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2 adenosyl-L-methionine + 1,2,3,4-4H-6,7-isoquinolinediol
2 S-adenosyl-L-homocysteine + 1,2,3,4-4H-6-methoxy-7-isoquinolinol + 1,2,3,4-4H-7-methoxy-6-isoquinolinol
1,2,3,4-4H-6-methoxy-7-isoquinolinol and 1,2,3,4-4H-7-methoxy-6-isoquinolinol are produced in the ratio 10.5:1
-
-
?
2 S-adenosyl-L-methionine + (-)-epinephrine
2 S-adenosyl-L-homocysteine + 4-O-methylepinephrine + 3-O-methylepinephrine
4-O-methylepinephrine and 3-O-methylepinephrine are produced in the ratio 6.0:1
-
-
?
2 S-adenosyl-L-methionine + (-)-norepinephrine
2 S-adenosyl-L-homocysteine + 4-O-methylnorepinephrine + 3-O-methylnorepinephrine
4-O-methylnorepinephrine and 3-O-methylnorepinephrine are produced in the ratio 14.7:1
-
-
?
2 S-adenosyl-L-methionine + 3,4,5-trihydroxybenzaldehyde
2 S-adenosyl-L-homocysteine + 3,5-dihydroxy-4-methoxybenzaldehyde + 5-hydroxyvanillin
3,5-dihydroxy-4-methoxybenzaldehyde and 5-hydroxyvanillin are produced in the ratio 1:99.9
-
-
?
2 S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde
2 S-adenosyl-L-homocysteine + vanillin + isovanillin
2 S-adenosyl-L-methionine + 3,4-dihydroxybenzylamine
2 S-adenosyl-L-homocysteine + 3-hydroxy-4-methoxybenzylamine + 4-hydroxy-3-methoxybenzylamine
3-hydroxy-4-methoxybenzylamine and 4-hydroxy-3-methoxybenzylamine are produced in the ratio 21.4:1
-
-
?
2 S-adenosyl-L-methionine + 4-bromo-catechol
2 S-adenosyl-L-homocysteine + 5-bromo-2-methoxyphenol + 4-bromo-2-methoxyphenol
5-bromo-2-methoxyphenol and 4-bromo-2-methoxyphenol are produced in the ratio 54.8:1
-
-
?
2 S-adenosyl-L-methionine + 4-fluoro-catechol
2 S-adenosyl-L-homocysteine + 5-fluoro-2-methoxyphenol + 4-fluoro-2-methoxyphenol
5-fluoro-2-methoxyphenol and 4-fluoro-2-methoxyphenol are produced in the ratio 1.5:1
-
-
?
2 S-adenosyl-L-methionine + 5-hydroxyvanillin
2 S-adenosyl-L-homocysteine + 3,4-dimethoxy-5-hydroxybenzaldehyde + 3,5-dimethoxy-4-hydroxybenzaldehyde
3,4-dimethoxy-5-hydroxybenzaldehyde and 3,5-dimethoxy-4-hydroxybenzaldehyde are produced in the ratio 1:27.9
-
-
?
2 S-adenosyl-L-methionine + caffeic acid
2 S-adenosyl-L-homocysteine + ferulic acid + isoferulic acid
2 S-adenosyl-L-methionine + dopamine
2 S-adenosyl-L-homocysteine + 4-O-methyldopamine + 3-O-methyldopamine
4-O-methyldopamine and 3-O-methyldopamine are produced in the ratio 83.8:1
-
-
?
2 S-adenosyl-L-methionine + ethyl 3,4-dihydroxybenzoate
2 S-adenosyl-L-homocysteine + ethyl 3-hydroxy-4-methoxybenzoate + ethyl 4-hydroxy-3-methoxybenzoate
ethyl 3-hydroxy-4-methoxybenzoate and ethyl 4-hydroxy-3-methoxybenzoate are produced in the ratio 1:99.9
-
-
?
2 S-adenosyl-L-methionine + higenamine
2 S-adenosyl-L-homocysteine + coclaurine + isococlaurine
coclaurine and isococlaurine are produced in the ratio 99.9:1
-
-
?
2 S-adenosyl-L-methionine + norbelladine
2 S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + 3'-O-methylnorbelladine
S-adenosyl-L-methionine + dopamine
?
-
-
-
?
S-adenosyl-L-methionine + N-methylnorbelladine
?
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
additional information
?
