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Disease on EC 2.3.1.28 - chloramphenicol O-acetyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis.
Adenocarcinoma
Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.
Promoter region of the human alpha 2A adrenergic receptor gene.
Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene.
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture.
Adenocarcinoma of Lung
Characterization of the promoter of human pulmonary surfactant protein B gene.
cis-acting elements involved in the regulation of mouse Clara cell-specific 10-kDa protein gene. In vitro and in vivo analysis.
Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor.
MDM2 suppresses p73 function without promoting p73 degradation.
SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.
Adenoviridae Infections
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Anemia
Localization of sequences responsible for trans-activation of the equine infectious anemia virus long terminal repeat.
Astrocytoma
Constitutive expression of human immunodeficiency virus (HIV) nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity.
Effect of eukaryotic initiation factor 4F on AUG selection in a bicistronic mRNA.
Identification and characterization of the promoter for the cytotactin gene.
Bacterial Infections
In vivo expression of the beta-glucoside (bgl) operon of Escherichia coli occurs in mouse liver.
Brain Ischemia
Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation.
Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation.
Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia.
Breast Neoplasms
Bifunctional gonadotropin-releasing hormone antagonist-progesterone analogs with increased efficacy and duration of action.
Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.
Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.
Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors.
Establishment of in vitro test system for the evaluation of the estrogenic activities of natural products.
Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.
Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells.
Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays.
Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells.
Regulation by estrogen through the 5'-flanking region of the mouse calbindin-D28k gene.
Regulation by estrogen through the 5'-flanking region of the transforming growth factor alpha gene.
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators.
The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.
The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.
Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor.
Bronchitis
cis-acting sequences required for coronavirus infectious bronchitis virus defective-RNA replication and packaging.
Expression of reporter genes from the defective RNA CD-61 of the coronavirus infectious bronchitis virus.
Burkitt Lymphoma
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression.
Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.
Carcinogenesis
Human immunodeficiency virus type 1 tat gene enhances human papillomavirus early gene expression.
Trans-activation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat.
[Regulation mechanism of specific expression of tumor marker gene during carcinogenesis]
Carcinoma
Cis-acting elements required for expression of the nonspecific cross-reacting antigen gene in colorectal carcinoma.
Comparative functional analysis of the various lentivirus long terminal repeats in human colon carcinoma cell line (SW480 cells) and feline renal cell line (CRFK cells).
Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene.
Enhancer function of a 53-bp repetitive element in the 5' flanking region of the human neutrophil elastase gene.
Evolutionary distinct mechanisms regulate apolipoprotein A-I gene expression: differences between avian and mammalian apoA-I gene transcription control regions.
Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions.
Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene.
Hepatocyte nuclear factor 3 is a major determinant of CYP2C6 promoter activity in hepatoma cells.
Identification of multiple regulatory elements of human L-histidine decarboxylase gene.
Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.
Prolonged transgene expression in rodent lung cells.
The upstream region of the mouse N-myc gene: identification of an enhancer element that functions preferentially in neuroblastoma IMR32 cells.
Transcriptional activation of stress genes and cytotoxicity in human liver carcinoma cells (HepG2) exposed to 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene.
Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent.
Carcinoma, Ductal
Prolactin acts on the extreme 5' portion of MMTV LTR involving a mammary cell-specific enhancer.
Carcinoma, Embryonal
Analysis of the binding proteins and activity of the long terminal repeat of Moloney murine leukemia virus during differentiation of mouse embryonal carcinoma cells.
AP-1 and Krox-24 transcription factors activate the neurofilament light gene promoter in P19 embryonal carcinoma cells.
De novo methylation of transfected CAT gene plasmid constructs in F9 mouse embryonal carcinoma cells.
Enhancement of reporter gene de novo methylation by DNA fragments from the alpha-fetoprotein control region.
Retinoic acid-dependent transactivation of major histocompatibility complex class I promoters by the nuclear hormone receptor H-2RIIBP in undifferentiated embryonal carcinoma cells.
Transcriptional regulation of the int-2 gene in embryonal carcinoma cells.
Carcinoma, Hepatocellular
A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter.
A hormone response element upstream from the human alcohol dehydrogenase gene ADH2 consists of three tandem glucocorticoid receptor binding sites.
A liver-specific enhancer in the core promoter region of human hepatitis B virus.
A possible mechanism of inverse developmental regulation of alpha-fetoprotein and albumin genes. Studies with epidermal growth factor and phorbol ester.
A ubiquitous enhancer shared by two promoters in the human aldolase A gene.
Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells.
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice.
ATF-like element contributes to hepatic activation of human angiotensinogen promoter.
Beneficial effects of a novel thyromimetic on lipoprotein metabolism.
Beta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitro.
Cell-specific enhancer activity in a far upstream region of the human alpha-fetoprotein gene.
Cell-specific expression of mouse albumin promoter. Evidence for cell-specific DNA elements within the proximal promoter region and cis-acting DNA elements upstream of -160.
Characterization of hamster CYP1A1 gene: inducible expression and negative regulation.
Characterization of the chicken fatty acid synthase gene 5' part and promoter region.
Characterization of the promoter region of the human MDR3 P-glycoprotein gene.
cis-acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue-specific activators and extinguisher.
Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene.
Constitutive and NF-kappa B-like proteins in the regulation of the serum amyloid A gene by interleukin 1.
