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GDP-alpha-L-fucose + fetuin
GDP + 3-alpha-L-fucosyl-fetuin
-
-
-
-
?
GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R
GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R
-
-
-
-
ir
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-3GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-3[Fucalpha1-3]GlcNAcbeta-R
-
4% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAc
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc
-
28% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAcbeta-R
-
best substrate
-
-
?
GDP-beta-fucose + fetuin
GDP + fucosylated fetuin
-
-
-
-
?
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-L-Asn
GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-L-Asn
-
-
-
-
?
GDP-beta-L-fucose + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-GlcNAc-beta-(1->)-N?Asn?peptide
GDP + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-[(Fuc-alpha-(1->3)]-GlcNAc-beta-(1->)-N?Asn?peptide
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(ucalpha(1->6)G)cNAcbeta(1->)N-Asn-peptide(NAc)
?
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)]GlcNAc
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
GDP-beta-L-fucose + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)[Fucalpha(1->3)]GlcNAc
-
-
-
?
GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
?
GDP-fucose + alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
-
the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
-
?
GDP-fucose + asialo-alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-fucose + asialo/agalacto-glycopeptide-F2
GDP + alpha1-3-fucosylated glycopeptide
-
asialo/agalacto-glycopeptide-F2: from human fibrinogen
-
?
GDP-fucose + asialo/agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
-
asialo/agalacto-glycopeptide-IgGF6: from core alpha1-6-fucosylated human IgG
-
?
GDP-fucose + asialofetuin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-fucose + asialotransferrin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-fucose + bisected agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
-
-
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
GDP-fucose + dabsylated-GalGal-peptide
GDP + alpha1-3-fucosylated peptide
-
0.7% relative activity with recombinant enzyme
-
?
GDP-fucose + dabsylated-GalGn-peptide
GDP + alpha1-3-fucosylated peptide
-
50% relative activity with recombinant enzyme
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
GDP-fucose + dansyl-GnGnF6
GDP + alpha1-3-fucosylated glycopeptide
-
prefucosylation of GnGn with chicken heart extract results in a superior conversion of GnGnF6 by FucTA than with GnGn, 100% relative conversion
-
?
GDP-fucose + dansylated mono-beta1,3-galactosylated glycopeptide
GDP + alpha1-3-fucosylated glycopeptide
-
FucTA gene
-
?
GDP-fucose + fetuin
GDP + alpha1-3 fucosylated glycoprotein
-
the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
-
?
GDP-fucose + Galbeta1-4GlcNAcalpha-p-nitrophenol
Galbeta1-4(Fucalpha1-3)GlcNAcalpha-p-nitrophenol
-
CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
-
CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + GalGal-N-glycan
GDP + alpha1-3-fucosylated GalGal-N-glycan
-
4.6% relative conversion, FucTA gene
-
?
GDP-fucose + GalGalF6-N-glycan
GDP + alpha1-3-fucosylated GalGalF6-N-glycan
-
19.8% relative conversion, FucTA gene
-
?
GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
-
LDNT, CFET-2
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4 (Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-N-Asn-peptide(Nac)
GDP + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-N-Asn-peptide(Nac)
-
-
the product shows a difucosylated structure with two Fuc residues at the Asn-bound GlcNAc residue, 40% yield
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)[Fucalpha1-6]GlcNAcbeta1-Asn
-
difucosylated glycan structure
-
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GnGn-oligosaccharide
GDP + alpha1-3 fucosylated GnGn-oligosaccharide
-
93% relative activity of pure enzyme
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3 fucosylated peptide
-
100% relative activity of pure enzyme and of crude extract
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3-fucosylated peptide
-
100% relative activity with recombinant enzyme
-
?
GDP-fucose + GnGnF6-oligosaccharide
GDP + alpha1-3 fucosylated oligosaccharide
-
95% relative activity of pure enzyme
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
GDP-fucose + M5Gn-Asn
GDP + alpha1-3-fucosylated M5Gn-Asn
-
71% relative activity with recombinant enzyme
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcb1-Asn
-
CFET-1
-
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
CFET-1, Nglycan pentasaccharide core acceptor as substrate
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + 3-fucosyl-N-acetyllactosamine
-
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
GDP-fucose + N-[2-(2-pyridylamino)ethyl]-succinamic acid-labeled biantennary oligosaccharides
GDP + ?
