
-
?
additional information
?
-
-
no activity with angiotensin I, [Asn1,Val5]angiotensin II, peptides ASTTNYT and GSNKGAIIGLM, substance P, and dynorphin A fragment 1-13, no activity with Asn-4-methylcoumarin-7-amide or Asp-4-methylcoumarin-7-amide
-
?
additional information
?
-
-
no activity with pro-/gelatinase B
-
?
additional information
?
-
-
substrate specificity for P3 position residues
-
?
additional information
?
-
-
substrate specificity, overview, activity with oligopeptides derived from several protein substrates, overview, no activity with peptides AWYFNHLKDA, and ANDPNRDILA, no activity with substrate analogues containing mono-or di-N-methylasparagines, L-2-amino-3-ureidopropionic acid or citrulline in the P1 position
-
?
additional information
?
-
-
the enzyme acts strictly as asparaginyl endopeptidase, substrate specificity, overview
-
-
?
additional information
?
-
-
plant legumain shows a preference for bulky residues at P3 position
-
-
?
additional information
?
-
-
during germination and seedling growth legumains might also act as processing enzymes, protein processing and degradation by legumains, overview
-
?
additional information
?
-
-
role in backbone cyclization of proteins determined, catalyis of peptide bond cleavage and of ligation of plant-specific cyclotides in a single processing event
-
-
?
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(1-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
-
-
(1-[[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
-
-
(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidine-1-carboxylic acid
-
-
(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidine-1-carboxylic acid
-
-
(2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2-[[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl](methanesulfonyl)amino]butanamide
-
(3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbamic acid
-
-
(3S)-3-[(1-acetyl-L-prolyl)amino]-5-[(2,6-dimethylbenzoyl)oxy]-4-oxopentanoic acid
-
starting structure for development of activity-based probes for in vivo imaging
(4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]benzyl)carbamic acid
-
-
2,2-dimethyl-propionic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester
-
weak inhibition
2,6-dimethyl-benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester
-
enters cells and causes complete, irreversible inhibition of the enzyme, inhibition of autocatalytic processing in vivo
2-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]piperidine-1-carboxylic acid
-
-
3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxylic acid
-
-
4-(2-aminoethyl) benzenesulfonyl fluoride
AEBSF, 45.8% inhibition at 5 mM
4-chloromercuribenzoate
-
-
4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-1,3-thiazolidine-3-carboxylic acid
-
-
Ac-Tyr-Val-Ala-Asp-chloromethylketone
the rate of inhibition by Asp-CMK is approximately 3times more rapid at pH 4.0 than at pH 5.5
acetyl-Glu-Ser-Glu-Asn-aldehyde
Acetyl-Tyr-Val-Ala-Asp-aldehyde
Ala-Ala-Asn-chloromethylketone
the rate of inhibition by Asn-CMK is approximately 1.3times more rapid at pH 5.5 than at pH 4.0
alpha-2-Macroglobulin
proteinase inhibitor, may be a candidate for the binding of legumain as it is an agent for the removal of endopeptidases from extracellular fluids
-
antipain
papain-like cysteine proteinase inhibitor, 28.77% inhibition at 0.1 mM concentration relative to control
asparaginyl endopeptidase inhibitor
-
i.e. AEPi or cysteine protease inhibitor
-
benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester
-
-
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-benzyloxymethylketone
-
moderate inhibition
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromoacetate
-
-
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromomethylketone
-
strong specific and irreversible inhibition
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloroacetate
-
-
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloromethylketone
Benzyloxycarbonyl-Phe-Ala-CHN2
-
-
Boc-azaAsn-CH=CH-COOEt
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
carbobenzyloxy-Ala-Ala-(aza-Asn)-epoxycarboxylate ethyl ester
caspase 1 inhibitor V
-
-
-
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
CBZ-Ala-Phe-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
CBZ-Ala-Phe-azaAsn-CH=CH-CONHCH2-furyl
-
-
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
cystatin 3
strong inhibition
-
cystatin E
high affinity inhibitor of legumain
-
diisopropyl fluorophosphate
E-64
papain-like cysteine proteinase inhibitor, 7.51% inhibition at 0.3 mM concentration relative to control
egg white cystatin
concentration of 2 microM, 45.13% inhibition of recombinant protein activity
-
ethyl (2E)-4-[1-(2-amino-2-oxoethyl)-2-[[(2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[(2E)-2-(acetylamino)but-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)-3-(4-hydroxy-3-nitrophenyl)propanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-2-methylpropanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-3-methylbut-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[3-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-([(2S)-1-[4-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-[[(2S)-1-[[(2R)-1-acetylpiperidin-2-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-[[(2S)-1-[[(3S)-2-acetyl-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-[[(2S)-1-[[(4S)-3-acetyl-1,3-thiazolidin-4-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2E)-4-[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
-
-
ethyl (2S,3S)-3-[[1-(2-amino-2-oxoethyl)-2-[([2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]carbonyl]oxirane-2-carboxylate
-
-
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
-
-
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
-
-
ethyl (2S,3S)-3-[[2-[[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
-
starting structure for development of activity-based probes for in vivo imaging
ethyl (2S,3S)-3-[[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
-
-
FaCPI-1
-
strawberry cystatin, phytocystatin of Fragaria sp.
