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Information on EC 2.1.1.44 - L-histidine Nalpha-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.44 L-histidine Nalpha-methyltransferase
IUBMB Comments
Part of the biosynthetic pathway of ergothioneine.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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Synonyms
dimethylhistidine methyltransferase, EgtD, histidine-alpha-N-methyltransferase, methyltransferase, histidine Nalpha-, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine
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overall reaction
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S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine
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(1a)
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S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine
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(1c)
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S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine
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(1b)
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PATHWAY SOURCE
PATHWAYS
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