-
-
-
?
GDP-fucose + transferrin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-L-Fuc + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-fucose alpha-1,3-bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
-
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,6)GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)(Fucalpha1,6)GlcNAc
-
preferred substrate
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
GDP-L-fucose + LacNAc-C8
GDP + alpha1,3-fucosylated LacNAc-C8
-
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
GDP-L-Gal + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-galactose bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
-
-
-
?
additional information
?
-
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
-
FucTA gene, dabsylated glycopeptide derived from fibrin carrying a GnGn oligosaccharide
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
-
GnGn is the most suitable substrate for FucTA
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
-
FucTA gene, dansylated glycopeptide derived from IgG, 40% relative conversion
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
-
-
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
-
87% relative activity with recombinant enzyme
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
-
99% relative activity of pure enzyme and 70% relative activity of crude extract
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
-
FucT involved in production of the Lewis x trisaccharide, the major component of the bacterias lipopolysaccharides
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
-
FucT involved in production of the Lewis x trisaccharide, the major component of the bacterias lipopolysaccharides
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
-
-
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
Schistosoma sp.
-
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
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?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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additional information
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substrate specificity of FucTA of Apis mellifera is similar to Drosophila melanogaster FucTA
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additional information
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FucTA gene, amongst the dansyl glycopeptides tested, only those with one free non-reducing terminal N-acetyl-glucosamine residue act as substrates: specifically GnGn lacking one GlcNAc, GnGn substituted with one galactose residue or GnGn substituted with one Lewis-a epitope
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additional information
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the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic
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additional information
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the enzyme is able to fucosylate N-glycan structures of human transferrin in vitro
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additional information
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alpha1-6-fucosylated glycans are better substrates than beta-1-4-galactosylated glycans, FucTA gene
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additional information
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substrate specificity, no activity with GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc, the recombinant enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
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additional information
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alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview
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additional information
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FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability
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additional information
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FucT-VII is essential for biosynthesis of selectin binding ligands in T-cells, H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells via the Raf-MEK-ERK pathway, but induction of FucT-VII requires the concomitant activation of at least 3 different signaling pathways, overview
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additional information
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sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells
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additional information
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the enzyme is essential for biosynthesis of selectin binding ligands in T-cells
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additional information
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the enzyme is responsible for the generation of functional P- and E-selectin ligands
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additional information
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the enzyme synthesizes functional selectin ligands on the surface of leukocytes
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additional information
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development of a sensitive cell-based assay system to monitor FucT-VII mediated sialyl Lewis biosynthesis
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additional information
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poorly active with Galbeta1-4GlcNAc-O-(CH2)8-COOCH3, Fucalpha1-2Galbeta1-4GlcNAcbeta-R, Galbeta1-3GlcNAcbeta-R, and Fucalpha1-2Galbeta1-3GlcNAcbeta-R
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additional information
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substrate specificities of wild-type and alpha 1,3 FucT motif mutants, overview
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additional information
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compounds lacking the peptide-linked GlNAc or outer arm GlcNAc do not serve as acceptors
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additional information
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the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans
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additional information
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Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes
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additional information
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FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin
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additional information
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the enzyme performs Lewis X carbohydrate structure synthesis on oligosaccharides, polylactosamine chains, and glycolipids in the brain with high alpha1,3-fucosyltransferase activity
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additional information
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Schistosoma sp.
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substrate specificity
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additional information
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Schistosoma sp.
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the native enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
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additional information
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the enzyme acts upon N-glycopeptides and related oligosaccharides with the glycan structure GlcNAc2Man3GlcNAc2, no transfer to N-glycans is observed when the terminal GlcNAc residues are either absent or substituted with galactose, N-acetyllactosamine, lacto-N-biose and N-acetylchito-oligosaccharides do not function as acceptors for the enzyme
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GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R
GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R
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GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc
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GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
additional information
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
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additional information
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the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic
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additional information
?
