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Arabidopsis homolog of trithorax-1
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Ash2L
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a subunit of histone H3 lysine 4 methyltransferase complexes
COMPASS chromatin complex
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-
COMPASS histone methyltransferase
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Dpy-30
-
a subunit of histone H3 lysine 4 methyltransferase complexes
EC 2.1.1.43
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formerly, part transferred
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H3K4 trimethyltransferase
-
H3K4-specific methyltransferase
-
-
H3K4me3 methyltransferase
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-
histone 3 lysine 4 methyltransferase
histone 3 lysine 4 trimethyltransferase
-
histone H3 lysine 4 methyltransferase
histone H3 lysine 4 methyltransferase activity
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histone H3 lysine 4 trimethyltransferase
histone H3 methyltransferase
histone H3, lysine 4 methyltransferase
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histone H3-lysine-4 methyltransferase
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histone H3K4 methyltransferase
histone H3K4 methyltransferase complex
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histone H3K4-methyltransferase
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histone lysine methyltransferase
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histone methyltransferase complex
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hybrid sterility protein 1
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mixed lineage leukemia protein
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MLL3/MLL4
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a histone H3K4 methyltransferase complex
PA1
-
subunit of the MLL3/MLL4 complex
PR domain-containing protein 7
-
RbBP5
-
a subunit of histone H3 lysine 4 methyltransferase complexes
SDG701
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gene name, SET DOMAIN GROUP701
SET domain group 26
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also known as Absent, Small, or Homeotic discs 1 homolog 1
set1 histone H3-Lys4 methyltransferase complex
COMPASS
-
-
COMPASS
-
the yeast H3K4 methyltransferase complex, Set1 complex or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated proteins: Swd1, Swd2, Swd3, Spp1, Bre2, Sdc1, and Shg1
H3K4 methyltransferase
-
-
H3K4 methyltransferase
-
-
H3K4 methyltransferase
-
-
H3K4 methyltransferase
-
-
H3K4 methyltransferase
-
-
histone 3 lysine 4 methyltransferase
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-
histone 3 lysine 4 methyltransferase
-
-
-
histone 3 lysine 4 methyltransferase
-
-
histone H3 lysine 4 methyltransferase
-
-
histone H3 lysine 4 methyltransferase
-
-
histone H3 lysine 4 trimethyltransferase
-
-
histone H3 lysine 4 trimethyltransferase
-
histone H3 methyltransferase
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-
histone H3 methyltransferase
-
-
histone H3K4 methyltransferase
-
-
histone H3K4 methyltransferase
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HMT
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KMT2A
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KMT2B
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KMT2C
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KMT2D
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KMT2F
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-
KMT2G
-
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MLL1
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-
MLL2
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-
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-
MLL3
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MLL3
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mixed-lineage leukemia 3, also known as KMT2C
MLL3
-
part of the activating signal cointegrator-2 complex
MLL4
-
-
-
-
MLL4
-
mixed-lineage leukemia 4, also known as ALR, MLL2, or KMT2D
MLL4
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part of the activating signal cointegrator-2 complex
PRDM7
-
-
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Prdm9
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-
Prdm9
the Prdm9 gene is also known as Meisetz
SET1
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-
SET1
-
catalytic subunit of COMPASS
set1 histone H3-Lys4 methyltransferase complex
-
set1 histone H3-Lys4 methyltransferase complex
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-
Set1p
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Setd1A
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-
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Setd1B
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-
Smyd3
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-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-methionine + ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
S-adenosyl-L-homocysteine + ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
-
-
-
?
S-adenosyl-L-methionine + ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
S-adenosyl-L-homocysteine + ART(Kme3)QTARKSTGGKAPRKQLATKAA-GK-biotin
highest activity
-
-
?
S-adenosyl-L-methionine + ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
S-adenosyl-L-homocysteine + ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
-
-
-
?
S-adenosyl-L-methionine + histone 3(K4)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + N-methylated histone H3(K4)
S-adenosyl-L-methionine + histone H3(K79)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
-
-
?
additional information
?
-
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
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-
-
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?
S-adenosyl-L-methionine + histone H3(K4)
?
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-
-
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?
S-adenosyl-L-methionine + histone H3(K4)
?
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-
-
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?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
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?
S-adenosyl-L-methionine + histone H3(K4)
?