Constitutive expression of murine complement factor B gene is regulated by the interaction of its upstream promoter with hepatocyte nuclear factor 4.
Evolutionary distinct mechanisms regulate apolipoprotein A-I gene expression: differences between avian and mammalian apoA-I gene transcription control regions.
Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures.
Gene structure of mouse Cyp3a11: evidence for an enhancer element within its 5' flanking sequences.
Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene.
Glucocorticoid and estrogen regulation of a rat T-kininogen gene.
Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: receptor binding within intron I.
Heavy metal-mediated activation of the rat Cu/Zn superoxide dismutase gene via a metal-responsive element.
Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1.
Hepatocyte nuclear factor 3 is a major determinant of CYP2C6 promoter activity in hepatoma cells.
Hormonal discrimination among transcription start sites of aspartate aminotransferase.
Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation.
Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays.
Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein.
Identification of cell type-dependent enhancer core element located in the 3'-downstream region of the human angiotensinogen gene.
Identification of multiple regulatory elements on the human cytochrome P450IA1 gene.
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
Inhibition by insulin of protein kinase A-induced transcription of the phosphoenolpyruvate carboxykinase gene. Mediation by the activation domain of cAMP response element-binding protein (CREB) and factors bound to the TATA box.
Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences.
Interaction of interferon-alpha with interleukin-1 beta or tumor necrosis factor-alpha on hepatitis B virus enhancer activity.
Introduction of the glucocorticoid binding sequences into the expression vector p delta SVE-CAT and its effect on the CAT gene expression in mammalian cells.
Isolation and analysis of inducibility of the rat N-methylpurine-DNA glycosylase promoter.
Location and characterization of multiple glucocorticoid-responsive elements in the rat serine dehydratase gene.
Molecular cloning and analysis of the rat kallikrein-binding protein gene.
Molecular toxicology of peroxisome proliferators.
Oligo-3-hydroxybutyrates as potential carriers for drug delivery.
Organization of the 5' end of the rat gamma-glutamyl transpeptidase gene: structure of a promoter active in the kidney.
Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE).
Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro.
Rat pyruvate kinase M gene. Its complete structure and characterization of the 5'-flanking region.
Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer.
Regulation of the rat alpha-fetoprotein gene expression in liver. Both the promoter region and an enhancer element are liver-specific and negatively modulated by dexamethasone.
S-adenosylmethionine decarboxylase gene expression in rat hepatoma cells: regulation by insulin and by inhibition of protein synthesis.
Selection of promoters for gene transfer into fish.
Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site.
Structural and functional analysis of the rat testis-specific histone H1t gene.
Structure of the rainbow trout metallothionein B gene and characterization of its metal-responsive region.
Suppression of the human erythropoietin gene expression by the TR2 orphan receptor, a member of the steroid receptor superfamily.
Targeting of hexokinase 1 to liver and hepatoma mitochondria.
The CCAAT/enhancer-binding protein trans-activates the human cholesteryl ester transfer protein gene promoter.
The enhancer sequence of human hepatitis B virus can enhance the activity of its surface gene promoter.
The hepatitis B virus core promoter is strongly activated by the liver nuclear receptor fetoprotein transcription factor or by ectopically expressed steroidogenic factor 1.
The mechanism of the bidirectional regulation of the rat alpha-fetoprotein gene by glucocorticoid hormone.
The rat albumin gene promoter is appropriately regulated in transient but not in stable transfections.
The rat and human hemopexin genes contain an identical interleukin-6 response element that is not a target of CAAT enhancer-binding protein isoforms.
The Y-box motif mediates redox-dependent transcriptional activation in mouse cells.
Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents.
Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng.
Transcriptional regulation of alpha-fetoprotein expression by dexamethasone in human hepatoma cells.
Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene.
Transfection of hepatic genes into adult rat hepatocytes in primary culture and their tissue-specific expression.
Use of electroporation to introduce biologically active foreign genes into primary rat hepatocytes.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.
Carcinoma, Squamous Cell
Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.
Carcinosarcoma
[Cancer gene therapy by direct intratumoral injection: gene expression and intratumoral pharmacokinetics of plasmid DNA]
Choriocarcinoma
Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.
Different levels of ovine interferon-tau gene expressions are regulated through the short promoter region including Ets-2 binding site.
DNA sequences involved in the transcriptional activation of a human placental lactogen gene.
Identification and characterization of cis-acting regulatory elements for the expression of the human aromatase cytochrome P-450 gene.
Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome P450 gene (CYP19).
Identification of a promoter region in the CG beta gene cluster.
Interleukin-6 stimulates placental lactogen expression by human trophoblast cells.
Molecular cloning and characterization of the cyclic AMP-responsive ovine CYP11A1 (cholesterol side-chain cleavage) gene promoter: DNase 1 protection of conserved consensus elements.
Progesterone regulates HLA-G gene expression through a novel progesterone response element.
Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3.
Retinoic acid and thyroid hormone regulate placental lactogen expression in human trophoblast cells.
The upstream promoter of the human LDL receptor gene does not contain a cyclic AMP response element.
trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene.
Transcriptional regulation of the human aromatase cytochrome P450 gene expression in human placental cells.
Classical Swine Fever
A recombinant classical swine fever virus stably expresses a marker gene.
