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UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[integrin beta1]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[integrin beta1]
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + pyridylaminated acceptor substrate
?
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP-N-acetyl-D-glucosamine + biantennary N-glycan
?
-
the enzyme transfers a N-acetyl-D-glucosamine from UDP-N-acetyl-D-glucosamine to the biantennary oligosaccharide and produces triantennary N-glycans with a beta1,4-N-acetyl-D-glucosamine on the alpha1,3-Man arm
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
UDP + ?
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
isozyme GnT-IVb has about 30% activity of isozyme GnT-IVa
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2, LAMP-2 has 16 N-glycans which play crucial roles in cell adhesion to ECM and metastasis of cancer cells because N-glycans configure cell surface ligands of cancer cells for galectin-1, galectin-3, and selectins on extracellular matrix or the membranes of the counter cell
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
maximal activity requires the presence of both terminal beta-1,2-linked N-acetylglucosamine residues in the substrate
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
maximal activity requires the presence of both terminal beta-1,2-linked N-acetylglucosamine residues in the substrate
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
R represents the remainder of the N-oligosaccharide in the glycoprotein acceptor, the enzyme adds N-cetylglucosamine in beta-1,4-linkage to the alpha-1,3-linked mannosyl residues of the trimannosyl core of N-glycosyloligosaccharides
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVb might contribute to the basal GnT-IV activity in cells
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
the enzyme is involved in the branch formation of Asn-linked sugar chains
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
pyridylaminated sugar chain
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
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UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2, LAMP-2 has 16 N-glycans which play crucial roles in cell adhesion to ECM and metastasis of cancer cells because N-glycans configure cell surface ligands of cancer cells for galectin-1, galectin-3, and selectins on extracellular matrix or the membranes of the counter cell
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVb might contribute to the basal GnT-IV activity in cells
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
the enzyme is involved in the branch formation of Asn-linked sugar chains
-
-
?
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alpha-1,3-mannosyl-glycoprotein 4-beta-n-acetylglucosaminyltransferase deficiency
Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.
Carcinoma
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma.
Carcinoma, Hepatocellular
Determination of N-acetylglucosaminyltransferases III, IV and V in normal and hepatoma tissues of rats.
Choriocarcinoma
High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Choriocarcinoma
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Choriocarcinoma
Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma.
Choriocarcinoma
Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Diabetes Mellitus, Type 2
Targeted genetic inactivation of N-acetylglucosaminyltransferase-IVa impairs insulin secretion from pancreatic beta cells and evokes type 2 diabetes.
Diabetes Mellitus, Type 2
The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of Type 2 Diabetes patients.
Hydatidiform Mole, Invasive
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Lung Neoplasms
Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens.
Neoplasm Metastasis
N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
Neoplasms
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
Neoplasms
Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics.
Neoplasms
Identification of hub genes and key pathways associated with the progression of gynecological cancer.
Neoplasms
Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.
Neoplasms
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Neoplasms
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Pancreatic Neoplasms
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
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0.532 - 3.35
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
1.04 - 6.94
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
0.971 - 5.72
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
3.19 - 10.5