-
menin appears to be essential for MLL-mediated histone H3(K4) methylation
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-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
H3K4 methyltransferase dSet1 is predominantly responsible for histone H3(K4) trimethylation
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-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
ASCOM-MLL3 and ASCOM-MLL4 function as redundant but crucial histone H3(K4)-trimethylating coactivator complexes for p53
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-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
trimethylation of histone H3(K4)
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
-
histone H3(K4) dimethylation by Set1 leads to reduced histone acetylation levels near 5' ends of genes
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + N-methylated histone H3(K4)
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + N-methylated histone H3(K4)
-
-
-
?
additional information
?
-
Set1/CXXC finger protein 1 complex transfers tritiated methyl groups onto both purified core histones and recombinant histone H3, fails to catalyze methylation of histone H4, specificity for histone H3-Lys4 methylation
-
-
?
additional information
?
-
-
Set1/CXXC finger protein 1 complex transfers tritiated methyl groups onto both purified core histones and recombinant histone H3, fails to catalyze methylation of histone H4, specificity for histone H3-Lys4 methylation
-
-
?
additional information
?
-
-
CXXC finger protein 1 is a component of the Setd1A and Setd1B histone H3K4 methyltransferase complex
-
-
?
additional information
?
-
no activity with ARTAQTARKSTGGKAPRKQLATKAA-GK-biotin, ATKAARKSAPATGGVKKPHRYRPG-GK-biotin, ATKAARKSAPATGGV(Kme1)KPHRYRPGGK-biotin, and ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin
-
-
?
additional information
?
-
-
SET1 mRNA is associated with a SET1C sub-complex
-
-
?
additional information
?
-
-
fusing the enzyme to RNA polymerase II results in extended histone H3 lysine 4 methylation throughout the gene
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
-
-
?
additional information
?
-
-
SET1 mRNA is associated with a SET1C sub-complex
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0002 - 0.002
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
0.00026 - 0.004
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
0.00017 - 0.0017
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
0.014 - 0.9
S-adenosyl-L-methionine
0.0002
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.0003
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
0.0007
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
0.001
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
0.002
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.00026
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
0.002
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
0.0033
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.0035
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
0.004
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.00017
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
0.0004
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.0004
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
0.0008
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
0.0017
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.014
S-adenosyl-L-methionine
mutant enzyme S357Y, at pH 9.0 and 23°C
0.025
S-adenosyl-L-methionine
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.056
S-adenosyl-L-methionine
mutant enzyme S312W, at pH 9.0 and 23°C
0.2
S-adenosyl-L-methionine
mutant enzyme S289N, at pH 9.0 and 23°C
0.9
S-adenosyl-L-methionine
wild type enzyme, at pH 9.0 and 23°C
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0.0022 - 7.5
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
0.0167 - 6.444
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
0.0025 - 5.833
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
0.0186 - 5.583
S-adenosyl-L-methionine
0.0022
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
0.0036
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.0333
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
6
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
7.5
ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.0167
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
0.021
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.053
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
4.167
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
6.444
ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
0.0025
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
wild type enzyme, at pH 9.0 and 23°C
0.0031
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N, at pH 9.0 and 23°C
0.0139
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S312W, at pH 9.0 and 23°C
4.806
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S357Y, at pH 9.0 and 23°C
5.833
ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
0.0186
S-adenosyl-L-methionine
mutant enzyme S312W, at pH 9.0 and 23°C
0.0194
S-adenosyl-L-methionine
mutant enzyme S289N, at pH 9.0 and 23°C
0.053
S-adenosyl-L-methionine
wild type enzyme, at pH 9.0 and 23°C
3.056
S-adenosyl-L-methionine
mutant enzyme S289N/S312W/S357Y, at pH 9.0 and 23°C
5.583
S-adenosyl-L-methionine
mutant enzyme S357Y, at pH 9.0 and 23°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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malfunction
Prdm9-null mice show arrest of spermatogenesis and oogenesis at pachynema, impairment of double-strand break repair, chromosome asynapsis, and disrupted sex-body formation