Cockayne Syndrome
Transient expression of a plasmid gene, a tool to study DNA repair in human cells: defect of DNA repair in Cockayne syndrome; one thymine cyclobutane dimer is sufficient to block transcription.
Coinfection
In vivo and in vitro analysis of electrical activity-dependent expression of muscle acetylcholine receptor genes using adenovirus.
Molecular interactions of cytomegalovirus and the human and simian immunodeficiency viruses.
Colonic Neoplasms
Demonstration of promoter activity and alternative splicing in the region 5' to exon 1 of the APC gene.
Colorectal Neoplasms
Cis-acting elements required for expression of the nonspecific cross-reacting antigen gene in colorectal carcinoma.
Molecular cloning and structural characterization of the functional human thymosin beta4 gene.
Cystic Fibrosis
Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.
Dental Plaque
Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate.
Diphtheria
Expression of DNA Coding for Diphtheria Toxin Chain A Is Toxic to Plant Cells.
Pollen-specific expression of the Arabidopsis thaliana alpha 1-tubulin promoter assayed by beta-glucuronidase, chloramphenicol acetyltransferase and diphtheria toxin reporter genes.
Distemper
'Rescue' of mini-genomic constructs and viruses by combinations of morbillivirus N, P and L proteins.
Endometrial Neoplasms
Estrogen response module of the mouse lactoferrin gene contains overlapping chicken ovalbumin upstream promoter transcription factor and estrogen receptor-binding elements.
Involvement of mutations in the DPC4 promoter in endometrial carcinoma development.
Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element.
Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary.
Promoter-specific activation of mouse lactoferrin gene by epidermal growth factor involves two adjacent regulatory elements.
Enzootic Bovine Leukosis
Activation of enhancer sequences in type II human T-cell leukemia virus and bovine leukemia virus long terminal repeats by virus-associated trans-acting regulatory factors.
The bovine leukemia virus X region encodes a trans-activator of its long terminal repeat.
Equine Infectious Anemia
Localization of sequences responsible for trans-activation of the equine infectious anemia virus long terminal repeat.
Erythema
Evaluation of sunscreens with various sun protection factors in a new transgenic mouse model of cutaneous photoaging that measures elastin promoter activation.
Fibrosarcoma
Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.
Identification and characterization of the promoter for the cytotactin gene.
Foot-and-Mouth Disease
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Replication-competent foot-and-mouth disease virus RNAs lacking capsid coding sequences.
Fowlpox
Regulation of foreign gene in fowlpox virus by a vaccinia virus promoter.
Glioma
Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice.
Cell type-specific regulation of CREB gene expression: mutational analysis of CREB promoter activity.
Ethanol uses cAMP-independent signal transduction mechanisms to activate proenkephalin promoter activity in rat C6 glioma cells.
Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene.
PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor.
Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB.
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Head and Neck Neoplasms
Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene.
Hemorrhagic Septicemia, Viral
Rescue of synthetic salmonid rhabdovirus minigenomes.
Hepatitis
Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.
Mouse hepatitis virus nucleocapsid protein as a translational effector of viral mRNAs.
Requirement of the 5'-end genomic sequence as an upstream cis-acting element for coronavirus subgenomic mRNA transcription.
Using a defective-interfering RNA system to express the HE protein of mouse hepatitis virus for studying viral pathogenesis.
Hepatitis B
A hybrid baculovirus-bacteriophage T7 transient expression system.
Defective and nondefective adenovirus vectors for expressing foreign genes in vitro and in vivo.
Direct introduction of genes into rats and expression of the genes.
Eukaryotic promoters drive gene expression in Escherichia coli.
Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner.
Hepatitis B virus C gene promoter is under negative regulation.
High expression of exogenous cDNAs directed by HIV-1 long terminal repeat in human cells constitutively producing HIV-1 tat and adenovirus E1A/E1B.
Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein.
Identification of a region within the human immunodeficiency virus type 1 long terminal repeat that is essential for transactivation by the hepatitis B virus gene X.
Protein Kinase Activity of the Insulin Receptor Is Essential for Insulin-Regulated Gene Expression.
Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.
Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.
trans-activation of viral enhancers by the hepatitis B virus X protein.
Hepatitis C
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Hepatitis, Chronic
Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.
Hepatoblastoma
A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha.
Coordinated induction of the c-jun gene with genes encoding quinone oxidoreductases in response to xenobiotics and antioxidants.
Identification of a human immunodeficiency virus type 1 TAR binding protein in human hepatoblastoma HepG2 cells that trans-activates HIV-1 LTR-directed gene expression.
Identification of promoter region of guinea pig liver transglutaminase gene.
Increase caused by interleukin-6 in promoter activity of guinea pig liver transglutaminase gene.
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.
Herpes Simplex
A bi-functional reporter plasmid for the simultaneous transient expression assay of two herpes simplex virus promoters.
A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation.
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene.
A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates.
Activating elements in the promoter region of the chicken beta-actin gene.
Activation of gene expression by human herpesvirus 6 is reporter gene-dependent.
Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1.
Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral transactivators and a phorbol ester.
Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4.
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.
An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.
An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness.
BOX DNA: a novel regulatory element related to embryonal carcinoma cell differentiation.
Comparative genomic analysis of the HNF-4alpha transcription factor gene.
Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors.
Differential activation of hybrid genes containing herpes simplex virus immediate-early or delayed-early promoters after superinfection of stable DNA-transfected cell lines.