-
High molecular weight kininogen
-
-
-
High-molecular mass kininogen
kinin-free, F1.2-free
-
human cystatin C mutant L9G
-
inhibitory potential similar to wild-type cystatin C
-
human cystatin C mutant N39K
-
reduced inhibitory effect compared to the wild-type cystatin C
-
human cystatin C mutant R8G
-
inhibitory potential similar to wild-type cystatin C
-
human cystatin C mutant V10G
-
inhibitory potential similar to wild-type cystatin C
-
human cystatin C mutant W106G
-
inhibitory potential similar to wild-type cystatin C
-
human cystatin E/M
-
type 2 cystatin
-
human cystatin F
-
type 2 cystatin
-
HvCPI-4
-
cystatin HvCPI-4 of Hordeum vulgare
-
HvCPI-4-deltaT143-Cterm
-
C-terminal extended part of cystatin HvCPI-4
-
HvCPI-4-deltaT151-Cterm
-
C-terminal extended part of cystatin HvCPI-4
-
HvCPI-4-Q86P
-
cystatin HvCPI-4 of Hordeum vulgare, mutant Q86P
-
iodoacetic acid
0.1 mM, 82.4% remaining activity
L-3-carboxy-2,3-trans-epoxypropionyl-leucyl-amido(4-guanidino)butane
low molecular mass kininogen
-
-
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Mu-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2CH2Ph
-
-
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
0.1 mM, 0.23% remaining activity
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2,4-dichlorobenzene-1-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-difluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-cyano[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-ethyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methoxy[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-tert-butyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-bromobenzene-1-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-chlorobenzene-1-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-fluorobenzene-1-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-([1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[2'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(propan-2-yl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-[(propan-2-yl)oxy][1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(2H-1,3-benzodioxol-5-yl)benzene-1-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(trifluoromethyl)benzene-1-sulfonyl]-L-prolinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[2'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(1-methyl-1H-indazol-5-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(1-methyl-1H-indazol-7-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(2-methyl-2H-indazol-5-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(2-methyl-2H-indazol-7-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(4-methylpyridin-3-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(5-methylpyridin-3-yl)benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-[4-(trifluoromethyl)pyridin-3-yl]benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-[5-(trifluoromethyl)pyridin-3-yl]benzene-1-sulfonyl]propanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(2',3'-difluoro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(2',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(2',4'-difluoro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(3',5'-difluoro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(4'-butyl[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(4'-fluoro[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-(4'-tert-butyl[1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-([1,1'-biphenyl]-4-sulfonyl)-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(1,3-benzothiazol-5-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(4-chloropyridin-3-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(4-fluoropyridin-3-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(4-tert-butylpyridin-3-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(5-chloropyridin-3-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-3-[4-(5-fluoropyridin-3-yl)benzene-1-sulfonyl]-2,2-dimethylpropanamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(ethanesulfonyl)-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(ethanesulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(propane-1-sulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',5'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-chloro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-ethoxy[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
-
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
N-[(benzyloxy)carbonyl]-L-alanyl-N-[(1S,3E)-1-(2-amino-2-oxoethyl)-5-[methyl(naphthalen-1-yl)amino]-2,5-dioxopent-3-en-1-yl]-L-alaninamide
i.e. aza-peptide Michael acceptor Aza-Asn-11a, inhibition of trans-processing and activation of the zymogen form of Schistosoma mansoni cathepsin B1 by prior incubation with the legumain-specific inhibitor Aza-Asn-11a, reaction in CPS buffer, pH 5.5 for 30 min
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
p-chloromercuribenzene sulfonic acid
-
-
p-chloromercuribenzene-sulfonic acid
-
p-chloromercuribenzoate
-
-
pepstatin
concentration of 500 microM, 7.8% inhibition of recombinant protein activity
phenylmethanesulfonyl fluoride
phenylmethylsulfonyl fluoride
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
PMSF
serine peptidase inhibitor, 13.84% inhibition at 5 mM concentration relative to control
rat alpha1-macroglobulin
-
-
-
trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane
trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane
E-64, concentration of 500 microM, 8.88% inhibition of recombinant protein activity
Z-Phe-Ala-CHN2
i.e. benzyloxycarbonyl-phenylalanyl-alanyl-diazomethane, 40.8% inhibition at 0.01 mM
[(2S)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-[4-hydroxy-3-[hydroxy(oxo)ammonio]phenyl]-1-oxopropan-2-yl]carbamate
-
-
[(2Z)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobut-2-en-2-yl]carbamic acid
-
-
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
-
-
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxopent-4-yn-2-yl]carbamic acid
-
-
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-2-methyl-1-oxopropan-2-yl]carbamic acid
-
-
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobut-2-en-2-yl]carbamic acid
-
-
[1-[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
-
-
1,10-phenanthroline
concentration of 1 mM, 10 min before addition of substrate, 40% inhibition; concentration of 1mM, 10 min before addition of substrate, 40% inhibition observed
1,10-phenanthroline
27.5% inhibition at 5 mM
acetyl-Glu-Ser-Glu-Asn-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner
acetyl-Glu-Ser-Glu-Asn-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner
acetyl-Glu-Ser-Glu-Asn-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner
Acetyl-Tyr-Val-Ala-Asp-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner, reduced amounts of cyclic cyclotide produced in transiently transformed tobacco leaves determined
Acetyl-Tyr-Val-Ala-Asp-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner
Acetyl-Tyr-Val-Ala-Asp-aldehyde
-
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloromethylketone
Z-Ala-Ala-AzaAsn-CMK, 1 microM, 10 min before addition of substrate, 100% inhibition; Z-Ala-Ala-AzaAsn-CMK, 1 microM, 10 min before addition of substrate, 100% inhibition observed