malfunction
-
targeted inactivation of MLL3 H3K4 methyltransferase activity in the mouse causes ureter epithelial tumors, about 50% of MLL-deficient mice display unusual hyperproliferation and tumors in the innermost layer of ureter cells located close to the renal pelvis
malfunction
-
histone H3(K4) di- and trimethylations are significantly reduced in dSet1 mutants during late larval und post-larval stages
malfunction
-
an enzyme deficiency promotes fat accumulation in worms with a specific enrichment of mono-unsaturated fatty acids
malfunction
enzyme knockout spontaneously induces medulloblastoma. Enzyme loss upregulates oncogenic Ras and Notch pathways while downregulating neuronal gene expression programs. Enzyme loss downregulates tumor suppressor genes (e.g., Dnmt3a and Bcl6). Enzyme loss increases cell proliferation in the cerebellum but negatively impacts cerebellar neurons
malfunction
-
enzyme loss induces benomyl resistance. Enzyme mutants display a thick mitotic spindle and a defect in the release of the spindle assembly checkpoint
malfunction
-
Mll1 knockout is embryonic lethal and affects development of the hematopoietic system. Germ-line deletions of Mll2 result in delayed development early in embryogenesis, neural tube defects and widespread apoptosis. Knockdown of Mll3 or knockout of Mll4 in hematopoietic stem/multipotent progenitor cells (HSPCs) results in impaired differentiation of HSPCs and increased HSPC numbers. Erythroid-specific Setd1a deletion partially blocked erythropoiesis, resulting in mild anemia
malfunction
-
enzyme loss induces benomyl resistance. Enzyme mutants display a thick mitotic spindle and a defect in the release of the spindle assembly checkpoint
-
metabolism
the enzyme indirectly downregulates Ras activators by enhancing DNMT3A-mediated DNA methylation. The enzyme indirectly antagonizes Notch pathway components (e.g., Hes1 and Jag1) by upregulating SIRT1/BCL6-mediated H4K16 deacetylation
metabolism
the enzyme is involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3. The enzyme is involved in epigenetic transcriptional regulation
physiological function
-
Dpy-30 functions in the endosome to trans-Golgi network transport of cation-independent mannose 6-phosphate receptor, its knockdown results in the enrichment of internalized cation-independent mannose 6-phosphate receptor and recycling endosomes near cell protrusions. Dpy-30 and probably histone H3 lysine 4 methyltransferase play a role in the endosomal transport of specific cargo proteins
physiological function
-
MLL3 and MLL4 function redundantly with farnesoid X receptor transactivation
physiological function
-
Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. dSet1-dependent histone H3 lysine 4 trimethylation is responsible for the generation of a chromatin structure at active promoters that ensures optimal polymerase II release into productive elongation
physiological function
-
dSet1 is the main histone H3(K4) di- and tri-methyltransferase throughout Drosophila development. dSet1 interacts with members of a putative Drosophila COMPASS (complex of proteins associated with Set1) which is functionally required for histone H3(K4) methylation
physiological function
-
trxG complexes in Arabidopsis thaliana involve different sets of histone lysine methyltransferases that are engaged in multiple developmental processes
physiological function
-
expression of the clock gene frequencey (frq) is altered in strains lacking isoform SEt1 under both circadian- and light-regulated gene expression. SET1 is required for DNA methylation in the frq promoter
physiological function
-
histone H3 lysine 4 trimethylation by isoform Set1 regulates both the acetylated histone variant H2A.Z/v exchange and histone acetyltransferase activities of Tip60 complexes to ensure that nucleosome destabilization at promoters only occurs during transcription
physiological function
isoform KMT2D functions as a bona fide tumor suppressor and its genetic ablation in B cells promotes lymphoma development in mice. KMT2D deficiency also delays germinal center involution and impedes B cell differentiation and class switch recombination. KMT2D affects methylation of lysine 4 on histone H3 (H3K4) and expression of a set of genes, including those in the CD40, JAK-STAT, Toll-like receptor and B cell receptor signaling pathways. Other KMT2D target genes include frequently mutated tumor suppressor genes such as TNFAIP3, SOCS3 and TNFRSF14
physiological function
knock-down of either histone H3 lysine methyltransferase Smyd3 or SetD7 genes leads to severe defects in cardiac morphogenesis without altering the expression pattern of heart markers, including cmlc2, vmhc, and amhc. Double knock-down of both Smyd3 and SetD7 causes synergistic defects in heart development. Overexpression of these genes also causes the heart morphogenesis defect in zebrafish
physiological function
-
MLL3 and MLL4 act as tumor supressors in leukemia
physiological function
-
the enzyme is crucial for proper sporophytic plant development as well as for gametophytic transmission that directly impacts rice grain production
physiological function
-
the enzyme regulates lifespan in Caenorhabditis elegans
physiological function
-
the enzyme's catalytic activity is required for a normal response to microtubule depolymerization
physiological function
-
the enzyme's catalytic activity is required for a normal response to microtubule depolymerization
-
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Yeates, T.O.