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.
Ecdysterone regulatory elements function as both transcriptional activators and repressors.
Efficiency of introns from various origins in fish cells.
Electric field-mediated gene transfer (electroporation) into mouse Friend and human K562 erythroleukemic cells.
Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action.
Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection.
Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors.
Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.
Herpes simplex virus virion stimulatory protein mRNA leader contains sequence elements which increase both virus-induced transcription and mRNA stability.
High efficiency transient expression of eukaryotic genes: use of an HSV-1 immediate early promoter (ICP4).
Hormonal induction of transfected genes depends on DNA topology.
Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression.
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase.
Identification of a glucocorticoid-responsive element in Epstein-Barr virus.
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Identification of a promoter mapping within the reiterated sequences that flank the herpes simplex virus type 1 UL region.
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.
Identification of an estrogen-responsive element in the rat LH beta gene. DNA-estrogen receptor interactions and functional analysis.
Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2.
Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.
Liposome-mediated gene therapy using HSV-TK/ganciclovir under the control of human PSA promoter in prostate cancer cells.
Mapping of interacting domains between the nucleocapsid protein and the phosphoprotein of vesicular stomatitis virus by using a two-hybrid system.
Minimal transcriptional enhancer of simian virus 40 is a 74-base-pair sequence that has interacting domains.
Molecular characterization of a novel transcription factor that controls stromelysin expression.
Papillomavirus trans-activator protein E2 activates expression from the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2.
Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.
The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities.
The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.
The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.
Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene.
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation.
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus.
Virus-induced modification of the host cell is required for expression of the bacterial chloramphenicol acetyltransferase gene controlled by a late herpes simplex virus promoter (VP5).
Hypersensitivity
Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.
Infections
Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1.
Activation of gene expression by human herpesvirus 6 is reporter gene-dependent.
Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1.
Baculovirus interaction with nontarget organisms: a virus-borne reporter gene is not expressed in two mammalian cell lines.
Bc1-2 protects mice against fatal alphavirus encephalitis.
Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles.
Emergence of large plaque-producing clones of human immunodeficiency virus (HIV) in vitro.
Endothelial cell DNA transfer and expression using petri dish electroporation and the nonreplicating vaccinia virus/T7 RNA polymerase hybrid system.
Ex vivo monitoring of protein production in baculovirus-infected Trichoplusia ni larvae with a GFP-specific optical probe.
Expression of recombinant DNA introduced into Chlamydia trachomatis by electroporation.
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.
Herpes simplex virus type 1 tegument protein VP22 is capable of modulating the transcription of viral TK and gC genes via interaction with viral ICP0.
Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression.
Identification of upstream promoter elements mediating early transcription from the 35,000-molecular-weight protein gene of Autographa californica nuclear polyhedrosis virus.
Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
Inhibition of HIV-1 transcription by cyclopentenone prostaglandin A1 in Jurkat T lymphocytes.
Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.
Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4.
Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promoters.
NF-kappa B-binding proteins induced by HSV-1 infection of U937 cells are not involved in activation of human immunodeficiency virus.
Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase.
Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells.
Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV.
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.
Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines.
Regulation of the herpesvirus saimiri (HVS) delayed-early 110-kilodalton promoter by HVS immediate-early gene products and a homolog of the Epstein-Barr virus R trans activator.
Repetitive adenovirus administration to the parotid gland: role of immunological barriers and induction of oral tolerance.
Restriction of vaccinia virus replication in CHO cells occurs at the stage of viral intermediate protein synthesis.
Retrovirus-mediated gene transfer into mouse cerebellar primary culture and its application to the neural transplantation.
Role of the DR2 repeat array in the regulation of the ICP34.5 gene promoter of herpes simplex virus type 1 during productive infection.
Segment-specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step.
Substitution of murine transthyretin (prealbumin) regulatory sequences into the Moloney murine leukemia virus long terminal repeat yields infectious virus with altered biological properties.
The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.
Transactivating potential of the 3' open reading frame of murine mammary tumor virus.
Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Infertility
Isolation of chloramphenicol acetyltransferase from soil bacteria for sterility testing of products containing chloramphenicol.
Influenza, Human
Amplification, expression, and packaging of foreign gene by influenza virus.
An influenza A virus containing influenza B virus 5' and 3' noncoding regions on the neuraminidase gene is attenuated in mice.
Efficient formation of influenza virus-like particles: dependence on the expression levels of viral proteins.
Expression of a foreign protein by influenza A virus.
HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site.
In vivo analysis of the promoter structure of the influenza virus RNA genome using a transfection system with an engineered RNA.
Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs.
Influenza B viruses with site-specific mutations introduced into the HA gene.
Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses.
Influenza virus NS1 protein stimulates translation of the M1 protein.
Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.
Inhibition of influenza virus RNA polymerase by 5'-capped short RNA fragments.
Intranasal inoculation of a recombinant influenza virus containing exogenous nucleotides in the NS segment induces mucosal immune response against the exogenous gene product in mice.
Mutational analysis of influenza virus promoter elements in vivo.
Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication.
Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses.
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
RNA polymerase I-mediated expression of influenza viral RNA molecules.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Temporal control for translation of influenza virus mRNAs.
The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.
The polyadenylation signal of influenza virus RNA involves a stretch of uridines followed by the RNA duplex of the panhandle structure.
