BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB CommentsBoth free and glycosidically bound N-acetyl- and N-glycolyl- neuraminates can act as O-acetyl acceptors.
The enzyme appears in viruses and cellular organisms
Synonyms
sialate o-acetyltransferase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyltransferase, N-acetylneuraminate 4-O-
-
-
-
-
sialate O-acetyltransferase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase
Both free and glycosidically bound N-acetyl- and N-glycolyl- neuraminates can act as O-acetyl acceptors.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + ganglioside 9-O-acetyl-GD3
CoA + ganglioside 4,9-O-diacetyl-GD3
-
110% of the acitivity with ganglioside GD3
-
-
?
acetyl-CoA + ganglioside GD1a
CoA + 4-O-acetylganglioside GD1a
-
90% of the acitivity with ganglioside GD3
-
-
?
acetyl-CoA + ganglioside GD2
CoA + 4-O-acetylated ganglioside GD2
-
48% of the acitivity with ganglioside GD3
-
-
?
acetyl-CoA + ganglioside GD3
CoA + 4-O-acetylated ganglioside GD3
-
-
-
-
?
acetyl-CoA + ganglioside GQ1b
CoA + 4-O-acetylated ganglioside GQ1b
-
125% of the acitivity with ganglioside GD3
-
-
?
acetyl-CoA + ganglioside GT1b
CoA + 4-O-acetylated ganglioside GT1b
-
80% of the acitivity with ganglioside GD3
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyltransferase is specific for the hydroxyl group at C-4 of the pyranose ring of neuraminic acid
-
r
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-4-O-acetylneuraminate
-
the 4-O-acetyl-group seems to be stable, as no conversion of this sialic acid to other O-acetylated species is observed
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3',5'-ADP
-
80% inhibition at 1 mM
3'-dephospho-coenzyme A
-
50% inhibition at 0.022 mM
4,4-diisothiocyanatostilbene-2,2-disulfonate
-
-
ATP
-
20% inhibition at 1 mM
coenzyme A
-
50% inhibition at 0.013 mM
desulfo-coenzyme A
-
50% inhibition at 0.013 mM
IDP
-
30% inhibition at 1 mM
IMP
-
16% inhibition at 1 mM
ITP
-
58% inhibition at 1 mM
NADPH
-
18% inhibition at 1 mM
pyridoxal 5'-phosphate
-
75% inhibition at 1 mM
CoA
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
100% inhibition at 1 mM
p-chloromercuribenzoate
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00061 - 0.0321
acetyl-CoA
0.0012
ganglioside GD3
-
-
0.00061
acetyl-CoA
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0042
CoA
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
rapid method for measuring enzyme activity using ganglioside GD3
additional information
-
assay method
additional information
-
assay method
additional information
-
assay method
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6.7
-
in 70 mM potassium phosphate buffer and the presence of 90 mM KCl
7.5
-
assay at
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5.6
-
solubilized enzyme, presence of KCl and K2HPO4
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
30
-
-
30
-
solubilized enzyme, presence of KCl and K2HPO4
37
-
assay at
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
australian monotreme echidna
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
analysis of solubilisation by detergent CHAPS. Need for an unknown low molecular mass and heat-stable cofactor
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Schauer, R.
Sialic acids: metabolism of O-acetyl groups
Methods Enzymol.
138
611-626
1987
Equus asinus, Equus caballus, Tachyglossus aculeatus
brenda
Schauer, R.
Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse
Hoppe-Seyler's Z. Physiol. Chem.
351
595-602
1970
Equus caballus
brenda
Tiralongo, J.; Schmid, H.; Thun, R.; Iwersen, M.; Schauer, R.
Characterisation of the enzymatic 4-O-acetylation of sialic acids in microsomes from equine submandibular glands
Glycoconj. J.
17
849-858
2001
Equus caballus
brenda
Iwersen, M.; Vandamme-Feldhaus, V.; Schauer, R.
Enzymic 4-O-acetylation of N-acetylneuraminic acid in guinea-pig liver
Glycoconj. J.
15
895-904
1998
Cavia porcellus
brenda
Iwersen, M.; Dora, H.; Kohla, G.; Gasa, S.; Schauer, R.
Solubilisation and properties of the sialate-4-O-acetyltransferase from guinea pig liver
Biol. Chem.
384
1035-1047
2003
Cavia porcellus
brenda
Select items on the left to see more content.
html completed