Disease on EC 2.3.1.B46 - 1-acylglycerophosphatidylinositol O-acyltransferase
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1-acylglycerophosphatidylinositol o-acyltransferase deficiency
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability.
1-acylglycerophosphatidylinositol o-acyltransferase deficiency
Loss of hepatic Mboat7 leads to liver fibrosis.
1-acylglycerophosphatidylinositol o-acyltransferase deficiency
LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice.
Adenocarcinoma
The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Carcinogenesis
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Carcinoma, Hepatocellular
Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma.
Carcinoma, Hepatocellular
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals.
Carcinoma, Hepatocellular
The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Cardiovascular Diseases
Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Cholangitis, Sclerosing
The MBOAT7 rs641738 variant in primary sclerosing cholangitis: A novel biomarker for prognostication.
Cholangitis, Sclerosing
The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Epilepsy
Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features.
Fatty Liver
A Novel Phosphoinositide-3-kinase Adapter Protein 1 Gene Missense Mutation in Familial Cirrhosis.
Fatty Liver
Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children.
Fatty Liver
Combined use of genetic polymorphisms and elastographic techniques in NAFLD. Fact or fiction?
Fatty Liver
Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets.
Fatty Liver
Hepatic Deletion of Mboat7 (Lpiat1) Causes Activation of SREBP-1c and Fatty Liver.
Fatty Liver
Hepatic deletion of Mboat7 (Lpiat1) causes activation of SREBP-1c and fatty liver.
Fatty Liver
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability.
Fatty Liver
LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol.
Fatty Liver
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
Fatty Liver
Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Fatty Liver
Racial differences in prevalence and severity of non-alcoholic fatty liver disease.
Fatty Liver
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis.
Fatty Liver
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.
Fatty Liver
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.
Fatty Liver
[Secondary causes of fatty liver disease - an update on pathogenesis, diagnosis and treatment strategies].
Hepatitis B, Chronic
Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients.
Hepatitis B, Chronic
The MBOAT7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B.
Hepatitis C
Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis.
Hepatitis C
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.
Hepatitis C, Chronic
Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients.
Hepatitis C, Chronic
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.
Insulin Resistance
Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children.
Insulin Resistance
Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum.
Insulin Resistance
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.
Intellectual Disability
Expanding the phenotypic spectrum of MBOAT7-related intellectual disability.
Intellectual Disability
Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families.
Intellectual Disability
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability.
Intellectual Disability
Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features.
Intellectual Disability
Phenotypic Characterization of Intellectual Disability Caused by MBOAT7 Mutation in Two Consanguineous Pakistani Families.
Liver Cirrhosis
Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children.
Liver Cirrhosis
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.
Liver Cirrhosis
The impact of genetic risk on liver fibrosis in non-alcoholic fatty liver disease as assessed by magnetic resonance elastography.
Liver Cirrhosis
The Membrane-bound O-Acyltransferase7 rs641738 Variant in Pediatric Nonalcoholic Fatty Liver Disease.
Liver Cirrhosis, Alcoholic
A two gene-based risk score predicts alcoholic cirrhosis development in males with at-risk alcohol consumption.
Liver Cirrhosis, Alcoholic
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.
Liver Cirrhosis, Alcoholic
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis.
Liver Diseases
A Novel Phosphoinositide-3-kinase Adapter Protein 1 Gene Missense Mutation in Familial Cirrhosis.
Liver Diseases
Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-confirmed Nonalcoholic Fatty Liver Disease.
Liver Diseases
Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study.
Liver Diseases
Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.
Liver Diseases
Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients.
Liver Diseases
Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets.
Liver Diseases
Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan.
Liver Diseases
Hepatic Deletion of Mboat7 (Lpiat1) Causes Activation of SREBP-1c and Fatty Liver.
Liver Diseases
Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis.
Liver Diseases
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability.
Liver Diseases
Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma.
Liver Diseases
Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease.
Liver Diseases
LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol.
Liver Diseases
Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility.
Liver Diseases
Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Liver Diseases
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.