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alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview
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additional information
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FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability
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additional information
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FucT-VII is essential for biosynthesis of selectin binding ligands in T-cells, H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells via the Raf-MEK-ERK pathway, but induction of FucT-VII requires the concomitant activation of at least 3 different signaling pathways, overview
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additional information
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sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells
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additional information
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the enzyme is essential for biosynthesis of selectin binding ligands in T-cells
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additional information
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the enzyme is responsible for the generation of functional P- and E-selectin ligands
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additional information
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the enzyme synthesizes functional selectin ligands on the surface of leukocytes
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additional information
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the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans
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additional information
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Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes
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additional information
?
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FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin
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additional information
?
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the enzyme performs Lewis X carbohydrate structure synthesis on oligosaccharides, polylactosamine chains, and glycolipids in the brain with high alpha1,3-fucosyltransferase activity
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additional information
?
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Schistosoma sp.
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the native enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
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Adenocarcinoma
The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells.
Adenocarcinoma of Lung
Overexpression of alpha(1,3)-fucosyltransferase VII is sufficient for the acquisition of lung colonization phenotype in human lung adenocarcinoma HAL-24Luc cells.
Adenocarcinoma, Follicular
FUT7 promotes the malignant transformation of follicular thyroid carcinoma through ?1,3-fucosylation of EGF receptor.
Arthritis
Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis.
Arthritis, Juvenile
Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis.
Atherosclerosis
Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.
Atherosclerosis
Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice.
Breast Neoplasms
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Carcinogenesis
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII.
Carcinoma
alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma.
Carcinoma
Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion.
Carcinoma
Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells.
Carcinoma
FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data.
Carcinoma
Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells.
Carcinoma
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Carcinoma, Hepatocellular
FUT11 is a target gene of HIF1? that promotes the progression of hepatocellular carcinoma.
Carcinoma, Renal Cell
FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data.
Colitis
Exploring the Interplay of Barrier Function and Leukocyte Recruitment in Intestinal Inflammation by Targeting Fucosyltransferase VII and Trefoil Factor 3.
Colonic Neoplasms
Elevation of an alpha(1,3)fucosyltransferase activity correlated with apoptosis in the human colon adenocarcinoma cell line, HT-29.
Colonic Neoplasms
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Colorectal Neoplasms
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Dermatitis, Contact
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.
glycoprotein 3-alpha-l-fucosyltransferase deficiency
Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.
glycoprotein 3-alpha-l-fucosyltransferase deficiency
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.
glycoprotein 3-alpha-l-fucosyltransferase deficiency
Molecular analysis of plasma alpha 1,3-fucosyltransferase deficiency and development of the methods for its genotyping.
glycoprotein 3-alpha-l-fucosyltransferase deficiency
Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia.
glycoprotein 3-alpha-l-fucosyltransferase deficiency
The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.
Hypersensitivity
Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites.
Infections
Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.
Infections
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
Infections
Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.
Intestinal Neoplasms
[Glycosyltransferase genes for synthesis of Lewis antigens]
Leukemia
Glycosyltransferase activities in leukemic cells from patients and human leukemic cell lines.
Leukemia
UDP-GlcNAc:Galbeta1-->3GalNAc (GlcNAc to GalNAc) beta1-->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines.
Leukemia, Myeloid, Acute
Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia.
Leukemia, T-Cell
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element.
Lung Neoplasms
Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer.
Lymphatic Metastasis
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Lymphoma
Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.
Lymphoma, B-Cell
Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.
Melanoma
Expression of fucosyltransferases contributes to melanoma invasive phenotype.
Melanoma
Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides.
Neoplasm Metastasis
Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells.
Neoplasm Metastasis
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Neoplasm Metastasis
Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1.
Neoplasm Metastasis
Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
Neoplasm Metastasis
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Neoplasms
alpha(1,3)Fucosyltransferase expression in E-selectin-mediated binding of gastrointestinal tumor cells.
Neoplasms
alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma.
Neoplasms
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Neoplasms
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII.
