Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)-sphingosine + 1,2-dimyristoyl-sn-glycero-3-phosphocholine
N-(N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl)sphingosylphosphorylcholine + ?
-
-
-
-
?
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine + phosphatidylcholine
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
C17-ceramide + 1,2-dimyristoyl-rac-glycero-3-phosphocholine
C17-sphingomyelin + 1,2-dimyristoyl-rac-glycerol
-
-
-
?
ceramide + phosphatidylcholine
sphingomyelin + 1,2-diacyl-sn-glycerol
L-alpha-phosphatidylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide
?
-
i.e. NBD-C6-ceramide
-
-
?
L-alpha-phosphatidylcholine + NBD-C6-ceramide
?
i.e. N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide
-
-
?
N-(6-((7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine + a phosphatidylcholine
N-(6-((7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
i.e. C6-NBD-ceramide
i.e. C6-NBD-sphingomyelin or C6-NBDCerPCho
-
?
N-lauroyl-D-erythro-sphingosylphosphorylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide
?
-
i.e. lauroyl sphingomyelin and C6-NBD-ceramide
-
-
?
phosphatidylcholine + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
-
ir
phosphatidylcholine + C6-ceramide
?
-
-
-
-
?
phosphatidylcholine + C6-ceramide
C6-sphingomyelin + 1,2-diacyl-sn-glycerol
phosphatidylcholine + C6-NBD-ceramide
?
-
i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide
-
-
?
phosphatidylcholine + C8-ceramide
C7-sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
phosphatidylcholine + ceramide
sphingomyelin + diacylglycerol
sphingomyelin + diacylglycerol
ceramide + phosphatidylcholine
-
-
-
-
?
additional information
?
-
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
r
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
substrate C6-NBD-ceramide, molecular docking studies and interaction modes of phosphatidylcholine with the active site of SMS1, overview
detection and quantifcation of C6-NBD-sphingomyelin by HPLC using the reversed-phase C18 column and an isocratic elution with methanol/water/trifluoroacetic acid (89:11:0.1 (v/v))
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
?
ceramide + phosphatidylcholine
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
ceramide + phosphatidylcholine
sphingomyelin + 1,2-diacyl-sn-glycerol
-
the enzyme restores homeostasis between sphingomyelin and ceramide pools
-
-
?
ceramide + phosphatidylcholine
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + C6-ceramide
C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + C6-ceramide
C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
phosphatidylcholine + C6-ceramide
C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + diacylglycerol
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + diacylglycerol
SMS2 is crucial to cellular lipid metabolism
-
-
?
additional information
?
-
-
synthesis of N-6[7-nitro-2,1,3-benzoxadiazol-4-yl]aminohexanoyl-phosphatidylcholine on the basolateral cell surface of MDCK cells occurs via the reverse reaction of a sphingomyelin synthase
-
-
?
additional information
?
-
-
both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells, sphingomyelin synthesis plays a critical role in cell growth and survival, overview
-
-
?
additional information
?
-
-
membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview
-
-
?
additional information
?
-
-
SMS1 converts de novo ceramide into sphingomyelin, overview
-
-
?
additional information
?
-
-
SMS1 suppresses ceramide production and apoptosis post-photodamage
-
-
?
additional information
?
-
-
SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview
-
-
?
additional information
?
-
-
sphingomyelin plays a very important role both in cell membrane formation, inhibition of sphingomyelin synthase affects intracellular sphingomyelin accumulation and plasma membrane lipid organization, overview
-
-
?
additional information
?
-
sphingomyelin synthase sits at the crossroads of sphingomyelin, ceramide, and diacylglycerol metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce sphingomyelin and diacylglycerol, thereby regulating lipid messengers which play a role in cell survival and apoptosis
-
-
?
additional information
?
-
sphingomyelin synthase sits at the crossroads of sphingomyelin, ceramide, and diacylglycerol metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce sphingomyelin and diacylglycerol, thereby regulating lipid messengers which play a role in cell survival and apoptosis
-
-
?
additional information
?
-
-
sphingomyelin synthases regulate production of diacylglycerol at the Golgi apparatus. Downregulation or up-regulation of SMS1 or SMS2 reduces or enhances de novo synthesis of sphingomyelin, pathway regulation, overview
-
-
?
additional information
?