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis.
The RNA polymerase PB2 subunit is not required for replication of the influenza virus genome but is involved in capped mRNA synthesis.
Translational regulation of influenza virus mRNAs.
Insulinoma
Characterization of the promoter of the mouse prohormone convertase PC2 gene.
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
Two 3',5'-cyclic-adenosine monophosphate response elements in the promoter region of the human gastric inhibitory polypeptide gene.
Latent Infection
Herpes simplex virus type 1 tegument protein VP22 is capable of modulating the transcription of viral TK and gC genes via interaction with viral ICP0.
Leukemia
Analysis of the binding proteins and activity of the long terminal repeat of Moloney murine leukemia virus during differentiation of mouse embryonal carcinoma cells.
c-myc intron element-binding proteins are required for 1, 25-dihydroxyvitamin D3 regulation of c-myc during HL-60 cell differentiation and the involvement of HOXB4.
Cell-specific expression of mouse albumin promoter. Evidence for cell-specific DNA elements within the proximal promoter region and cis-acting DNA elements upstream of -160.
Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1.
Comparison of various expression plasmids for the induction of immune response by DNA immunization.
Correlation of leukemogenic potential of murine retroviruses with transcriptional tissue preference of the viral long terminal repeats.
Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.
Functional analysis of a retroviral host-range mutant: altered long terminal repeat sequences allow expression in embryonal carcinoma cells.
Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.
Human immunodeficiency virus type 1 vpr protein transactivation function: mechanism and identification of domains involved.
Identification of multiple regulatory elements of human L-histidine decarboxylase gene.
Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colony-stimulating factor gene by tumor necrosis factor.
Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC).
Negative regulatory element associated with potentially functional promoter and enhancer elements in the long terminal repeats of endogenous murine leukemia virus-related proviral sequences.
Packaging of intron-containing genes into retrovirus vectors by alphavirus vectors.
Reconstitution of the functional granulocyte macrophage colony stimulating factor promoter: evidence for distinct activation mechanisms that mediate the response to phorbol ester/calcium and human T cell leukemia virus type I Tax signals.
Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor.
Transcription from a spleen necrosis virus 5' long terminal repeat is suppressed in mouse cells.
Transient gene expression by SV40 promoter characterizes sequential differentiation of embryonal carcinoma F9 cells into primitive and visceral endoderm.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Leukemia, Erythroblastic, Acute
Characterization of the Duffy gene promoter: evidence for tissue-specific abolishment of expression in Fy(a-b-) of black individuals.
Characterization of the promoter region of the human c-kit proto-oncogene.
Enhancer function of a 53-bp repetitive element in the 5' flanking region of the human neutrophil elastase gene.
Evidence for a globin promoter-specific silencer element located upstream of the human delta-globin gene.
Hereditary overexpression of adenosine deaminase in erythrocytes: studies in erythroid cell lines and transgenic mice.
Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene.
Short-term efficient expression of transfected DNA in human hematopoietic cells by electroporation: definition of parameters and use of chemical stimulators.
The palindromic series I repeats in the simian cytomegalovirus major immediate-early promoter behave as both strong basal enhancers and cyclic AMP response elements.
Transient expression of foreign genes in lymphoid cells is enhanced by phorbol ester.
Leukemia, Large Granular Lymphocytic
Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1.
Leukemia, Monocytic, Acute
Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC).
Leukemia, Myeloid
Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene.
Transcriptional regulation of the vimentin-encoding gene in mouse myeloid leukemia M1 cells.
Leukemia, T-Cell
A novel method for analysis of viral proteinase activity encoded by hepatitis C virus in cultured cells.
Reconstitution of the functional granulocyte macrophage colony stimulating factor promoter: evidence for distinct activation mechanisms that mediate the response to phorbol ester/calcium and human T cell leukemia virus type I Tax signals.
Transient gene expression by SV40 promoter characterizes sequential differentiation of embryonal carcinoma F9 cells into primitive and visceral endoderm.
Lymphoma
A DNA binding protein regulated by IL-4 and by differentiation in B cells.
Ceramide activates NFkappaB by inducing the processing of p105.
Localization of the inducible enhancer in the mouse interleukin-5 gene that is responsive to T-cell receptor stimulation.
Malaria
A new tool for the serodiagnosis of acute Plasmodium falciparum malaria in individuals with primary infection.
Transfection of Plasmodium falciparum within human red blood cells.
Malaria, Falciparum
Transfection of Plasmodium falciparum within human red blood cells.
Marek Disease
Study on the structure of heteropolymer pp38/pp24 and its enhancement on the bi-directional promoter upstream of pp38 gene in Marek's disease virus.
Mastitis
Characterization of the chloramphenicol acetyltransferase variants encoded by the plasmids pSCS6 and pSCS7 from Staphylococcus aureus.
Measles
'Rescue' of mini-genomic constructs and viruses by combinations of morbillivirus N, P and L proteins.
Melanoma
17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production.
Expression of CD44 is repressed in neuroblastoma cells.
Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.
Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells.
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Metabolic Syndrome
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Neoplasm Metastasis
Endocervical involvement by endometrial carcinoma on fractional curettage: a clinicopathological study of 37 cases.
Neoplasms
11 beta-hydroxysteroid dehydrogenase activity in human lung cells and transcription regulation by glucocorticoids.