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
3.4
pyridylaminated acceptor substrate
-
-
-
0.118 - 0.358
UDP-N-acetyl-D-glucosamine
8.3
UDP-N-acetylglucosamine
-
pyridylaminated acceptor substrate
0.532
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
3.35
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
1.04
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
6.94
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
0.971
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
5.72
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
3.19
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
10.5
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
0.118
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
0.242
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
0.341
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
0.358
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
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malfunction
-
isozyme GnT-IVb deficiency shows mild phenotypic alterations in hematopoietic cell populations and hemostasis, GnT-IVa/-IVb double deficiency completely abolishes GnT-IV activity that results in the disappearance of the GlcNAcbeta1-4 branch on the Manalpha1-3 arm
malfunction
aberrant glycosylation of the cell surface is associated with the malignant transformation of normal cells. Tumor-cell-surface glycans are closely associated with tumor-cell migration, adhesion, and metastasis4, profiling of specific cell surface N-glycans in hepatocellular carcinoma with clinical tissues (88 tumor and adjacent normal tissues) and the corresponding serum samples of hepatocellular carcinoma patients, overview. The level of core-alpha-1,6-fucosylated triantennary glycan (NA3Fb) increases both on the cell surface and in the serum samples of hepatocellular carcinoma patients, and mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which is related to the synthesis of the NA3Fb, is substantially increased in hepatocellular carcinoma tissues. Knockdown of GnT-IVa leads to a decreased level of NA3Fb and decreased ability of invasion and migration in HCC cells. The high expression of GnT-IVa is the cause of the abnormal increase of NA3Fb on the HCC cell surface, which regulates cell migration
malfunction
GnT-IVa overexpression increases cell adhesion, migration and invasion abilities of Jar cells. GnT-IVa overexpression increases cellular interaction with ECM as demonstrated by the relative adhesion rates of mock cells and Jar-GnT4a cells on fibronectin, collagen type I and collagen type IV. GnT-IVa knockdown in choriocarcinoma cells suppresses migration and invasion and decreases cellular adhesion to extracellular matrix
metabolism
-
N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V
metabolism
-
N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V
physiological function
-
the enzyme acts in migration and metastasis of mouse hepatocarcinoma cells through altering the glycosylation of CD147
physiological function
the enzyme is involved in synthesis of tetra-antennary N-linked glycans. Cell surface glycans play an important role in intercellular and intracellular processes, including cell adhesion and development, cell recognition, and cancer development and metastasis. Changes in cell surface glycosylation modulate cellular activity
physiological function
N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of beta1,4GlcNAc branches on the mannose core of N-glycans. beta1,4GlcNAc branches on human chorionic gonadotropin (hCG) are detected in GTN but not in normal pregnancy or hydatidiform mole. N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. Identification of target proteins for GnT-IVa glycosylation which contribute to the malignancy of choriocarcinoma, overview. GnT-IVa overexpression increases highly branched N-glycans on integrin beta1. Highly branched N-glycans resulting from the action of GnT-IVa are strongly detected in invasive mole and choriocarcinoma, in proportion to the GnT-IVa protein expression. GnT-IVa may play an important role in accelerating the malignancy of choriocarcinoma through addition of beta1,4GlcNAc branches to the N-glycans on some proteins
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MGT4A_BOVIN
535
1
61618
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_CHICK
535
1
61566
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_HUMAN
535
1
61544
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_MACFA
535
1
61574
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_MOUSE
535
1
61480
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_PONAB
535
1
61525
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_RAT
526
1
60590