-
-
SMSr proteins display ceramide phosphoethanolamine synthase activity, SMSr produces only trace amounts of ceramide phosphoethanolamine, i.e., 300fold less than SMS1-derived sphingomyelin
-
-
?
additional information
?
-
-
sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
-
-
?
additional information
?
-
sphingomyelin measurement via a four-step enzymatic process involving sphingomyelinase and histochemic detection
-
-
?
additional information
?
-
-
sphingomyelin measurement via a four-step enzymatic process involving sphingomyelinase and histochemic detection
-
-
?
additional information
?
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression
-
-
?
additional information
?
-
-
SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview
-
-
?
additional information
?
-
development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of 6-((N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine (C6-NBD-Cer) and 6-((N-(7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine (C6-NBDCerPCho) in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, kinetics, overview
-
-
?
additional information
?
-
-
highly purified sphingomyelin synthase preparation also shows neutral sphingomyelinase activity
-
-
?
additional information
?
-
-
SMS2 may play a crucial role in the lipid metabolism in arosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids
-
-
?
additional information
?
-
SMS2 may play a crucial role in the lipid metabolism in arosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids
-
-
?
additional information
?
-
-
SMS1 is a key enzyme in the sphingomyelin cycle, metabolites of the cycle play an important role in neuronal death after ischemia, mechanism underlying cerebral ischemia, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
150fold selectivity for isoform SGMS2 over SGMS1; 150fold selectivity for isoform SGMS2 over SGMS1. The interaction with SGMS2 requires the presence of the amino acids S227 and H229, which are located in the catalytic domain of SMS2
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
selectivity ratio is more than 1400fold for purified isoform SGMS2 over SGMS1. The compound dose-dependently diminishes apoB secretion from Huh7 cells, and significantly reduces the SGMS activity and increases cholesterol efflux from macrophages. It inhibits the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. In C57BL/6J mice, the compound is orally efficacious.
2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(2-(trifluoromethoxy)phenyl)acetamide
-
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(o-tolyl)acetamide
-
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-phenylacetamide
-
2-(benzyloxy)-N-(pyridin-2-yl)benzamide
-
2-(benzyloxy)-N-(pyridin-3-yl)benzamide
-
2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine
-
2-[[2-((5-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)pentyl)oxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
compound shows dual activity against both phospholipase A2 and sphingomyelin synthase
2-[[2-((6-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)hexyl)oxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
-
2-[[2-(3-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)propoxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
-
2-[[2-(4-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)butoxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
-
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-(pyridin-4-yl)benzamide
-
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-phenethylbenzamide
-
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
lysenin
-
is a sphingomyelin-directed cytolysin purified from the earthworm, which specifically binds to membrane sphingomyelin and induces pore formation in the plasma membrane and subsequent cell death
-
Mn2+
-
4 mM, about 40% inhibition
N-(2-cyanophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(2-nitrophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-((2-phenylpyridin-4-yl)methoxy)-1,2-dihydroquinoline-3-carboxamide
880fold selectivity for isoform SGMS2 over SGMS1; 880fold selectivity for isoform SGMS2 over SGMS1
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(pyrrolidin-1-yl)-1,2-dihydroquinoline-3-carboxamide
more than 100fold selectivity for isoform SGMS2 over SGMS1; more than 100fold selectivity for isoform SGMS2 over SGMS1
N-(3-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(3-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-chlorobenzyl)-2-(4-(N-(3-phenylpropyl)sulfamoyl)phenoxy)acetamide
-
N-(4-chlorobenzyl)-2-(4-(N-(4-chlorobenzyl)sulfamoyl)phenoxy)acetamide
-
N-(4-chlorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-chlorobenzyl)-2-(4-(N-phenylsulfamoyl)phenoxy)acetamide
-
N-(4-chlorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-fluoro-2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-fluorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-methoxybenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(4-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide
-
N-benzyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-phenethyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
-
N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide
-
Ni2+
-
2 mM, 75% inhibition
potassium tricyclodecan-9-yl-xanthogenate
-
i.e. D609, decreases enzyme activity an sphingomyelin levels in different human cell lines in vivo
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
tricyclodecan-9-yl-xanthogenate
-
tricyclodecane-9-yl xanthogenate
-
tumor necrosis factor-alpha
-
-
-
Zn2+
-
0.5 mM, about 95% inhibition
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
inhibitor of isoform SGMS2 with good selectivity against SGMS1
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
inhibitor of isoform SGMS2 with good selectivity against SGMS1; potent and selective inhibitor of isoform SGMS2. A repeated treatment in mice leads to significant reduction in hepatic sphingomyelin levels
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