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloromethylketone
-
strong specific and irreversible inhibition
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
carbobenzyloxy-Ala-Ala-(aza-Asn)-epoxycarboxylate ethyl ester
-
carbobenzyloxy-Ala-Ala-(aza-Asn)-epoxycarboxylate ethyl ester
-
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
-
-
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
-
-
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
-
-
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
-
-
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
-
-
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
-
-
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
-
-
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
-
-
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
-
-
Cu2+
strong inhibition
cystatin
-
from egg-white
-
cystatin
0.1 mM, 90.5% remaining activity
-
cystatin
from egg white, 62.3% inhibition at 0.003 mM concentration relative to control
-
cystatin
-
from chicken egg white
-
cystatin C
-
-
cystatin C
-
endogenous inhibitor
-
cystatin E/M
-
-
-
cystatin E/M
-
cystatin E/M controls both intra- and extracellular legumain activity
-
cystatin M
high affinity inhibitor of legumain
-
cystatin M
-
specific endogenous inhibitor of lysosomal cysteine proteases, diverse tissue distribution, target specificity, and biological function, overview, high expression level in MDA-686Ln cells, silencing of cystatin M by siRNA leads to increased enzyme activity in MDA-686Ln cells
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
not
E64
17.1% inhibition at 0.001 mM
E64
slight inhibition at 1 mM
Hg2+
strong inhibition
Human cystatin C
-
-
-
Human cystatin C
-
competitive inhibition
-
iodoacetamide
-
-
iodoacetamide
concentration of 5 mM,10 min before addition of substrate, 100% inhibition; concentration of 5 mM, 10 min before addition of substrate, 100% inhibition determined
iodoacetamide
concentration of 3 mM, 100% inhibition of recombinant protein activity, BSA cleavage inhibited by 5 mM iodoacetamide
iodoacetamide
100% inhibition at 3 mM concentration relative to control
iodoacetamide
complete inhibition at 5 mM inhibitor concentration
iodoacetamide
11.6% remaining activity
iodoacetamide
irreversible millimolar inhibitor
iodoacetate
-
-
iodoacetate
55.8 remaining activity
L-3-carboxy-2,3-trans-epoxypropionyl-leucyl-amido(4-guanidino)butane
-
-
L-3-carboxy-2,3-trans-epoxypropionyl-leucyl-amido(4-guanidino)butane
-
i.e. E-64, not
leupeptin
-
-
leupeptin
concentration of 300 microM, 16.07% inhibition of recombinant protein activity
leupeptin
papain-like cysteine proteinase inhibitor, 3.9% inhibition at 0.3 mM concentration relative to control
leupeptin
47.3% inhibition at 1 mM
leupeptin
slight inhibition at 1 mM
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
-
-
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
-
-
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
N-ethylmaleimide
-
N-ethylmaleimide
concentration of 3 mM, 95.74% inhibition of recombinant protein activity
N-ethylmaleimide
100% inhibition at 3 mM concentration relative to control
N-ethylmaleimide
complete inhibition at 2 mM
N-ethylmaleimide
16.6% remaining activity
N-Phenylmaleimide
-
-
N-Phenylmaleimide
-
strong inhibition
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
-
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
-
-
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
-
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
-
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
-
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
-
NEM
-
-
ovocystatin
-
weak inhibition, from egg-white
-
ovocystatin
-
from egg-white
-
ovocystatin
-
from chicken egg white
-
PCMB
-
-
pepstatin A
0.01 mM, 86.9% remaining activity
pepstatin A
aspartic peptidase inhibitor has minimal effects on the enzyme activity, 12.22% inhibition at 0.3 mM concentration relative to control
pepstatin A
8.4% inhibition at 0.1 mM
pepstatin A
-
no effect on ability to cleave the Asn-containing substrate
pepstatin A
-
no effect on ability to cleave the Asn-containing substrate
pepstatin A
-
no effect on ability to cleave the Asn-containing substrate
phenylmethanesulfonyl fluoride
PMSF, concentration of 2 mM, 10 min before addition of substrate, 66% inhibition; PMSF, concentration of 2 mM, 10 min before addition of substrate, 66% inhibition shown
phenylmethanesulfonyl fluoride
PMSF, concentration of 5 mM, 19% inhibition of recombinant protein activity
phenylmethylsulfonyl fluoride
-
no effect on ability to cleave the Asn-containing substrate
phenylmethylsulfonyl fluoride
-
no effect on ability to cleave the Asn-containing substrate
phenylmethylsulfonyl fluoride
-
no effect on ability to cleave the Asn-containing substrate
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
-
-
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
-
-
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
-
-
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
-
-
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
-
-
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
-
-
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
-
-
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
-
-
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
-
-
trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane
-
i.e. E-64, no effect on ability to cleave the Asn-containing substrate
trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane
-
i.e. E-64, no effect on ability to cleave the Asn-containing substrate
trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane
-
i.e. E-64, no effect on abilityto cleave the Asn-containing substrate
additional information
no inhibition by E-64, leupeptin, and elastatinal
-
additional information
-
no inhibition by E-64, leupeptin, and elastatinal
-
additional information
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
no inhibition by E64
-
additional information
no inhibition by the general cysteine protease inhibitor E-64
-
additional information
-
no inhibition by the general cysteine protease inhibitor E-64
-
additional information
no significant inhibition by trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM; no significant inhibition observed by using trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM
-
additional information
no significant inhibition by trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM; no significant inhibition observed by using trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM
-
additional information
-
no significant inhibition by trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM; no significant inhibition observed by using trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) in a concentration of 10 microM, leupeptin in a concentration of 10 microM or pepstatin in a concentration of 5 microM
-
additional information
-
alpha2-macroglobulin; leupeptin; not: EDTA; pepstatin
-
additional information
-
no inhibition by E-64 and leupeptin
-
additional information
-