11 beta-Hydroxysteroid dehydrogenase and tissue specificity of androgen action in human prostate cancer cell LNCaP.
A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse.
A microsphere-liposome (microplex) vector for targeted gene therapy of cancer. II. In vivo biodistribution study in a solid tumor model.
A model for evaluating selective delivery of plasmid DNA to tumours via the vasculature.
A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.
A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells.
A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.
Activation of human multidrug resistance-1 gene promoter in response to heat shock stress.
An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene.
Antiandrogens inhibit human androgen receptor-dependent gene transcription activation in the human prostate cancer cells LNCaP.
Characterization and regulation of two testicular inhibin/activin beta B-subunit messenger ribonucleic acids that are transcribed from alternate initiation sites.
Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation.
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.
Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells.
Decreased glucocorticoid receptor activity following glucocorticoid receptor antisense RNA gene fragment transfection.
Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level.
Differential expression of the human gonadotropin alpha gene in ectopic and eutopic cells.
Differential regulation of mouse mammary tumor virus-bacterial chloramphenicol acetyltransferase chimeric gene by human mineralocorticoid hormone-receptor complexes.
Differential regulation of rat T-kininogen by tumor necrosis factor and interleukin-6.
Direct gene transfer to mouse melanoma by intratumor injection of free DNA.
DNA-mediated gene transfer into adult rat hepatocytes in primary culture.
Early gene expression in lymphoma-associated hamster polyomavirus viral genomes.
Effects of mitogens on androgen receptor-mediated transactivation.
Effects of some new antiepileptic drugs and progabide on glucocorticoid receptor-mediated gene transcription in LMCAT cells.
Endocervical involvement by endometrial carcinoma on fractional curettage: a clinicopathological study of 37 cases.
Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.
Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Altered hormone and antihormone specificity in gene transactivation.
Expression of plant tumor-specific proteins in minicells of Escherichia coli: a fusion protein of lysopine dehydrogenase with chloramphenicol acetyltransferase.
Expression of recombinant androgen receptor in cultured mammalian cells.
Extra mouse mammary tumor proviruses in DBA/2 mouse lymphomas acquire a selective advantage in lymphocytes by alteration in the U3 region of the long terminal repeat.
Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.
Generation of therapeutic T-lymphocytes after in vivo tumor transfection with an allogeneic class I major histocompatibility complex gene.
Hormonal induction of transfected genes depends on DNA topology.
Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression.
Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
Identification and cell type specificity of the tyrosine hydroxylase gene promoter.
Identification of a novel mammary cell line-specific enhancer element in the long terminal repeat of mouse mammary tumor virus, which interacts with its hormone-responsive element.
Improvement of gene transfer to cervical cancer cell lines using non-viral agents.
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells.
Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.
Interaction of antiandrogen-androgen receptor complexes with DNA and transcription activation.
Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.
Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D.
Involvement of protein kinase in environmental stress-induced activation of human multidrug resistance 1 (MDR1) gene promoter.
Isolation and characterization of the mouse P450 17 alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3',5'-monophosphate in MA-10 Leydig cells.
Lack of androgen receptor transcriptional activity in human keratinocytes.
Localization and induced expression of fusion genes in the rat lung.
Loss of androgen dependency with preservation of functional androgen receptors in androgen-dependent mouse tumor (Shionogi Carcinoma 115).
Mapping and characterization of the basal promoter of the human connexin26 gene.
Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity.
Negative control of the rat inhibin alpha subunit promoter in MA-10 Leydig tumour cells.
p53 stimulates promoter activity of the sgk. serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells.
Partial androgen insensitivity caused by an androgen receptor mutation at amino acid 907 (Gly-->Arg) that results in decreased ligand binding affinity and reduced androgen receptor messenger ribonucleic acid levels.
Phenylalanine-780 near the C-terminus of the mouse glucocorticoid receptor is important for ligand binding affinity and specificity.
Prolactin acts on the extreme 5' portion of MMTV LTR involving a mammary cell-specific enhancer.
Promoter region of the human platelet-derived growth factor A-chain gene.
Proteasome inhibitors reduce luciferase and beta-galactosidase activity in tissue culture cells.
Regulation of androgen receptor gene expression by steroids and retinoic acid in human breast-cancer cells.
Regulation of NF-kappaB and HIV-1 LTR activity in mouse L cells by ultraviolet radiation: LTR trans-activation in a nonirradiated genome in heterokaryons.
Repression of cAMP-induced expression of the mouse P450 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) by androgens.
Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor.
Specific region in hormone binding domain is essential for hormone binding and trans-activation by human androgen receptor.
Stable transfection of androgen receptor and MMTV-CAT into mammalian cells: inhibition of cat expression by anti-androgens.
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
Structures of regulatory regions in the human cytochrome P-450scc (desmolase) gene.
Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: immunogene approach.
The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.
The simian virus 40 minimal origin and the 72-base-pair repeat are required simultaneously for efficient induction of late gene expression with large tumor antigen.
The use of a DNA-binding domain replacement method for the detection of a potential TR3 orphan receptor response element in the mouse mammary tumor virus long terminal repeat.
Transactivating potential of the 3' open reading frame of murine mammary tumor virus.
Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells.
Transcription of the Epstein-Barr virus gene EBNA-1 from different promoters in nasopharyngeal carcinoma and B-lymphoblastoid cells.