-
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
i.e. D2, development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of C6-NBD-Cer and C6-NBDCerPCho in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, overview
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
inhibitor of isoform SGMS2 with good selectivity against SGMS1
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
inhibitor of isoform SGMS2 with good selectivity against SGMS1
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
-
D609
-
D609
-
complete in inhibition at 0.35 mM
D609
-
i.e. potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
inhibitor of isoform SGMS2 with good selectivity against SGMS1
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
-
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
inhibitor of isoform SGMS2 with good selectivity against SGMS1
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
inhibitor of isoform SGMS2 with good selectivity against SGMS1
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
tricyclodecan-9-yl-xanthogenate
i.e. D609; i.e. D609
-
tricyclodecan-9-yl-xanthogenate
-
sphingomyelin synthase is a potential target for tricyclodecan-9-yl-xanthogenate (D609) and inhibition of sphingomyelin synthase may contribute to D609-induced cell death via modulation of the cellular levels of ceramide and diacylglycerol
-
tricyclodecan-9-yl-xanthogenate
-
i.e. D609
-
tricyclodecan-9-yl-xanthogenate
-
-
tricyclodecan-9-yl-xanthogenate
i.e. D609
-
tricyclodecan-9-yl-xanthogenate
-
i.e. D609
-
tricyclodecan-9-yl-xanthogenate
i.e. D609
-
tricyclodecan-9-yl-xanthogenate
-
i.e. D609
-
tricyclodecane-9-yl xanthogenate
i.e. D609; i.e. D609
-
tricyclodecane-9-yl xanthogenate
i.e. D609; i.e. D609
-
additional information
-
photosensitizer Pc 4, PDT, induces inhibition of SMS in Jurkat cells
-
additional information
structure-based virtual screening, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as sphingomyelin synthase 1 inhibitors, molecular docking studies and interaction modes of SMS1 inhibitors with the active site of SMS1, overview
-
additional information
design of dual inhibitors of secretory phospholipase A2 and sphingomyelin synthase by linking or fusing sphingomyelin synthase inhibitor fragment Ly18 (N-pyridine-3-amide moiety) with phospholipase A2 inhibitor fragment (indole-3-acetamide structure) by 3-6 carbon chain
-
additional information
-
disturbance of cholesterol homoeostasis by 3-beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one, i.e. U18666A, indirectly inhibits sphingomyelin biosynthesis, overview
-
additional information
turpentine leads to downregulation of SMS1 expression in liver
-
additional information
-
turpentine leads to downregulation of SMS1 expression in liver
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000003 - 0.00085
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.0000065 - 0.001
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.0000022 - 0.0024
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.00099
2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0028
2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00069
2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00089
2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00067
2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00047
2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0013
2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00074
2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0015
2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0011
2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00088
2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0035
2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0015
2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0031
2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0038
2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0014
2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0016
2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0116
2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0041
2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00043
2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00052
2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00067
2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0011
2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.00074
2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0135 - 0.025
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
0.1
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(2-(trifluoromethoxy)phenyl)acetamide
Homo sapiens
pH 7.4, 37°C
0.1
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(o-tolyl)acetamide
Homo sapiens
pH 7.4, 37°C
0.0147
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-phenylacetamide
Homo sapiens
pH 7.4, 37°C
0.0117
2-(benzyloxy)-N-(pyridin-2-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0032
2-(benzyloxy)-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0017
2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine
Homo sapiens
pH 7.4, 37°C
0.0253
2-[[2-((5-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)pentyl)oxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0287
2-[[2-((6-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)hexyl)oxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0265
2-[[2-(3-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)propoxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.0617
2-[[2-(4-(3-(2-amino-2-oxoethyl)-5-methoxy-2-methyl-1H-indol-1-yl)butoxy)benzyl]oxy]-N-(pyridin-3-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.1
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-(pyridin-4-yl)benzamide
Homo sapiens
pH 7.4, 37°C
0.1
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-phenethylbenzamide
Homo sapiens
pH 7.4, 37°C
0.0000077 - 0.0034
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.00061 - 0.015
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
0.1
N-(2-cyanophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0142