the enzyme expression is reduced by lipopolysaccharide priming and in endotoxin-tolerant monocytes
-
additional information
inhibitory activity of the phytocystatins HvCPI-4 of Hordeum vulgare and FaCPI-1 of Fragaria sp. measured by the inhibition of legumain proteinase activity, ability of HvCPI-4 and FaCPI-1 to inhibit human legumain in vitro demonstrated
-
additional information
-
inhibitory activity of the phytocystatins HvCPI-4 of Hordeum vulgare and FaCPI-1 of Fragaria sp. measured by the inhibition of legumain proteinase activity, ability of HvCPI-4 and FaCPI-1 to inhibit human legumain in vitro demonstrated
-
additional information
inhibitor specificity profiles of cathepsin B and legumain regarded and used for analysis of the suitability of fluorescent activity-based probes
-
additional information
-
inhibitor specificity profiles of cathepsin B and legumain regarded and used for analysis of the suitability of fluorescent activity-based probes
-
additional information
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
inhibitory activity measured by the inhibition of legumain proteinase activity, phytocystatins that are able to inhibit human legumain also inhibit the barley legumain proteinase activities in developing roots, endogenous barley legumain activities inhibited by iodoacetamide, no inhibition by the non-legumain inhibitors leupeptin and E64 observed; inhibitory effects against endogenous legumain activity in barley protein extracts tested, inhibitory activity measured by the inhibition of legumain-like proteinase activity, phytocystatins able to inhibit human legumain also inhibit the barley legumain proteinase activities in developing endosperms, endogenous barley legumain activities inhibited by iodoacetamide, no inhibition by the non-legumain inhibitors leupeptin and E64 observed
-
additional information
-
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
no inhibition by leupeptin
-
additional information
-
not: EDTA; phenylmethylsulfonyl fluoride
-
additional information
no inhibition with EDTA, PMSF, pepstatin A, leupeptin, and E-64
-
additional information
-
no inhibition with EDTA, PMSF, pepstatin A, leupeptin, and E-64
-
additional information
E-64 has no effect on enzyme activity
-
additional information
no inhibition by Z-Phe-Ala-CHN2 and 1,10-phenanthroline
-
additional information
no inhibition by Z-Phe-Ala-CHN2 and 1,10-phenanthroline
-
additional information
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
glycosylation of asparaginyl residues totally prevents cleavage by the enzyme, no binding to human alpha2-macroglobulin
-
additional information
-
no inhibition by PMSF, EDTA and 1,10-phenanthroline
-
additional information
-
construction and irreversible specific inhibition of the enzyme by several derivatives of Michael acceptor inhibitors based on the backbone benzyloxycarbonal-L-Ala-L-Ala-L-Asn, overview
-
additional information
-
no inhibition by E-64 and EDTA
-
additional information
-
no inhibition by E-64, i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanidino)-butane, no inhibition by PMSF, pepstatin and 1,10-phenanthroline
-
additional information
-
inhibition mechanism by human cystatins, enzyme inhibitor complex formation analysis, no inhibition by human type 1 cystatins A and B, type 2 cystatin D, and type 3 low MW kininogen
-
additional information
-
no inhibition by E64 and leupeptin
-
additional information
-
the enzyme is not inhibited by the broad spectrum cysteine protease inhibitors E-64, PMSF nor by the aspartate protease inhibitor pepstatin A
-
additional information
-
-
-
additional information
-
not: EDTA; N-tosyl-L-lysine chloromethyl ketone; phenylmethylsulfonyl fluoride
-
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0.0000093
(1-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000044 - 0.0000086
(1-[[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
0.0000083
(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000093
(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.005854
(2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2-[[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl](methanesulfonyl)amino]butanamide
Homo sapiens
pH 7.4, 37°C
0.001
(3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000704
(3S)-3-[(1-acetyl-L-prolyl)amino]-5-[(2,6-dimethylbenzoyl)oxy]-4-oxopentanoic acid
Mus musculus
-
pH 7.4
0.000267
(4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]benzyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000638
2-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]piperidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.001
3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000167
4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-1,3-thiazolidine-3-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.00075
Boc-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00003 - 0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.000005 - 0.000068
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00002 - 0.000058
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.0000075 - 0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
0.0000085 - 0.00008
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00008 - 0.00027
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.0000045 - 0.000031
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00000052 - 0.00028
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
0.0005
CBZ-Ala-Phe-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.0018
CBZ-Ala-Phe-azaAsn-CH=CH-CONHCH2-furyl
Ixodes ricinus
-
pH 6.8, 25°C
0.000013 - 0.0005
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
0.00035 - 0.00105
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
0.000065 - 0.0001
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
0.00000037 - 0.00005
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00000035 - 0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.00000014 - 0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00075 - 0.0008
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.00075 - 0.00085
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
0.0083
ethyl (2E)-4-[1-(2-amino-2-oxoethyl)-2-[[(2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000141
ethyl (2E)-4-[2-([(2S)-1-[(2E)-2-(acetylamino)but-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)-3-(4-hydroxy-3-nitrophenyl)propanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000065
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000017
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000198
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-2-methylpropanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000148
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-3-methylbut-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-([(2S)-1-[3-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000267
ethyl (2E)-4-[2-([(2S)-1-[4-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000638
ethyl (2E)-4-[2-[[(2S)-1-[[(2R)-1-acetylpiperidin-2-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-[[(2S)-1-[[(3S)-2-acetyl-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000167
ethyl (2E)-4-[2-[[(2S)-1-[[(4S)-3-acetyl-1,3-thiazolidin-4-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000093
