Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.1.309 - [beta-tubulin]-L-lysine N-acetyltransferase

for references in articles please use BRENDA:EC2.3.1.309
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme acetylates L-lysine at position 252 of beta-tubulin, which is located at the interface of alpha/beta-tubulin heterodimers and interacts with the phosphate group of the alpha-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258, N-terminal methionine Nalpha-acetyltransferase NatE. cf. EC 2.3.1.108, alpha-tubulin N-acetyltransferase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a [beta-tubulin]-L-lysine
=
+
a [beta-tubulin]-N6-acetyl-L-lysine
Synonyms
Naa50, Naa50/San, NatE, SAN, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + a [beta-tubulin]-L-lysine = CoA + a [beta-tubulin]-N6-acetyl-L-lysine
show the reaction diagram
-
-
-
-
Select items on the left to see more content.