N-(2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.1
N-(2-nitrophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.000016 - 0.014
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-((2-phenylpyridin-4-yl)methoxy)-1,2-dihydroquinoline-3-carboxamide
0.00012 - 0.025
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
0.00095
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(pyrrolidin-1-yl)-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.0156
N-(3-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0092
N-(3-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0021
N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.1
N-(4-chlorobenzyl)-2-(4-(N-(3-phenylpropyl)sulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.05
N-(4-chlorobenzyl)-2-(4-(N-(4-chlorobenzyl)sulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0052
N-(4-chlorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.1
N-(4-chlorobenzyl)-2-(4-(N-phenylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0066
N-(4-chlorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.1
N-(4-fluoro-2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0081
N-(4-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0105
N-(4-fluorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0059
N-(4-methoxybenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.05
N-(4-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0021
N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide
Homo sapiens
pH 7.4, 37°C
0.0231
N-benzyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.05
N-phenethyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide
Homo sapiens
pH 7.4, 37°C
0.0021
N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide
Homo sapiens
pH 7.4, 37°C
0.000032 - 0.01
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.000019 - 0.019
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
0.219 - 0.4027
tricyclodecan-9-yl-xanthogenate
-
0.056
tricyclodecane-9-yl xanthogenate
Homo sapiens
pH 7.5, 23°C
-
0.000003
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.000047
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.00085
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.0000065
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.001
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.0000022
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.000045
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.0024
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.0135
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
Mus musculus
SMS2, pH and temperature not specified in the publication
0.0245
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
Mus musculus
SMS in liver homogenate, pH and temperature not specified in the publication
0.025
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
Homo sapiens
pH 7.4, 37°C
0.0000077
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.00003
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.0034
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.00061
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.00066
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
Mus musculus
pH 7.5, 23°C
0.015
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.622
D609
Homo sapiens
isoform SMS1, in 50 mM TrisHCl (pH 7.4), at 22°C
1.065
D609
Homo sapiens
isoform SMS2, in 50 mM TrisHCl (pH 7.4), at 22°C
0.000016
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-((2-phenylpyridin-4-yl)methoxy)-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.014
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-((2-phenylpyridin-4-yl)methoxy)-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.00012
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.00024
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
Mus musculus
pH 7.5, 23°C
0.025
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
Homo sapiens
pH 7.5, 23°C
0.000032
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.00013
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.01
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.000019
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.000091
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.019
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Homo sapiens
pH 7.5, 23°C
0.219
tricyclodecan-9-yl-xanthogenate
Homo sapiens
pH 7.4, 37°C
-
0.4027
tricyclodecan-9-yl-xanthogenate
Mus musculus
pH and temperature not specified in the publication
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Vivekananda, J.; Smith, D.; King, R.J.
Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase
Am. J. Physiol.
281
L98-L107
2001
Homo sapiens
brenda
Albi, E.; La Porta, C.A.; Cataldi, S.; Magni, M.V.
Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells
Arch. Biochem. Biophys.
438
156-161
2005
Homo sapiens, Mus musculus
brenda
Hanada, K.; Horii, M.; Akamatsu, Y.
Functional reconstitution of sphingomyelin synthase in Chinese hamster ovary cell membranes
Biochim. Biophys. Acta
1086
151-156
1991
Cricetulus griseus
brenda
Allan, D.; Obradors, M.J.
Enzyme distributions in subcellular fractions of BHK cells infected with Semliki forest virus: evidence for a major fraction of sphingomyelin synthase in the trans-Golgi network
Biochim. Biophys. Acta
1450
277-287
1999
Mesocricetus auratus
brenda
Miro-Obradors, M.J.; Osada, J.; Aylagas, H.; Sanchez-Vegazo, I.; Palacios-Alaiz, E.
Microsomal sphingomyelin accumulation in thioacetamide-injured regenerating rat liver: involvement of sphingomyelin synthase activity
Carcinogenesis
14
941-946
1993
Rattus norvegicus
brenda
Huitema, K.; van den Dikkenberg, J.; Brouwers, J.F.H.M.; Holthuis, J.C.M.
Identification of a family of animal sphingomyelin synthases
EMBO J.
23
33-44
2004
Caenorhabditis elegans (Q20735), Caenorhabditis elegans (Q9U3D4), Caenorhabditis elegans, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens, Mus musculus (Q8VCQ6), Mus musculus
brenda
Meng, A.; Luberto, C.; Meier, P.; Bai, A.; Yang, X.; Hannun, Y.A.; Zhou, D.