ethyl (2E)-4-[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0093
ethyl (2S,3S)-3-[[1-(2-amino-2-oxoethyl)-2-[([2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0081
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0086
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000115
ethyl (2S,3S)-3-[[2-[[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
pH 7.4
0.0044
ethyl (2S,3S)-3-[[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.018 - 0.068
HvCPI-4-deltaT143-Cterm
-
0.022 - 0.091
HvCPI-4-deltaT151-Cterm
-
0.033 - 0.11
HvCPI-4-Q86P
-
0.000065 - 0.000103
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.0000033 - 0.000045
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00145
Mu-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2CH2Ph
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000023 - 0.000101
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
0.0000017 - 0.00009
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.000006 - 0.00006
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
0.0006 - 0.00075
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.000006
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000035
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000593
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2,4-dichlorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000169
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000023
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-difluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000033 - 0.000047
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
0.000045 - 0.000067
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
0.000033
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-cyano[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000071
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-ethyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000006
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methoxy[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000032
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000071
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-tert-butyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000282
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-bromobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000073
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-chlorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000269
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-fluorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000012
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-([1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000093
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[2'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(propan-2-yl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000121
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000073 - 0.000969
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-[(propan-2-yl)oxy][1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
0.000049
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(2H-1,3-benzodioxol-5-yl)benzene-1-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000332
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(trifluoromethyl)benzene-1-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.003889
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(ethanesulfonyl)-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.005854
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000378
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.00505
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000882
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000601
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001818
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001086
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(ethanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001459
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.007749
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
Homo sapiens
pH 7.4, 37°C
0.006745
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(propane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000356
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.006296
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000252
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001359 - 0.009249
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',5'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
0.000425
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-chloro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)alaninamide
Homo sapiens
pH 7.4, 37°C
0.000586
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-ethoxy[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.002272
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.002259
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000128
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.004384
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
Homo sapiens
pH 7.4, 37°C
0.000323 - 0.001035
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
0.008
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000045 - 0.0003
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
0.0005 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
0.000018 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
0.0075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000025 - 0.0002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
0.0000035 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
0.008 - 0.01
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000075 - 0.0008
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
0.00001 - 0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
0.0000055 - 0.000035
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
0.00005 - 0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
0.0000018 - 0.00006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
0.00001 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
0.00000055 - 0.000055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
0.0009 - 0.015
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
0.0000023 - 0.00045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
0.0001 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
0.002 - 0.0027
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
0.0000045 - 0.000031
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
0.00001 - 0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001 - 0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
0.00008 - 0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
0.00006 - 0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000006 - 0.000062
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000006 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000005 - 0.000038
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
0.0000028 - 0.00001
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
0.0000024 - 0.0001
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