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
Transcriptional activation by TR3 receptor, a member of the steroid receptor superfamily.
Transcriptional repression of a hormone-responsive promoter.
Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression.
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Neurilemmoma
Binding at an NFI site is modulated by cyclic AMP-dependent activation of myelin basic protein gene expression.
Neuroblastoma
A 5'-flanking region of the bovine tyrosine hydroxylase gene is involved in cell-specific expression, activation of gene transcription by phorbol ester, and transactivation by c-Fos and c-Jun.
Association of USF and c-Myc with a helix-loop-helix-consensus motif in the core promoter of the murine type II beta regulatory subunit gene of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase.
Autonomously replicating sequences identified in transcriptional regulatory regions of human N-myc gene.
Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells.
Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene.
Demonstration of an E-box and its CNS-related binding factors for transcriptional regulation of the mouse type 1 inositol 1,4,5-trisphosphate receptor gene.
Expression of a chimeric VIP gene is targeted to the intestine in transgenic mice.
Expression of CD44 is repressed in neuroblastoma cells.
Expression of the gene encoding human brain creatine kinase depends on sequences immediately following the transcription start point.
Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.
Identification of a retinoic acid response element in the human oxytocin promoter.
Lineage-specific regulation of the vasoactive intestinal peptide gene in neuroblastoma cells is conferred by 5.2 kilobases of 5'-flanking sequence.
Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene.
Okadaic acid markedly potentiates the heat-induced hsp 70 promoter activity.
The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function.
The human oxytocin gene promoter is regulated by estrogens.
The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2.
The mouse plasma membrane Ca2+ pump isoform 1 promoter: cloning and characterization.
The upstream region of the mouse N-myc gene: identification of an enhancer element that functions preferentially in neuroblastoma IMR32 cells.
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Newcastle Disease
High-level expression of a foreign gene from the most 3'-proximal locus of a recombinant Newcastle disease virus.
Obesity
Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Osteosarcoma
Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3.
Expression of a provirus of human T cell leukaemia virus type I by DNA transfection.
Expression of chloramphenicol acetyltransferase (CAT) from rodent type I collagen promoters in transfected osteosarcoma cells in vivo.
Human herpesvirus 6A ts suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters.
MDM2 suppresses p73 function without promoting p73 degradation.
p53 transactivity during in vitro osteoblast differentiation in a rat osteosarcoma cell line.
Parathyroid hormone (1-34)-mediated interleukin-6 induction.
Regions of the rat osteocalcin gene which mediate the effect of 1,25-dihydroxyvitamin D3 on gene transcription.
Structural and functional characterization of the human decorin gene promoter. A homopurine-homopyrimidine S1 nuclease-sensitive region is involved in transcriptional control.
Ovarian Neoplasms
Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter.
Papilloma
Spironolactone, an aldosterone antagonist, acts as an antiglucocorticosteroid on the mouse mammary tumor virus promoter.
Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product.
Pheochromocytoma
Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene.
Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway.
Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression.
Identification and cell type specificity of the tyrosine hydroxylase gene promoter.
Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene.
Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39.
The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2.
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.
Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.
Pituitary Neoplasms
d(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription.
Distance-dependent interactions between basal, cyclic AMP, and thyroid hormone response elements in the rat growth hormone promoter.
Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells.
Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression.
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Okadaic acid, a protein phosphatase inhibitor, enhances transcription of a receptor gene containing sequence A of the human prolactin promoter.
Plasmacytoma
NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.
Poliomyelitis
Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy.
Prostatic Neoplasms
Antiandrogens inhibit human androgen receptor-dependent gene transcription activation in the human prostate cancer cells LNCaP.
Expression of human prostatic acid phosphatase gene is regulated by upstream negative and positive elements.
Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.
Prostatic Neoplasms, Castration-Resistant
Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Altered hormone and antihormone specificity in gene transactivation.
Rabies
Ambisense gene expression from recombinant rabies virus: random packaging of positive- and negative-strand ribonucleoprotein complexes into rabies virions.
Retinoblastoma
Endogenous CRX expression and IRBP promoter activity in retinoblastoma cells.
Rhabdomyosarcoma
Deletional analysis of the promoter region of the human transferrin receptor gene.
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Rinderpest
'Rescue' of mini-genomic constructs and viruses by combinations of morbillivirus N, P and L proteins.
Sarcoma
Characterization of a 142-bp fragment of the murine c-fos oncogene promoter upstream of the SIF-binding element.
Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals.
Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays.
Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation.
Transient expression of RSVCAT in transgenic zebrafish made by electroporation.
Sarcoma, Avian
Baculovirus-mediated expression of bacterial genes in dipteran and mammalian cells.
Behavior of genes directly injected into the rat heart in vivo.
Camptothecin inhibits Tat-mediated transactivation of type 1 human immunodeficiency virus.
Characterization of the promoter for the alpha 1 (IV) collagen gene. DNA sequences within the first intron enhance transcription.
Comparison of various expression plasmids for the induction of immune response by DNA immunization.
Detection of transcription and translation in situ with biotinylated molecular probes in cells transfected with recombinant DNA plasmids.
Effect of intercistronic length on internal ribosome entry site (IRES) efficiency in bicistronic mRNA.
Efficiency of introns from various origins in fish cells.
Eukaryotic promoters drive gene expression in Escherichia coli.