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells
Exp. Cell Res.
292
385-392
2004
Homo sapiens
brenda
Albi, E.; Magni, M.V.
Sphingomyelin synthase in rat liver nuclear membrane and chromatin
FEBS Lett.
460
369-372
1999
Rattus norvegicus
brenda
Albi, E.; Lazzarini, R.; Magni, M.V.
Reverse sphingomyelin-synthase in rat liver chromatin
FEBS Lett.
549
152-156
2003
Rattus norvegicus
brenda
Yang, Z.; Khoury, C.; Jean-Baptiste, G.; Greenwood, M.T.
Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast
FEMS Yeast Res.
6
751-762
2006
Mus musculus (Q8VCQ6), Mus musculus
brenda
Guillen, N.; Navarro, M.A.; Surra, J.C.; Arnal, C.; Fernandez-Juan, M.; Cebrian-Perez, J.A.; Osada, J.
Cloning, characterization, expression and comparative analysis of pig Golgi membrane sphingomyelin synthase 1
Gene
388
117-124
2007
Sus scrofa (A0AAS4), Sus scrofa
brenda
van Helvoort, A.; van't Hof, W.; Ritsema, T.; Sandra, A.; van Meer, G.
Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial (Madin-Darby canine kidney) cells. Evidence for the reverse action of a sphingomyelin synthase
J. Biol. Chem.
269
1763-1769
1994
Canis lupus familiaris
brenda
Luberto, C.; Hannun, Y.A.
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
J. Biol. Chem.
273
14550-14559
1998
Homo sapiens
brenda
Luberto, C.; Stonehouse, M.J.; Collins, E.A.; Marchesini, N.; El-Bawab, S.; Vasil, A.I.; Vasil, M.L.; Hannun, Y.A.
Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme
J. Biol. Chem.
278
32733-32743
2003
Pseudomonas aeruginosa
brenda
Yamaoka, S.; Miyaji, M.; Kitano, T.; Umehara, H.; Okazaki, T.
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells
J. Biol. Chem.
279
18688-18693
2004
Homo sapiens (Q86VZ5), Homo sapiens
brenda
Tafesse, F.G.; Ternes, P.; Holthuis, J.C.
The multigenic sphingomyelin synthase family
J. Biol. Chem.
281
29421-29425
2006
Mus musculus, Pseudomonas aeruginosa, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
brenda
Elmendorf, H.G.; Haldar, K.
Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes
J. Cell Biol.
124
449-462
1994
Plasmodium falciparum
brenda
Lee, N.P.; Mruk, D.D.; Xia, W.; Cheng, C.Y.
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes
J. Endocrinol.
192
17-32
2007
Rattus norvegicus, Rattus norvegicus (Q4JM44)
brenda
Dong, J.; Liu, J.; Lou, B.; Li, Z.; Ye, X.; Wu, M.; Jiang, X.C.
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice
J. Lipid Res.
47
1307-1314
2006
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1), Mus musculus
brenda
Hailemariam, T.K.; Huan, C.; Liu, J.; Li, Z.; Roman, C.; Kalbfeisch, M.; Bui, H.H.; Peake, D.A.; Kuo, M.; Cao, G.; Wadgaonkar, R.; Jiang, X.
Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
Arterioscler. Thromb. Vasc. Biol.
28
1519-1526
2008
Homo sapiens, Mus musculus
brenda
Separovic, D.; Hanada, K.; Maitah, M.Y.; Nagy, B.; Hang, I.; Tainsky, M.A.; Kraniak, J.M.; Bielawski, J.
Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage
Biochem. Biophys. Res. Commun.
358
196-202
2007
Homo sapiens
brenda
Van der luit, A.H.; Budde, M.; Zerp, S.; Caan, W.; Klarenbeek, J.B.; Verheij, M.; van Blitterswijk, W.J.
Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts
Biochem. J.
401
541-549
2007
Mus musculus
brenda
Villani, M.; Subathra, M.; Im, Y.B.; Choi, Y.; Signorelli, P.; Del Poeta, M.; Luberto, C.
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
Biochem. J.
414
31-41
2008
Homo sapiens
brenda
Li, Z.; Hailemariam, T.K.; Zhou, H.; Li, Y.; Duckworth, D.C.; Peake, D.A.; Zhang, Y.; Kuo, M.S.; Cao, G.; Jiang, X.C.