0.000017 - 0.00008
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.000008 - 0.000057
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.0004 - 0.00075
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
0.000015 - 0.00008
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
0.000012 - 0.000072
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.0000085 - 0.00016
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
0.00003 - 0.00022
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
0.00015 - 0.0006
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.000031 - 0.00009
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.0000026 - 0.00007
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.0000038 - 0.00004
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.000013 - 0.00025
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
0.0000085 - 0.0003
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.000011 - 0.00015
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.001
[(2S)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-[4-hydroxy-3-[hydroxy(oxo)ammonio]phenyl]-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000141
[(2Z)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobut-2-en-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000065
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000017
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxopent-4-yn-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000198
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-2-methyl-1-oxopropan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000148
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobut-2-en-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000081
[1-[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
additional information
additional information
-
0.0000044
(1-[[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000086
(1-[[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.00003
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.000005
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.000068
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.00002
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.000058
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000075
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Ixodes ricinus
-
pH 6.8, 25°C
0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000085
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00008
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.00008
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.00027
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.0000045
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.000031
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000052
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00028
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.000013
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.000138
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.0005
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.00035
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.00105
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.000065
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.0001
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000037
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00005
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000035
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000014
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.00075
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.0008
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.00075
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.00085
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.02
FaCPI-1
Hordeum vulgare
-
endosperm
-
0.2
FaCPI-1
Hordeum vulgare
-
root extract
-
0.038
HvCPI-4
Hordeum vulgare
-
endosperm
-
0.12
HvCPI-4
Hordeum vulgare
-
root extract
-
0.018
HvCPI-4-deltaT143-Cterm
Hordeum vulgare
-
endosperm
-
0.068
HvCPI-4-deltaT143-Cterm
Hordeum vulgare
-
root extract
-
0.022
HvCPI-4-deltaT151-Cterm
Hordeum vulgare
-
endosperm
-
0.091
HvCPI-4-deltaT151-Cterm
Hordeum vulgare
-
root extract
-
0.033
HvCPI-4-Q86P
Hordeum vulgare
-
endosperm
-
0.11
HvCPI-4-Q86P
Hordeum vulgare
-
root extract
-
0.000065
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.000103
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000033
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.000045
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000023
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.000101
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000017
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00009
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.000006
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.00006
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.0006
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.00075
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.000033
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000047
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000045
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000067
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000073
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-[(propan-2-yl)oxy][1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000969
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-[(propan-2-yl)oxy][1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.001359
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',5'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.009249
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',5'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000323
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001035
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.0000045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0003
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000018
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000025
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000035
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000004
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00025
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0008
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000085
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000035
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000018
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00000055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0009
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.015
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000023
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000012
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00009
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0027
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000031
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00035
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00008
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0003
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000062