Neoplasms
Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer.
Neoplasms
Expression of fucosyltransferases contributes to melanoma invasive phenotype.
Neoplasms
Fucosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas.
Neoplasms
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Neoplasms
FUT7 Promotes the Epithelial-Mesenchymal Transition and Immune Infiltration in Bladder Urothelial Carcinoma.
Neoplasms
Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells.
Neoplasms
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.
Neoplasms
Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1.
Neoplasms
Identification of hub genes and key pathways associated with the progression of gynecological cancer.
Neoplasms
Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides.
Neoplasms
Platelet-endothelial interactions in inflamed mesenteric venules.
Neoplasms
Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
Neoplasms
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Pancreatic Neoplasms
Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1.
Prostatic Neoplasms
Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells.
Skin Diseases
A miniaturized high-throughput screening assay for fucosyltransferase VII.
Tuberculosis
Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.
Tuberculosis, Pulmonary
Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.
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N219A
the mutant retains 1.2% of the wild type activity
N337A
the mutant retains 18.6% of the wild type activity
R226A
the mutation leads to a complete loss of activity
S218A
the mutation completely abolishes the enzyme activity
S253A
the mutant retains 35.6% of the wild type activity
S483A
the mutant retains 32.2% of the wild type activity
T339A
the mutant retains 12.1% of the wild type activity
T422A
the mutant retains 36.5% of the wild type activity
Y243A
the mutant retains 9.8% of the wild type activity
D303E
the mutant retains 23.8% of the wild type activity
N194Q
glycosylation site mutant with less than 1% of wild type activity
S243A
the mutant retains 16.2% of the wild type activity
T361A
the mutant retains 24.3% of the wild type activity
E249A
-
FucT 45, no activity
E249D
-
FucT 45, no activity
E249Q
-
FucT 45, no activity
E95A
-
FucT 45, no activity
E95D
-
FucT 45, no activity
K250A
-
FucT 45, no activity
L202M
-
to introduce methionine
R195A
-
FucT 45, no activity
E249A
-
FucT 45, no activity
-
E249D
-
FucT 45, no activity
-
E249Q
-
FucT 45, no activity
-
K250A
-
FucT 45, no activity
-
Y246A
-
FucT 45, active
-
E247A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, below 1% activity compared to the wild-type FucT VI
E257A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, below 1% activity compared to the wild-type FucT VI
F242A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, below 1% activity compared to the wild-type FucT VI
F246A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, 7% activity compared to the wild-type FucT VI
K241A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, low expression level in COS-7 cells, below 1% activity compared to the wild-type FucT VI
K258A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, inactive mutant
L244A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, 7% activity compared to the wild-type FucT VI
N248A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, below 1% activity compared to the wild-type FucT VI
S249A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, 57% activity compared to the wild-type FucT VI
T256A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, below 1% activity compared to the wild-type FucT VI
Y240A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, 14% activity compared to the wild-type FucT VI
Y254A
-
site-directed mutagenesis of a residue from the conserved alpha 1,3 FucT motif, inactive mutant
additional information
structural analysis of the FT of Helicobacter pylori by systematic C-terminal truncation reveals that up to 80 residues, including the region rich in hydrophobic and positively charged residues (434-478) and 5 of the 10 tandem repeats of 7 amino acids each (399-433) can be removed without significant change in structure and catalysis, half of the heptad repeats required to maintain both the secondary and native quaternary structures, systematic deletion of the C-terminus considerably improves the solubility of the protein, truncated forms are highly specific for type 2 sugar substrates that contain the Galbeta-1,4-GlcNAc structure, type 1 substrate Galbeta-1,3-GlcNAc is not accepted
additional information
-
structural analysis of the FT of Helicobacter pylori by systematic C-terminal truncation reveals that up to 80 residues, including the region rich in hydrophobic and positively charged residues (434-478) and 5 of the 10 tandem repeats of 7 amino acids each (399-433) can be removed without significant change in structure and catalysis, half of the heptad repeats required to maintain both the secondary and native quaternary structures, systematic deletion of the C-terminus considerably improves the solubility of the protein, truncated forms are highly specific for type 2 sugar substrates that contain the Galbeta-1,4-GlcNAc structure, type 1 substrate Galbeta-1,3-GlcNAc is not accepted
additional information
-
enzyme-deficient FucTVII-/- mice show contact hypersensitivity CHS deficiency resulting in strong or nearly complete deficiency in the complement of naive T-lymphocytes in lymph nodes for antigen-dependent activation, expansion, differentiation, and dissemination, enzyme deficiency also leads to deletion of E- and P-selectin ligands expression by Th1 and T cytotoxic 1 lymphocytes, and to annulation of T-cell trafficking
additional information
-
mice deficient in alpha(1,3)-fucosyltransferase-IV, i.e. FucT IV-/- mice, show a normal leukocyte rolling fraction, but increased rolling velocity, mice deficient in alpha(1,3)-fucosyltransferase-VII, i.e. FucT VII-/- mice, show a reduced leukocyte rolling fraction and increased rolling velocity
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Wilson, I.B.H.; Rendic, D.; Freilinger, A.; Dumic, J.; Altmann, F.; Mucha, J.; Mller, S.; Hauser, M.T.