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization
Biochim. Biophys. Acta
1771
1186-1194
2007
Homo sapiens
brenda
Yeang, C.; Varshney, S.; Wang, R.; Zhang, Y.; Ye, D.; Jiang, X.C.
The domain responsible for sphingomyelin synthase (SMS) activity
Biochim. Biophys. Acta
1781
610-617
2008
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
brenda
Dmitrieva, V.G.; Torshina, E.V.; Yuzhakov, V.V.; Povarova, O.V.; Skvortsova, V.I.; Limborska, S.A.; Dergunova, L.V.
Expression of sphingomyelin synthase 1 gene in rat brain focal ischemia
Brain Res.
1188
222-227
2008
Rattus norvegicus
brenda
Separovic, D.; Semaan, L.; Tarca, A.L.; Awad Maitah, M.Y.; Hanada, K.; Bielawski, J.; Villani, M.; Luberto, C.
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage
Exp. Cell Res.
314
1860-1868
2008
Homo sapiens
brenda
Jin, Z.X.; Huang, C.R.; Dong, L.; Goda, S.; Kawanami, T.; Sawaki, T.; Sakai, T.; Tong, X.P.; Masaki, Y.; Fukushima, T.; Tanaka, M.; Mimori, T.; Tojo, H.; Bloom, E.T.; Okazaki, T.; Umehara, H.
Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells
Int. Immunol.
20
1427-1437
2008
Homo sapiens
brenda
Tafesse, F.G.; Huitema, K.; Hermansson, M.; van der Poel, S.; van den Dikkenberg, J.; Uphoff, A.; Somerharju, P.; Holthuis, J.C.
Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells
J. Biol. Chem.
282
17537-17547
2007
Homo sapiens, Mus musculus
brenda
Liu, J.; Zhang, H.; Li, Z.; Hailemariam, T.K.; Chakraborty, M.; Jiang, K.; Qiu, D.; Bui, H.H.; Peake, D.A.; Kuo, M.S.; Wadgaonkar, R.; Cao, G.; Jiang, X.C.
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice
Arterioscler. Thromb. Vasc. Biol.
29
850-856
2009
Mus musculus
brenda
Tani, M.; Kuge, O.
Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes
Biochem. Biophys. Res. Commun.
381
328-332
2009
Homo sapiens
brenda
Liu, J.; Huan, C.; Chakraborty, M.; Zhang, H.; Lu, D.; Kuo, M.S.; Cao, G.; Jiang, X.C.
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice
Circ. Res.
105
295-303
2009
Mus musculus
brenda
Vacaru, A.M.; Tafesse, F.G.; Ternes, P.; Kondylis, V.; Hermansson, M.; Brouwers, J.F.; Somerharju, P.; Rabouille, C.; Holthuis, J.C.
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
J. Cell Biol.
185
1013-1027
2009
Homo sapiens
brenda
Ding, T.; Li, Z.; Hailemariam, T.; Mukherjee, S.; Maxfield, F.; Wu, M.; Jiang, X.
SMS overexpression and knockdown: Impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis
J. Lipid Res.
49
376-385
2008
Homo sapiens
brenda
Ternes, P.; Brouwers, J.F.; van den Dikkenberg, J.; Holthuis, J.C.
Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
J. Lipid Res.
50
2270-2277
2009
Homo sapiens
brenda
Chen, Y.; Yurek, D.A.; Yu, L.; Wang, H.; Ehsani, M.E.; Qian, Y.W.; Konrad, R.J.; Jiang, X.C.; Kuo, M.S.; Cao, G.; Wang, J.
Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry
Anal. Biochem.
438
61-66
2013
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens
brenda
Kidani, Y.; Ohshima, K.; Sakai, H.; Kohno, T.; Baba, A.; Hattori, M.
Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation
Biochem. Biophys. Res. Commun.
417
1014-1017
2012
Mus musculus
brenda
Burns, T.A.; Subathra, M.; Signorelli, P.; Choi, Y.; Yang, X.; Wang, Y.; Villani, M.; Bhalla, K.; Zhou, D.; Luberto, C.
Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene
J. Lipid Res.
54
794-805
2013
Homo sapiens
brenda
Zhao, Y.R.; Dong, J.B.; Li, Y.; Wu, M.P.
Sphingomyelin synthase 2 over-expression induces expression of aortic inflammatory biomarkers and decreases circulating EPCs in ApoE KO mice
Life Sci.
90
867-873
2012
Homo sapiens
brenda
Man, C.; Lee, J.