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.
Expression of a prokaryotic gene in cultured lung endothelial cells after lipofection with a plasmid vector.
Galactosylated histone-mediated gene transfer and expression.
Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells.
Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation.
Human immunodeficiency virus tat-activated expression of poliovirus protein 2A inhibits mRNA translation.
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences.
Localization and induced expression of fusion genes in the rat lung.
Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation.
The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.
The introduction of biologically active foreign genes into human respiratory epithelial cells using electroporation.
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences.
Transactivation of the Rous sarcoma virus long terminal repeat promoter by Marek's disease virus.
Transfer of genes into hematopoietic cells using recombinant DNA viruses.
Seizures
Seizures with single therapeutic dose of isoniazid.
Severe Combined Immunodeficiency
Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.
Starvation
Chloramphenicol induction of cat-86 requires ribosome stalling at a specific site in the leader.
Drug-free induction of a chloramphenicol acetyltransferase gene in Bacillus subtilis by stalling ribosomes in a regulatory leader.
Dual regulation of the ugp operon by phosphate and carbon starvation at two interspaced promoters.
Induction of cat-86 by chloramphenicol and amino acid starvation in relaxed mutants of Bacillus subtilis.
Superinfection
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Differential activation of hybrid genes containing herpes simplex virus immediate-early or delayed-early promoters after superinfection of stable DNA-transfected cell lines.
Transactivation of the major capsid protein gene of herpes simplex virus type 1 requires a cellular transcription factor.
Teratocarcinoma
Negative and positive regulation by a short segment in the 5'-flanking region of the human cytomegalovirus major immediate-early gene.
Thymoma
A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction.
Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.
Tuberculosis
Changed activation of HIV-1 LTR in monocytoid cells by mycobacteria with temporal progression of infection.
Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication by transcriptional activation at the long terminal repeat.
Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in human monocytic cells.
Risk Factors for Sputum Positive Pulmonary Tuberculosis Retreatment Cases and Factors Responsible for Treatment Outcome.
TNF-alpha-mediated activation of HIV-1 LTR in monocytoid cells by mycobacteria.
Tuberculosis, Pulmonary
Effect of green tea extract (catechins) in reducing oxidative stress seen in patients of pulmonary tuberculosis on DOTS Cat I regimen.
Incidence of tuberculosis in enlarged neck nodes, our experience.
Seizures with single therapeutic dose of isoniazid.
Urinary Bladder Neoplasms
Structural and functional analysis of the control region of the human DNA topoisomerase II alpha gene in drug-resistant cells.
Vaccinia
Activation of HIV-1 enhancer sequence by vaccinia virus.
Activation of the human immunodeficiency virus type 1 long terminal repeat by vaccinia virus.
An NH2-terminal peptide from the vaccinia virus L1R protein directs the myristylation and virion envelope localization of a heterologous fusion protein.
Cell-free translation of a chimeric eucaryotic-procaryotic message yields functional chloramphenicol acetyltransferase.
Determination of the promoter region of an early vaccinia virus gene encoding thymidine kinase.
Determination of the transcriptional regulatory region of a vaccinia virus late gene.
Eukaryotic transient expression system dependent on transcription factors and regulatory DNA sequences of vaccinia virus.
Functional analysis of the 5' flanking sequence of a vaccinia virus late gene.
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.
In vitro mutagenesis of the promoter region for a vaccinia virus gene: evidence for tandem early and late regulatory signals.
Increased expression in vivo and in vitro of foreign genes directed by A-type inclusion body hybrid promoters in recombinant vaccinia viruses.
Reduced steady-state levels of vaccinia virus-specific early mRNAs in interferon-treated chick embryo fibroblasts.
Regulation of foreign gene in fowlpox virus by a vaccinia virus promoter.
The role of simian virus 5 V protein on viral RNA synthesis.
Use of vaccinia virus vectors to study the synthesis, intracellular localization, and action of the human immunodeficiency virus trans-activator protein.
Vesicular Stomatitis
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly.
Virus Diseases
Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors.
IkappaB-mediated inhibition of virus-induced beta interferon transcription.
Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.
Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection.
Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV.
Visna
cis- and trans-acting transcriptional regulation of visna virus.
Molecular mechanisms of visna virus Tat: identification of the targets for transcriptional activation and evidence for a post-transcriptional effect.
Nucleotide sequence and transcriptional activity of the caprine arthritis-encephalitis virus long terminal repeat.
The CAEV tat gene trans-activates the viral LTR and is necessary for efficient viral replication.
The visna virus long terminal repeat directs expression of a reporter gene in activated macrophages, lymphocytes, and the central nervous systems of transgenic mice.
Whooping Cough
Autogenous regulation of the Bordetella pertussis bvgABC operon.
The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes.
Wilms Tumor
The human gene for renin-binding protein.
Xeroderma Pigmentosum
Host cell reactivation by human cells of DNA expression vectors damaged by ultraviolet radiation or by acid-heat treatment.
Lack of DNA enzymatic photoreactivation in HeLa cell-free extracts.
Quantification of expression of linked cloned genes in a simian virus 40-transformed xeroderma pigmentosum cell line.
Transient expression of a plasmid gene, a tool to study DNA repair in human cells: defect of DNA repair in Cockayne syndrome; one thymine cyclobutane dimer is sufficient to block transcription.