Liver Diseases
Risk of chemotherapy-associated liver injury (CALI) in PNPLA3 p.148M allele carriers: Preliminary results of a transient elastography-based study.
Liver Diseases
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis.
Liver Diseases
The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Liver Diseases
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.
Liver Diseases
[Secondary causes of fatty liver disease - an update on pathogenesis, diagnosis and treatment strategies].
Liver Diseases, Alcoholic
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.
Lung Neoplasms
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Megalencephaly
A patient with novel MBOAT7 variant: The cerebellar atrophy is progressive and displays a peculiar neurometabolic profile.
Metabolic Syndrome
Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Metabolic Syndrome
[Secondary causes of fatty liver disease - an update on pathogenesis, diagnosis and treatment strategies].
Microcephaly
A patient with novel MBOAT7 variant: The cerebellar atrophy is progressive and displays a peculiar neurometabolic profile.
Muscle Hypotonia
Expanding the phenotypic spectrum of MBOAT7-related intellectual disability.
Neoplasms
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma.
Neoplasms
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Non-alcoholic Fatty Liver Disease
A Novel Phosphoinositide-3-kinase Adapter Protein 1 Gene Missense Mutation in Familial Cirrhosis.
Non-alcoholic Fatty Liver Disease
Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-confirmed Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children.
Non-alcoholic Fatty Liver Disease
Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study.
Non-alcoholic Fatty Liver Disease
Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.
Non-alcoholic Fatty Liver Disease
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.
Non-alcoholic Fatty Liver Disease
Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.
Non-alcoholic Fatty Liver Disease
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Epidemiology and risk-stratification of NAFLD-associated HCC.
Non-alcoholic Fatty Liver Disease
Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy.
Non-alcoholic Fatty Liver Disease
Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children.
Non-alcoholic Fatty Liver Disease
Genetic pathways in nonalcoholic fatty liver disease: Insights from systems biology.
Non-alcoholic Fatty Liver Disease
Genetics of Nonalcoholic Fatty Liver Disease: a 2018 Update.
Non-alcoholic Fatty Liver Disease
Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol.
Non-alcoholic Fatty Liver Disease
MBOAT7 is anchored to endomembranes by six transmembrane domains.
Non-alcoholic Fatty Liver Disease
Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility.
Non-alcoholic Fatty Liver Disease
Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Non-alcoholic Fatty Liver Disease
NAFLD in children: new genes, new diagnostic modalities and new drugs.
Non-alcoholic Fatty Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD), But not Its Susceptibility Gene Variants, Influences the Decrease of Kidney Function in Overweight/Obese Children.
Non-alcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease or metabolic dysfunction-associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches.
Non-alcoholic Fatty Liver Disease
Novel Insights into the Genetic Landscape of Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery.
Non-alcoholic Fatty Liver Disease
Predictors for incidence and remission of nonalcoholic fatty liver disease in obese children and adolescents.
Non-alcoholic Fatty Liver Disease
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis.
Non-alcoholic Fatty Liver Disease
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.
Non-alcoholic Fatty Liver Disease
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.
Non-alcoholic Fatty Liver Disease
The Membrane-bound O-Acyltransferase7 rs641738 Variant in Pediatric Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.
Non-alcoholic Fatty Liver Disease
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis.
Non-alcoholic Fatty Liver Disease
Update on NAFLD genetics: from new variants to the clinic.
Obesity
Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children.
Obesity
Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity.
Overweight
Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children.
Pediatric Obesity
The Membrane-bound O-Acyltransferase7 rs641738 Variant in Pediatric Nonalcoholic Fatty Liver Disease.
Renal Insufficiency, Chronic
Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-confirmed Nonalcoholic Fatty Liver Disease.
Seizures
A patient with novel MBOAT7 variant: The cerebellar atrophy is progressive and displays a peculiar neurometabolic profile.
Seizures
Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families.
Seizures
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability.
Stomach Neoplasms
Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.
Venous Thromboembolism
Nonalcoholic fatty liver disease or metabolic dysfunction-associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches.
Virus Diseases
Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis.
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