Structures of SET domain proteins: protein lysine methyltransferases make their mark
Cell
111
5-7
2002
Homo sapiens
brenda
Lee, J.H.; Skalnik, D.G.
CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
J. Biol. Chem.
280
41725-41731
2005
Mus musculus, Homo sapiens (O15047), Homo sapiens
brenda
Raman, S.B.; Nguyen, M.H.; Zhang, Z.; Cheng, S.; Jia, H.Y.; Weisner, N.; Iczkowski, K.; Clancy, C.J.
Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis
Mol. Microbiol.
60
697-709
2006
Saccharomyces cerevisiae, Candida albicans, Candida albicans CAI12
brenda
Kim, T.; Buratowski, S.
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions
Cell
137
259-272
2009
Saccharomyces cerevisiae
brenda
Wu, X.; Hua, X.
Menin, histone H3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective
Curr. Mol. Med.
8
805-815
2008
Drosophila melanogaster, Homo sapiens
brenda
Butler, J.S.; Lee, J.H.; Skalnik, D.G.
CFP1 interacts with DNMT1 independently of association with the Setd1 histone H3K4 methyltransferase complexes
DNA Cell Biol.
27
533-543
2008
Homo sapiens
brenda
Halbach, A.; Zhang, H.; Wengi, A.; Jablonska, Z.; Gruber, I.M.; Halbeisen, R.E.; Dehe, P.M.; Kemmeren, P.; Holstege, F.; Geli, V.; Gerber, A.P.; Dichtl, B.
Cotranslational assembly of the yeast SET1C histone methyltransferase complex
EMBO J.
28
2959-2970
2009
Saccharomyces cerevisiae
brenda
Xu, Z.; Gong, Q.; Xia, B.; Groves, B.; Zimmermann, M.; Mugler, C.; Mu, D.; Matsumoto, B.; Seaman, M.; Ma, D.
A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking
J. Cell Biol.
186
343-353
2009
Rattus norvegicus
brenda
Kim, D.H.; Lee, J.; Lee, B.; Lee, J.W.
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity
Mol. Endocrinol.
23
1556-1562
2009
Mus musculus
brenda
Lee, J.; Kim, D.H.; Lee, S.; Yang, Q.H.; Lee, D.K.; Lee, S.K.; Roeder, R.G.; Lee, J.W.
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
Proc. Natl. Acad. Sci. USA
106
8513-8518
2009
Mus musculus
brenda
Mihola, O.; Trachtulec, Z.; Vlcek, C.; Schimenti, J.; Forejt, J.
A mouse speciation gene encodes a meiotic histone H3 methyltransferase
Science
323
373-375
2009
Mus musculus (C4MLH8), Mus musculus
brenda
Ardehali, M.B.; Mei, A.; Zobeck, K.L.; Caron, M.; Lis, J.T.; Kusch, T.
Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription
EMBO J.
30
2817-2828
2011
Drosophila melanogaster
brenda
Hallson, G.; Hollebakken, R.E.; Li, T.; Syrzycka, M.; Kim, I.; Cotsworth, S.; Fitzpatrick, K.A.; Sinclair, D.A.; Honda, B.M.
dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development
Genetics
190
91-100
2012
Drosophila melanogaster
brenda
Mersman, D.P.; Du, H.N.; Fingerman, I.M.; South, P.F.; Briggs, S.D.
Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression
J. Biol. Chem.
287
2652-2665
2012
Saccharomyces cerevisiae
brenda
Valencia-Morales, M.D.; Camas-Reyes, J.A.; Cabrera-Ponce, J.L.; Alvarez-Venegas, R.
The Arabidopsis thaliana SET-domain-containing protein ASHH1/SDG26 interacts with itself and with distinct histone lysine methyltransferases
J. Plant Res.
125
679-692
2012
Arabidopsis thaliana
brenda
Cho, Y.W.; Hong, S.; Ge, K.
Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex
Methods Mol. Biol.
809
465-472
2012
Homo sapiens
brenda
Raduwan, H.; Isola, A.L.; Belden, W.J.
Methylation of histone H3 on lysine 4 by the lysine methyltransferase SET1 protein is needed for normal clock gene expression
J. Biol. Chem.
288
8380-8390
2013
Neurospora crassa
brenda
Kim, J.D.; Kim, E.; Koun, S.; Ham, H.J.; Rhee, M.; Kim, M.J.; Huh, T.L.
Proper activity of histone H3 lysine 4 (H3K4) methyltransferase is required for morphogenesis during zebrafish cardiogenesis
Mol. Cells
38
580-586
2015
Danio rerio (Q6DHG0), Danio rerio
brenda
Ortega-Molina, A.; Boss, I.W.; Canela, A.; Pan, H.; Jiang, Y.; Zhao, C.; Jiang, M.; Hu, D.; Agirre, X.; Niesvizky, I.; Lee, J.E.; Chen, H.T.; Ennishi, D.; Scott, D.W.; Mottok, A.; Hother, C.; Liu, S.; Cao, X.J.; Tam, W.; Shaknovich, R.; Garcia, B.A.; Gascoyne, R.D.; Ge, K.; Shilatifard, A.; Elemento, O.; Nussenzweig, A.; Melnick, A.M.; Wendel, H.G.
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
Nat. Med.
21
1199-1208
2015
Mus musculus (Q6PDK2)
brenda
Kusch, T.; Mei, A.; Nguyen, C.
Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression
Proc. Natl. Acad. Sci. USA
111
4850-4855
2014
Drosophila melanogaster
brenda
Yang, W.; Ernst, P.
Distinct functions of H3K4 methyltransferases in normal and malignant hematopoiesis
Curr. Opin. Hematol.
24
322-328
2017
Mus musculus
brenda
Schibler, A.; Koutelou, E.; Tomida, J.; Wilson-Pham, M.; Wang, L.; Lu, Y.; Cabrera, A.P.; Chosed, R.J.; Li, W.; Li, B.; Shi, X.; Wood, R.D.; Dent, S.Y.
Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2
Genes Dev.
30
1187-1197
2016
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
brenda
Blazer, L.L.; Lima-Fernandes, E.; Gibson, E.; Eram, M.S.; Loppnau, P.; Arrowsmith, C.H.; Schapira, M.; Vedadi, M.
PR domain-containing protein 7 (PRDM7) is a histone 3 lysine 4 trimethyltransferase
J. Biol. Chem.
291
13509-13519
2016
Homo sapiens (Q9NQW5)
brenda
Soares, L.M.; He, P.C.; Chun, Y.; Suh, H.; Kim, T.; Buratowski, S.
Determinants of histone H3K4 methylation patterns
Mol. Cell
68
773-785.e6
2017
Saccharomyces cerevisiae
brenda
Dhar, S.S.; Zhao, D.; Lin, T.; Gu, B.; Pal, K.; Wu, S.J.; Alam, H.; Lv, J.; Yun, K.; Gopalakrishnan, V.; Flores, E.R.; Northcott, P.A.; Rajaram, V.; Li, W.; Shilatifard, A.; Sillitoe, R.V.; Chen, K.; Lee, M.G.
MLL4 is required to maintain broad H3K4me3 peaks and super-enhancers at tumor suppressor genes
Mol. Cell
70
825-841.e6
2018
Mus musculus (Q6PDK2)
brenda
Han, S.; Schroeder, E.A.; Silva-Garcia, C.G.; Hebestreit, K.; Mair, W.B.; Brunet, A.
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan
Nature
544
185-190
2017
Caenorhabditis elegans
brenda
Liu, K.; Yu, Y.; Dong, A.; Shen, W.H.
SET DOMAIN GROUP701 encodes a H3K4-methytransferase and regulates multiple key processes of rice plant development
New Phytol.
215
609-623
2017
Oryza sativa
brenda
Zhang, Y.; Li, C.; Yang, Z.
Is MYND domain-mediated assembly of SMYD3 complexes involved in calcium dependent signaling?
Front. Mol. Biosci.
6
121
2019
Homo sapiens (Q9H7B4)
brenda