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000008
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000005
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000038
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000028
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000024
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.0001
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.000017
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00008
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.000008
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.000057
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.0004
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
Ixodes ricinus
-
pH 6.8, 25°C
0.00075
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
Schistosoma mansoni
-
pH 6.8, 25°C
0.000015
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00008
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.000012
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.000072
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000085
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.00016
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.00003
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00022
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.00015
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.0006
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Schistosoma mansoni
-
pH 6.8, 25°C
0.000031
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00009
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000026
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00007
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000038
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Ixodes ricinus
-
pH 6.8, 25°C
0.00004
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
Schistosoma mansoni
-
pH 6.8, 25°C
0.000013
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Ixodes ricinus
-
pH 6.8, 25°C
0.00025
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
Schistosoma mansoni
-
pH 6.8, 25°C
0.0000085
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.0003
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
Schistosoma mansoni
-
pH 6.8, 25°C
0.000011
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Ixodes ricinus
-
pH 6.8, 25°C
0.00015
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
Schistosoma mansoni
-
pH 6.8, 25°C
additional information
additional information
Ixodes ricinus
IC50 concentration of the aza-peptide Michael acceptor Aza-Asn-11a in a range of about 500 nM determined
-
additional information
additional information
Ixodes ricinus
-
IC50 concentration of the aza-peptide Michael acceptor Aza-Asn-11a in a range of about 500 nM determined
-
additional information
additional information
Hordeum vulgare
-
inhibitory doses for 50% proteinase activity inhibition higher for root legumain activity than for endosperm one
-
additional information
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Trichomonas vaginalis
IC50 is above 0.01 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Ixodes ricinus
-
IC50 is above 0.02 mM, 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E)-4-oxo-4-phenylbut-2-enoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Schistosoma mansoni
-
no inhibition after 20 min of preincubation with inhibitor in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Schistosoma mansoni
-
no inhibition after 20 min of preincubation with inhibitor in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
Schistosoma mansoni
-
IC50 is above 0.002 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
Schistosoma mansoni
-
IC50 is above 0.002 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
Ixodes ricinus
-
IC50 is above 0.15 mM, 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
Trichomonas vaginalis
IC50 is below 0.000001 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
IC50 is below 0.000001 mM, 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
no inhibition after 20 min of preincubation with inhibitor in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
Ixodes ricinus
-
IC50 is below 0.000001 mM, 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
Trichomonas vaginalis
IC50 is below 0.000001 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Trichomonas vaginalis
IC50 is below 0.000001 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
Trichomonas vaginalis
IC50 is below 0.000001 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
Ixodes ricinus
-
IC50 is below 0.000001 mM, 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
additional information
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
Trichomonas vaginalis
IC50 is below 0.00001 mM, in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
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Schistosoma mansoni (P09841), Schistosoma mansoni
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Homo sapiens
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Opisthorchis viverrini (Q208S4), Opisthorchis viverrini
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Bos taurus (Q95M12), Bos taurus
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Chan, C.B.; Abe, M.; Hashimoto, N.; Hao, C.; Williams, I.R.; Liu, X.; Nakao, S.; Yamamoto, A.; Li, S.Y.; Hara-Nishimura, I.; Asano, M.; Ye, K.
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Mus musculus
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Briggs, J.; Haugen, M.; Johansen, H.; Riker, A.; Abrahamson, M.; Fodstad, .; Mlandsmo, G.; Solberg, R.
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Homo sapiens (Q99538)
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Homo sapiens, Mus musculus
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Homo sapiens (Q99538), Homo sapiens
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Smith, R.; Johansen, H.T.; Nilsen, H.; Haugen, M.H.; Pettersen, S.J.; Maelandsmo, G.M.; Abrahamson, M.; Solberg, R.
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
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Homo sapiens
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Solberg, R.; Smith, R.; Almloef, M.; Tewolde, E.; Nilsen, H.; Johansen, H.T.
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Homo sapiens
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Phylogenetically distant barley legumains have a role in both seed and vegetative tissues
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Hordeum vulgare
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Pierre, O.; Hopkins, J.; Combier, M.; Baldacci, F.; Engler, G.; Brouquisse, R.; Herouart, D.; Boncompagni, E.
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Medicago truncatula
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Santos-Silva, L.K.; Soares-Costa, A.; Gerald, L.T.; Meneghin, S.P.; Henrique-Silva, F.
Recombinant expression and biochemical characterization of sugarcane legumain
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Saccharum sp. (H2EUL5)
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Christoff, A.P.; Turchetto-Zolet, A.C.; Margis, R.