Cloning and expression of alpha1,3-fucosyltransferase homologues from Arabidopsis thaliana
Biochim. Biophys. Acta
1527
88-96
2001
Arabidopsis thaliana
brenda
Fabini, G.; Freilinger, A.; Altmann, F.; Wilson, I.B.H.
Identification of core alpha1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseradish peroxidase epitope
J. Biol. Chem.
276
28058-28067
2001
Drosophila melanogaster
brenda
Leiter, H.; Mucha, J.; Staudacher, E.; Grimm, R.; Glossl, J.; Altmann, F.
Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase from mung beans
J. Biol. Chem.
274
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1999
Vigna radiata
brenda
Van Tetering, A.; Schiphorst, W.E.C.M.; van den Eijnden, D.H.; van Die, I.
Characterization of core alpha1-3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex type N-glycans
FEBS Lett.
461
311-314
1999
Lymnaea stagnalis
brenda
Staudacher, E.; Altmann, F.; Glossl, J.; M"rz, L.; Schachter, H.; Kamerling, J.P.; Hrd, K.; Vliegenthart, J.F.G.
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine
Eur. J. Biochem.
199
745-751
1991
Apis mellifera
brenda
Scudder, P.R.; Chantler, E.N.
Glycosyltransferases of the human cervical epithelium. I. Characterization of a beta-galactoside alpha-2-L-fucosyltransferase and the identification of a beta-N-acetylglucosaminide alpha-3-L-fucosyltransferase
Biochim. Biophys. Acta
660
128-135
1981
Homo sapiens
brenda
Campbell, C.; Stanley, P.
The Chinese hamster ovary glycosylation mutants LEC11 and LEC12 express two novel GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferase enzymes
J. Biol. Chem.
259
11208-11214
1984
Cricetulus griseus
brenda
Staudacher, E.; Dalik, T.; Wawra, P.; Altmann, F.; Maerz, L.
Functional purification and characterization of a GDP-fucose: beta-N-acetylglucosamine (Fuc to Asn linked GlcNAc) alpha1,3-fucosyltransferase from mung beans
Glycoconj. J.
12
780-786
1995
Vigna radiata
brenda
Miyashiro, M.; Furuya, S.; Fujishige, K.; Sugita, T.
Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII
Biochem. Biophys. Res. Commun.
324
98-107
2004
Homo sapiens
brenda
Wang, Q.Y.; Guo, P.; Duan, L.L.; Shen, Z.H.; Chen, H.L.
alpha-1,3-Fucosyltransferase-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1
Cell. Mol. Life Sci.
62
171-178
2005
Homo sapiens
brenda
De Vries, T.; Yen, T.Y.; Joshi, R.K.; Storm, J.; Van den Eijnden, D.H.; Knegtel, R.M.A.; Bunschoten, H.; Joziasse, D.H.; Macher, B.A.
Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures
Glycobiology
11
423-432
2001
Homo sapiens
brenda
De Vries, T.; Storm, J.; Rotteveel, F.; Verdonk, G.; Van Duin, M.; Van den Eijnden, D.H.; Joziasse, D.H.; Bunschoten, H.
Production of soluble human alpha3-fucosyltransferase (FucT VII) by membrane targeting and in vivo proteolysis
Glycobiology
11
711-717
2001
Homo sapiens
brenda
Nishihara, S.; Iwasaki, H.; Nakajima, K.; Togayachi, A.; Ikehara, Y.; Kudo, T.; Kushi, Y.; Furuya, A.; Shitara, K.; Narimatsu, H.
Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain
Glycobiology
13
445-455
2003
Mus musculus
brenda
Jost, F.; de Vries, T.; Knegtel, R.M.; Macher, B.A.
Mutation of amino acids in the alpha 1,3-fucosyltransferase motif affects enzyme activity and Km for donor and acceptor substrates
Glycobiology
15
165-175
2005
Homo sapiens
brenda
Paschinger, K.; Staudacher, E.; Stemmer, U.; Fabini, G.; Wilson, I.B.
Fucosyltransferase substrate specificity and the order of fucosylation in invertebrates
Glycobiology
15
463-474
2005
Drosophila melanogaster, Schistosoma sp.
brenda
Weninger, W.; Ulfman, L.H.; Cheng, G.; Souchkova, N.; Quackenbush, E.J.; Lowe, J.B.; von Andrian, U.H.
Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
Immunity
12
665-676
2000
Mus musculus
brenda
Zisoulis, D.G.; Kansas, G.S.
H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells
J. Biol. Chem.
279
39495-39504
2004
Homo sapiens
brenda
Martinez, M.; Joffraud, M.; Giraud, S.; Baisse, B.; Bernimoulin, M.P.; Schapira, M.; Spertini, O.
Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII
J. Biol. Chem.
280
5378-5390
2005
Homo sapiens
brenda
Smithson, G.; Rogers, C.E.; Smith, P.L.; Scheidegger, E.P.; Petryniak, B.; Myers, J.T.; Kim, D.S.L.; Homeister, J.W.; Lowe, J.B.
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes
J. Exp. Med.
194
601-614
2001
Mus musculus
brenda
Wagers, A.J.; Kansas, G.S.
Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta1 through a p38 mitogen-activated protein kinase-dependent pathway
J. Immunol.
165
5011-5016
2000
Homo sapiens
brenda
De Benedetti, F.; Pignatti, P.; Biffi, M.; Bono, E.; Wahid, S.; Ingegnoli, F.; Chang, S.Y.; Alexander, H.; Massa, M.; Pistorio, A.; Martini, A.; Pitzalis, C.; Sinigaglia, F.; Rogge, L.
Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis
J. Rheumatol.
30
1611-1615
2003
Homo sapiens
brenda
Rendic, D.; Klaudiny, J.; Stemmer, U.; Schmidt, J.; Paschinger, K.; Wilson, I.B.
Towards abolition of immunogenic structures in insect cells: characterization of a honey-bee (Apis mellifera) multi-gene family reveals both an allergy-related core alpha1,3-fucosyltransferase and the first insect Lewis-histo-blood-group-related antigen-synthesizing enzyme
Biochem. J.
402
603
2007
Apis mellifera (Q05GU3)
brenda
Lin, S.W.; Yuan, T.M.; Li, J.R.; Lin, C.H.
Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability
Biochemistry
45
8108-8116
2006
Helicobacter pylori (O30511), Helicobacter pylori
brenda
Nguyen, K.; van Die, I.; Grundahl, K.M.; Kawar, Z.S.; Cummings, R.D.
Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family
Glycobiology
17
586-599
2007
Caenorhabditis elegans
brenda
Sun, H.Y.; Lin, S.W.; Ko, T.P.; Pan, J.F.; Liu, C.L.; Lin, C.N.; Wang, A.H.; Lin, C.H.
Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design
J. Biol. Chem.
282
9973-9982
2007
Helicobacter pylori, Helicobacter pylori NCTC11639
brenda
Strasser, R.; Stadlmann, J.; Schaehs, M.; Stiegler, G.; Quendler, H.; Mach, L.; Gloessl, J.; Weterings, K.; Pabst, M.; Steinkellner, H.
Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure
Plant Biotechnol. J.
6
392-402
2008
Nicotiana benthamiana
brenda
Zhang, Y.; Liu, S.; Liu, Y.; Wang, Z.; Wang, X.; Yan, Q.
Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation
Fertil. Steril.
91
908-914
2009
Homo sapiens (Q11130), Homo sapiens
brenda
Both, P.; Sobczak, L.; Breton, C.; Hann, S.; Noebauer, K.; Paschinger, K.; Kozmon, S.; Mucha, J.; Wilson, I.B.
Distantly related plant and nematode core alpha1,3-fucosyltransferases display similar trends in structure-function relationships
Glycobiology
21
1401-1415
2011
Caenorhabditis elegans (G5EDR5), Caenorhabditis elegans, Arabidopsis thaliana (Q9C8W3), Arabidopsis thaliana
brenda
Liu, T.W.; Kaji, H.; Togayachi, A.; Ito, H.; Sato, T.; Narimatsu, H.
A chemoenzymatic approach toward the identification of fucosylated glycoproteins and mapping of N-glycan sites
Glycobiology
22
630-637
2012
Homo sapiens
brenda
Koetzler, M.P.; Blank, S.; Behnken, H.N.; Alpers, D.; Bantleon, F.I.; Spillner, E.; Meyer, B.
Formation of the immunogenic alpha1,3-fucose epitope: elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A
Insect Biochem. Mol. Biol.
42
116-125
2012
Apis mellifera
brenda
Kurz, S.; King, J.G.; Dinglasan, R.R.; Paschinger, K.; Wilson, I.B.
The fucomic potential of mosquitoes: Fucosylated N-glycan epitopes and their cognate fucosyltransferases
Insect Biochem. Mol. Biol.
68
52-63
2016
Anopheles gambiae (Q7QBF7), Anopheles gambiae (Q7QF91), Anopheles gambiae
brenda
Yan, S.; Serna, S.; Reichardt, N.C.; Paschinger, K.; Wilson, I.B.
Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans
J. Biol. Chem.
288
21015-21028
2013
Caenorhabditis elegans
brenda
Kumar, A.; Torii, T.; Ishino, Y.; Muraoka, D.; Yoshimura, T.; Togayachi, A.; Narimatsu, H.; Ikenaka, K.; Hitoshi, S.
The Lewis X-related alpha1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations
J. Biol. Chem.
288
28859-28868
2013
Mus musculus
brenda
Geisler, C.; Mabashi-Asazuma, H.; Kuo, C.W.; Khoo, K.H.; Jarvis, D.L.
Engineering beta1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells
J. Biotechnol.
193
52-65
2015
Homo sapiens (Q11130)
brenda
Ohashi, H.; Ohashi, T.; Kajiura, H.; Misaki, R.; Kitamura, S.; Fujiyama, K.
Fucosyltransferases produce N-glycans containing core l-galactose
Biochem. Biophys. Res. Commun.
483
658-663
2017
Arabidopsis thaliana (Q9LJK1)
brenda
Mercx, S.; Smargiasso, N.; Chaumont, F.; De Pauw, E.; Boutry, M.; Navarre, C.
Inactivation of the beta(1,2)-xylosyltransferase and the alpha(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 cells by a Multiplex CRISPR/Cas9 strategy results in glycoproteins without plant-specific glycans
Front. Plant Sci.
8
403
2017
Nicotiana tabacum (A0A1S4AG82), Nicotiana tabacum (A0A1S4DHZ6), Nicotiana tabacum (D6RSA0)
brenda
Okada, T.; Ihara, H.; Ikeda, Y.
Characterization of MiFUT11 from Mangifera indica L. A functional core alpha1,3-fucosyltransferase potentially involved in the biosynthesis of immunogenic carbohydrates in mango fruit
Phytochemistry
165
112050
2019
Mangifera indica (A0A5A4RK11)
brenda