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_XENLA
536
1
62020
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4A_XENTR
536
1
62007
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4B_DANRE
547
1
62991
Swiss-Prot
Secretory Pathway (Reliability: 1)
MGT4B_HUMAN
548
1
63198
Swiss-Prot
Secretory Pathway (Reliability: 1)
MGT4B_MOUSE
548
1
63302
Swiss-Prot
Secretory Pathway (Reliability: 1)
MGT4C_DANRE
454
1
52254
Swiss-Prot
Secretory Pathway (Reliability: 2)
MGT4C_HUMAN
478
1
56061
Swiss-Prot
Secretory Pathway (Reliability: 5)
MGT4C_MACFA
478
1
56089
Swiss-Prot
Secretory Pathway (Reliability: 5)
MGT4C_MOUSE
478
1
56250
Swiss-Prot
Mitochondrion (Reliability: 5)
MGT4C_PIG
478
1
56312
Swiss-Prot
Secretory Pathway (Reliability: 5)
D8LCU4_ECTSI
430
0
45913
TrEMBL
other Location (Reliability: 1)
A0A6J8E7J4_MYTCO
454
1
52855
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8E0W7_MYTCO
534
1
61841
TrEMBL
Secretory Pathway (Reliability: 3)
A0A6J8C9L3_MYTCO
574
1
66586
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8BBS0_MYTCO
223
0
26165
TrEMBL
other Location (Reliability: 3)
C0H9Y9_SALSA
533
1
61390
TrEMBL
Secretory Pathway (Reliability: 2)
B9EN49_SALSA
73
1
8516
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8BDP2_MYTCO
326
0
38240
TrEMBL
other Location (Reliability: 2)
A0A6J8E6V4_MYTCO
811
1
95247
TrEMBL
other Location (Reliability: 5)
A0A6J8BCQ9_MYTCO
500
1
58440
TrEMBL
other Location (Reliability: 5)
A0A6J8B048_MYTCO
339
1
39968
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8B6HAM0_MYTGA
548
1
63847
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8E900_MYTCO
552
1
64061
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J8B231_MYTCO
513
1
59364
TrEMBL
Secretory Pathway (Reliability: 5)
A0A7R8CIV3_LEPSM
105
0
12019
TrEMBL
other Location (Reliability: 2)
A0A6J8BFE8_MYTCO
484
1
56894
TrEMBL
Secretory Pathway (Reliability: 1)
A2QZU3_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
383
2
44352
TrEMBL
Mitochondrion (Reliability: 2)
A0A7R8CBB4_LEPSM
288
1
34207
TrEMBL
Secretory Pathway (Reliability: 3)
A0A7R8CG85_LEPSM
229
0
26778
TrEMBL
Mitochondrion (Reliability: 3)
A0A6J8BBR7_MYTCO
477
1
55986
TrEMBL
Secretory Pathway (Reliability: 1)
A0A812D6A8_SEPPH
1042
14
119149
TrEMBL
other Location (Reliability: 5)
A0A7R8GZE5_LEPSM
724
4
82056
TrEMBL
Secretory Pathway (Reliability: 3)
A0A7R8HE35_LEPSM
230
0
27501
TrEMBL
other Location (Reliability: 2)
A0A6J8E5J6_MYTCO
461
1
53901
TrEMBL
Secretory Pathway (Reliability: 4)
A0A7R8HDD6_LEPSM
309
1
36561
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8DYR5_MYTCO
477
1
55903
TrEMBL
Secretory Pathway (Reliability: 3)
A2Q921_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
433
3
49975
TrEMBL
Secretory Pathway (Reliability: 4)
A0A061HX10_CRIGR
454
0
51125
TrEMBL
other Location (Reliability: 1)
A0A6J8BDA4_MYTCO
369
1
43668
TrEMBL
Secretory Pathway (Reliability: 5)
A0A7R8CN15_LEPSM
493
1
56903
TrEMBL
Secretory Pathway (Reliability: 1)
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Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Gallus gallus
brenda
Gleeson, P.A.; Schachter, H.
Control of glycoprotein synthesis
J. Biol. Chem.
258
6162-6173
1983
Gallus gallus
brenda
Taniguchi, N.; Nishikawa, A.; Fujii, S.; Gu, J.
Glycosyltransferase assays using pyridylaminated acceptors: N-acetylglucosaminyltransferase III, IV, and V
Methods Enzymol.
179
397-408
1989
Rattus norvegicus
brenda
Oguri, S.; Minowa, M.T.; Ihara, Y.; Taniguchi, N.; Ikenaga, H.; Takeuchi, M.
Purification and characterization of UDP-N-acetylglucosamine: alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase-IV) from bovine small intestine
J. Biol. Chem.
272
22721-22727
1997
Bos taurus (O77836)
brenda
Zhu, T.Y.; Chen, H.L.; Gu, J.X.; Zhang, Y.F.; Zhang, Y.K.; Zhang, R.A.
Changes in N-acetylglucosaminyltransferase III, IV, and V in renal cell carcinoma
J. Cancer Res. Clin. Oncol.
123
296-299
1997
Homo sapiens
brenda
Minowa, M.T.; Oguri, S.; Yoshida, A.; Hara, T.; Iwamatsu, A.; Ikenaga, H.; Takeuchi, M.
cDNA cloning and expression of bovine UDP-N-acetylglucosamine: alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase IV
J. Biol. Chem.
273
11556-11562
1998
Bos taurus (O77836), Bos taurus
brenda
Yoshida, A.; Minowa, M.T.; Takamatsu, S.; Hara, T.; Ikenaga, H.; Takeuchi, M.
A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment
Glycoconjugate J.
15
1115-1123
1998
Homo sapiens (Q9UQ53), Homo sapiens
brenda
Nan, B.C.; Shao, D.M.; Chen, H.L.; Huang, Y.; Gu, J.X.; Zhang, Y.B.; Wu, Z.G.
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma
Glycoconjugate J.
15
1033-1037
1998
Homo sapiens
brenda
Yoshida, A.; Minowa, M.T.; Takamatsu, S.; Hara, T.; Oguri, S.; Ikenaga, H.; Takeuchi, M.
Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase
Glycobiology
9
303-310
1999
Homo sapiens (Q9UM21), Homo sapiens
brenda
Takamatsu, S.; Oguri, S.; Minowa, M.T.; Yoshida, A.; Nakamura, K.; Takeuchi, M.; Kobata, A.
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain
Cancer Res.
59
3949-3953
1999
Homo sapiens
brenda
Takamatsu, S.; Inoue, N.; Katsumata, T.; Nakamura, K.; Fujibayashi, Y.; Takeuchi, M.
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures
Biochemistry
44
6343-6349
2005
Homo sapiens
brenda
Jin, X.L.; Liu, H.B.; Zhang, Y.; Wang, B.S.; Chen, H.L.
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma
Glycoconj. J.
20
399-406
2004
Homo sapiens
brenda
Takamatsu, S.; Katsumata, T.; Inoue, N.; Watanabe, T.; Fujibayashi, Y.; Takeuchi, M.
Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3
Glycoconj. J.
20
473-481
2004
Homo sapiens
brenda
Ide, Y.; Miyoshi, E.; Nakagawa, T.; Gu, J.; Tanemura, M.; Nishida, T.; Ito, T.; Yamamoto, H.; Kozutsumi, Y.; Taniguchi, N.
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer
Biochem. Biophys. Res. Commun.
341
478-482
2006
Homo sapiens (Q9UM21), Homo sapiens (Q9UQ53)
brenda
Oguri, S.; Yoshida, A.; Minowa, M.T.; Takeuchi, M.
Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes
Glycoconj. J.
23
473-480
2006
Homo sapiens
brenda
Kim, N.Y.; Kim, H.G.; Kim, Y.H.; Chung, I.S.; Yang, J.M.
Expression and characterization of human N-acetylglucosaminyltransferases and alpha2,3-sialyltransferase in insect cells for in vitro glycosylation of recombinant erythropoietin
J. Microbiol. Biotechnol.
18
383-391
2008
Homo sapiens
brenda
Kudo, T.; Nakagawa, H.; Takahashi, M.; Hamaguchi, J.; Kamiyama, N.; Yokoo, H.; Nakanishi, K.; Nakagawa, T.; Kamiyama, T.; Deguchi, K.; Nishimura, S.; Todo, S.
N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma
Mol. Cancer
6
32
2007
Homo sapiens (Q9UM21), Homo sapiens (Q9UQ53), Homo sapiens
brenda
Takamatsu, S.; Antonopoulos, A.; Ohtsubo, K.; Ditto, D.; Chiba, Y.; Le, D.T.; Morris, H.R.; Haslam, S.M.; Dell, A.; Marth, J.D.; Taniguchi, N.
Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice
Glycobiology
20
485-497
2010
Mus musculus
brenda
Fan, J.; Wang, S.; Yu, S.; He, J.; Zheng, W.; Zhang, J.
N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147
Glycoconj. J.
29
323-334
2012
Mus musculus
brenda
Nagels, B.; Van Damme, E.J.; Pabst, M.; Callewaert, N.; Weterings, K.
Production of complex multiantennary N-glycans in Nicotiana benthamiana plants
Plant Physiol.
155
1103-1112
2011
Homo sapiens
brenda
Ohtsubo, K.
Biological significance of N-acetylglucosaminyltransferase-IV-mediated protein glycosylation on the homeostasis of cellular physiological functions
Trends Glycosci. Glycotechnol.
23
103-105
2011
Bos taurus, Homo sapiens
-
brenda
Nie, H.; Liu, X.; Zhang, Y.; Li, T.; Zhan, C.; Huo, W.; He, A.; Yao, Y.; Jin, Y.; Qu, Y.; Sun, X.L.; Li, Y.
Specific N-glycans of hepatocellular carcinoma cell surface and the abnormal increase of core-alpha-1,6-fucosylated triantennary Glycan via N-acetylglucosaminyltransferases-IVa regulation
Sci. Rep.
5
16007
2015
Homo sapiens (Q9UM21), Homo sapiens
brenda
Nishino, K.; Yamamoto, E.; Niimi, K.; Sekiya, Y.; Yamashita, Y.; Kikkawa, F.
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma
Oncol. Rep.
38
440-448
2017
Homo sapiens (Q9UM21), Homo sapiens
brenda