Uncovering legumain genes in rice
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Oryza sativa
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Site-specific cleavage of acetoacetyl-CoA synthetase by legumain
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Mus musculus (O89017), Mus musculus
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Elsaesser, B.; Zauner, F.B.; Messner, J.; Soh, W.T.; Dall, E.; Brandstetter, H.
Distinct roles of catalytic cysteine and histidine in the protease and ligase mechanisms of human legumain as revealed by DFT-based QM/MM simulations
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Homo sapiens (Q99538), Homo sapiens
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Yamane, T.; Yamamoto, Y.; Nakano, Y.; Nakagaki, T.; Ohkubo, I.; Ariga, H.
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells
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Mus musculus (O89017), Mus musculus
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Structure and function of legumain in health and disease
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Mammalia, unidentified plant, Schistosoma mansoni (P09841), Bos taurus (Q95M12), Homo sapiens (Q99538), Homo sapiens
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Lunde, N.N.; Haugen, M.H.; Bodin Larsen, K.B.; Damgaard, I.; Pettersen, S.J.; Kasem, R.; Rut, W.; Drag, M.; Poreba, M.; Johansen, H.T.; Solberg, R.
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Bos taurus (Q95M12), Bos taurus
brenda
Ness, K.A.; Eddie, S.L.; Higgins, C.A.; Templeman, A.; DCosta, Z.; Gaddale, K.K.; Bouzzaoui, S.; Jordan, L.; Janssen, D.; Harrison, T.; Burkamp, F.; Young, A.; Burden, R.; Scott, C.J.; Mullan, P.B.; Williams, R.
Development of a potent and selective cell penetrant Legumain inhibitor
Bioorg. Med. Chem. Lett.
25
5642-5645
2015
Homo sapiens (Q99538)
brenda
Ness, K.A.; Eddie, S.L.; Burton, S.; Harrison, T.; Mullan, P.; Williams, R.
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors
Bioorg. Med. Chem. Lett.
26
413-416
2016
Homo sapiens (Q99538)
brenda
Eddie, S.L.; Gregson, A.; Graham, E.; Burton, S.; Harrison, T.; Burden, R.; Scott, C.J.; Mullan, P.B.; Williams, R.
Identification and SAR exploration of a novel series of legumain inhibitors
Bioorg. Med. Chem. Lett.
29
1546-1548
2019
Homo sapiens (Q99538)
brenda
Vidmar, R.; Vizovisek, M.; Turk, D.; Turk, B.; Fonovic, M.
Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain
EMBO J.
36
2455-2465
2017
Homo sapiens (Q99538)
brenda
Hartmann, D.; Sima, R.; Konvickova, J.; Perner, J.; Kopacek, P.; Sojka, D.
Multiple legumain isoenzymes in ticks
Int. J. Parasitol.
48
167-178
2018
Ixodes scapularis, Ixodes scapularis (A0A1S6XZC8)
brenda
Nourrisson, C.; Wawrzyniak, I.; Cian, A.; Livrelli, V.; Viscogliosi, E.; Delbac, F.; Poirier, P.
On Blastocystis secreted cysteine proteases a legumain-activated cathepsin B increases paracellular permeability of intestinal Caco-2 cell monolayers
Parasitology
143
1713-1722
2016
Blastocystis hominis (D8M176)
brenda
Holzhausen, J.; Haake, C.; Schicht, S.; Hinse, P.; Jordan, D.; Kremmer, E.; Strube, C.
Biological function of Dictyocaulus viviparus asparaginyl peptidase legumain-1 and its suitability as a vaccine target
Parasitology
145
378-392
2018
Dictyocaulus viviparus (I6R478), Dictyocaulus viviparus
brenda
Zauner, F.B.; Dall, E.; Regl, C.; Grassi, L.; Huber, C.G.; Cabrele, C.; Brandstetter, H.
Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation
Plant Cell
30
686-699
2018
Arabidopsis thaliana (Q39119), Arabidopsis thaliana
brenda
Santana, J.O.; Freire, L.; de Sousa, A.O.; Fontes Soares, V.L.; Gramacho, K.P.; Pirovani, C.P.
Characterization of the legumains encoded by the genome of Theobroma cacao L
Plant Physiol. Biochem.
98
162-170
2016
Theobroma cacao
brenda
Zhao, T.; Li, Z.; Guo, Z.; Wang, A.; Liu, Z.; Zhao, Q.; Li, Y.; McKenzie, E.A.; Diao, A.
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors
Protein Expr. Purif.
150
12-16
2018
Homo sapiens (Q99538), Homo sapiens
brenda