Molecular cloning, sequence characterization, and tissue expression analysis of chicken sphingomyelin synthase 1 (SMS1)
Mol. Cell. Biochem.
357
353-361
2011
Gallus gallus (Q7T3T4), Gallus gallus
brenda
Asano, S.; Kitatani, K.; Taniguchi, M.; Hashimoto, M.; Zama, K.; Mitsutake, S.; Igarashi, Y.; Takeya, H.; Kigawa, J.; Hayashi, A.; Umehara, H.; Okazaki, T.
Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
Mol. Cell. Biol.
32
3242-3252
2012
Mus musculus
brenda
Yeang, C.; Ding, T.; Chirico, W.J.; Jiang, X.C.
Subcellular targeting domains of sphingomyelin synthase 1 and 2
Nutr. Metab.
8
89
2011
Homo sapiens (Q86VZ5), Mus musculus (Q9D4B1)
brenda
Qureshi, A.; Subathra, M.; Grey, A.; Schey, K.; Del Poeta, M.; Luberto, C.
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans
PLoS ONE
5
e15587
2010
Homo sapiens
brenda
Subathra, M.; Qureshi, A.; Luberto, C.
Sphingomyelin synthases regulate protein trafficking and secretion
PLoS ONE
6
e23644
2011
Homo sapiens, Rattus norvegicus
brenda
Barcelo-Coblijn, G.; Martin, M.L.; de Almeida, R.F.; Noguera-Salva, M.A.; Marcilla-Etxenike, A.; Guardiola-Serrano, F.; Lueth, A.; Kleuser, B.; Halver, J.E.; Escriba, P.V.
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
Proc. Natl. Acad. Sci. USA
108
19569-19574
2011
Homo sapiens
brenda
Piotto, S.; Concilio, S.; Bianchino, E.; Iannelli, P.; Lopez, D.J.; Teres, S.; Ibarguren, M.; Barcelo-Coblijn, G.; Martin, M.L.; Guardiola-Serrano, F.; Alonso-Sande, M.; Funari, S.S.; Busquets, X.; Escriba, P.V.
Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets
Biochim. Biophys. Acta
1838
1628-1637
2014
Homo sapiens
brenda
Sugimoto, M.; Shimizu, Y.; Zhao, S.; Ukon, N.; Nishijima, K.; Wakabayashi, M.; Yoshioka, T.; Higashino, K.; Numata, Y.; Okuda, T.; Tamaki, N.; Hanamatsu, H.; Igarashi, Y.; Kuge, Y.
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
Biochim. Biophys. Acta
1861
688-702
2016
Mus musculus (Q9D4B1), Mus musculus C57BL/6N (Q9D4B1)
brenda
Li, Y.L.; Qi, X.Y.; Jiang, H.; Deng, X.D.; Dong, Y.P.; Ding, T.B.; Zhou, L.; Men, P.; Chu, Y.; Wang, R.X.; Jiang, X.C.; Ye, D.Y.
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors
Bioorg. Med. Chem.
23
6173-6184
2015
Homo sapiens (Q86VZ5)
brenda
Hu, S.; Ding, Y.; Song, D.; Chen, Q.; Yan, N.
Construction and identification of RNA interference vector of human sphingomyelin synthase
Fudan Univ. J. Med. Sci.
40
584-588
2013
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
-
brenda
Thomaseth, C.; Weber, P.; Hamm, T.; Kashima, K.; Radde, N.
Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism
J. Theor. Biol.
337
174-180
2013
Homo sapiens (Q86VZ5)
brenda
Huang, T.; Li, X.; Hu, S.; Zhao, B.; Chen, P.; Liu, X.; Ye, D.; Cheng, N.
Analysis of fluorescent ceramide and sphingomyelin analogs: a novel approach for in vivo monitoring of sphingomyelin synthase activity
Lipids
49
1071-1079
2014
Mus musculus (Q9D4B1)
brenda
Hu, S.; Ding, Y.; Gong, J.; Yan, N.
Sphingomyelin synthase 2 affects CD14-associated induction of NF kappaB by lipopolysaccharides in acute lung injury in mice
Mol. Med. Rep.
14
3301-3306
2016
Mus musculus (Q9D4B1), Mus musculus
brenda
Hsiao, J.H.; Fu, Y.; Hill, A.F.; Halliday, G.M.; Kim, W.S.
Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation
PLoS ONE
8
e74016
2013
Homo sapiens (Q86VZ5), Homo sapiens
brenda
Deng, X.; Sun, H.; Gao, X.; Gong, H.; Lu, W.; Chu, Y.; Zhou, L.; Ye., D.
Development, validation, and application of a novel method for mammalian sphingomyelin synthase activity measurement
Anal. Lett.
45
1581-1589
2012
Mus musculus
-
brenda
Sakamoto, H.; Yoshida, T.; Sanaki, T.; Shigaki, S.; Morita, H.; Oyama, M.; Mitsui, M.; Tanaka, Y.; Nakano, T.; Mitsutake, S.; Igarashi, Y.; Takemoto, H.
Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response
Biochem. Biophys. Res. Commun.
482
202-207
2017
Mus musculus (Q9D4B1), Mus musculus
brenda
Prymas, K.; Swiatkowska, A.; Traczyk, G.; Ziemlinska, E.; Dziewulska, A.; Ciesielska, A.; Kwiatkowska, K.
Sphingomyelin synthase activity affects TRIF-dependent signaling of Toll-like receptor 4 in cells stimulated with lipopolysaccharide
Biochim. Biophys. Acta
1865
158549
2020
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1)
brenda
Yukawa, T.; Nakahata, T.; Okamoto, R.; Ishichi, Y.; Miyamoto, Y.; Nishimura, S.; Oikawa, T.; Kubo, K.; Adachi, R.; Satomi, Y.; Nakakariya, M.; Amano, N.; Kamaura, M.; Matsunaga, N.
Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor
Bioorg. Med. Chem.
28
115376
2020
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Mus musculus (Q9D4B1)
brenda
Adachi, R.; Ogawa, K.; Matsumoto, S.; Satou, T.; Tanaka, Y.; Sakamoto, J.; Nakahata, T.; Okamoto, R.; Kamaura, M.; Kawamoto, T.
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors
Eur. J. Med. Chem.
136
283-293
2017
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens
brenda
Li, Y.; Huang, T.; Lou, B.; Ye, D.; Qi, X.; Li, X.; Hu, S.; Ding, T.; Chen, Y.; Cao, Y.; Mo, M.; Dong, J.; Wei, M.; Chu, Y.; Li, H.; Jiang, X.; Cheng, N.; Zhou, L.
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor
Eur. J. Med. Chem.
163
864-882
2019
Homo sapiens (Q8NHU3)
brenda
Shi, X.; Zhang, H.; Chen, M.; Zhang, Y.; Zhu, M.; Zhang, M.; Li, F.; Wratten, S.; Zhou, W.; Mao, C.; Zhu, Z.
Two sphingomyelin synthase homologues regulate body weight and sphingomyelin synthesis in female brown planthopper, N.xa0lugens (Stal)
Insect Mol. Biol.
28
253-263
2019
Nilaparvata lugens
brenda
Zhang, P.; Hua, L.; Hou, H.; Du, X.; He, Z.; Liu, M.; Hu, X.; Yan, N.
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/beta-catenin signaling pathway
Int. J. Mol. Med.
42
3344-3354
2018
Homo sapiens (Q8NHU3)
brenda
Gong, H.; Zhou, L.; Ye, D.; Gao, X.; Li, Y.; Qi, X.; Chu, Y.
Novel dual inhibitors of secretory phospholipase A2 and sphingomyelin synthase Design, synthesis and evaluation
Lett. Drug Des. Discov.
13
1025-1032
2016
Homo sapiens (Q8NHU3)
-
brenda
Li, X.; Luo, T.; Li, H.; Yan, N.
Sphingomyelin synthase 2 participate in the regulation of sperm motility and apoptosis
Molecules
25
4231
2020
Homo sapiens (Q8NHU3), Homo sapiens
brenda
Wittmann, A.; Grimm, M.O.; Scherthan, H.; Horsch, M.; Beckers, J.; Fuchs, H.; Gailus-Durner, V.; Hrabe de Angelis, M.; Ford, S.J.; Burton, N.C.; Razansky, D.; Truembach, D.; Aichler, M.; Walch, A.K.; Calzada-Wack, J.; Neff, F.; Wurst, W.; Hartmann, T.; Floss, T.
Sphingomyelin synthase 1 is essential for male fertility in mice
PLoS ONE
11
e0164298
2016
Mus musculus (Q8VCQ6), Mus musculus
brenda