-
2 S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde
2 S-adenosyl-L-homocysteine + vanillin + isovanillin
-
-
-
-
?
2 S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde
2 S-adenosyl-L-homocysteine + vanillin + isovanillin
vanillin and isovanillin are produced in the ratio 1:10.5
-
-
?
2 S-adenosyl-L-methionine + caffeic acid
2 S-adenosyl-L-homocysteine + ferulic acid + isoferulic acid
-
-
-
-
?
2 S-adenosyl-L-methionine + caffeic acid
2 S-adenosyl-L-homocysteine + ferulic acid + isoferulic acid
ferulic acid and isoferulic acid are produced in the ratio 1:1.3
-
-
?
2 S-adenosyl-L-methionine + norbelladine
2 S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + 3'-O-methylnorbelladine
-
-
-
-
?
2 S-adenosyl-L-methionine + norbelladine
2 S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + 3'-O-methylnorbelladine
the enzyme exhibis both para- and meta-O-methylation activities toward norbelladine to give 4'- and 3'-Omethylnorbelladine
-
-
?
2 S-adenosyl-L-methionine + norbelladine
2 S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + 3'-O-methylnorbelladine
the enzyme exhibis both para- and meta-O-methylation activities toward norbelladine to give 4'- and 3'-O-methylnorbelladine. 4'-O-Methylnorbelladine and 3'-O-methylnorbelladine in the ratio of 3.5:1
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
Galanthus sp.
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
4'-O-methylnorbelladine is an universal precursor of all the primary Amaryllidaceae alkaloid skeletons
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
?
additional information
?
-
-
no activity with vanillin, isovanillin, o-vanillin or tyramine
-
-
-
additional information
?
-
no activity with caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde, and tyramine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 S-adenosyl-L-methionine + norbelladine
2 S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + 3'-O-methylnorbelladine
the enzyme exhibis both para- and meta-O-methylation activities toward norbelladine to give 4'- and 3'-Omethylnorbelladine
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
Galanthus sp.
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
4'-O-methylnorbelladine is an universal precursor of all the primary Amaryllidaceae alkaloid skeletons
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
?
S-adenosyl-L-methionine + norbelladine
S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine
-
-
-
?
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NOMT2_NARAP
239
0
27093
Swiss-Prot
other Location (Reliability: 2)
NOMT3_NARAP
239
0
27131
Swiss-Prot
other Location (Reliability: 2)
NOMT4_NARAP
239
0
27137
Swiss-Prot
other Location (Reliability: 2)
NOMT5_NARAP
239
0
27137
Swiss-Prot
other Location (Reliability: 2)
NOMT_NARAP
239
0
27156
Swiss-Prot
other Location (Reliability: 2)
NOMT_NARPS
239
0
27194
Swiss-Prot
other Location (Reliability: 2)
A0A2I0BEU9_9ASPA
293
0
33029
TrEMBL
Chloroplast (Reliability: 3)
A0A835Q1Y7_VANPL
382
0
42825
TrEMBL
other Location (Reliability: 4)
A0A2I0WMY2_9ASPA
228
0
26101
TrEMBL
other Location (Reliability: 5)
A0A6B9TNK2_9ASPA
239
0
27201
TrEMBL
other Location (Reliability: 2)
F2YP46_VANPL
296
0
33245
TrEMBL
Chloroplast (Reliability: 5)
A0A2I0V853_9ASPA
58
0
6655
TrEMBL
other Location (Reliability: 3)
A0A5P1FFU9_ASPOF
313
0
34678
TrEMBL
other Location (Reliability: 3)
A0A5C2H154_LYCRD
239
0
27183
TrEMBL
other Location (Reliability: 2)
A0A835Q125_VANPL
248
0
28122
TrEMBL
other Location (Reliability: 2)
A0A835PSX1_VANPL
276
0
30710
TrEMBL
Secretory Pathway (Reliability: 3)
A0A835Q130_VANPL
283
1
32546
TrEMBL
Secretory Pathway (Reliability: 5)
A0A835VA11_VANPL
196
0
21961
TrEMBL
other Location (Reliability: 4)
A0A835PY36_VANPL
239
0
26891
TrEMBL
other Location (Reliability: 2)
A0A2I0XJ83_9ASPA
190
0
21458
TrEMBL
other Location (Reliability: 4)
A0A2I0AG13_9ASPA
133
0
14577
TrEMBL
other Location (Reliability: 5)
A0A835RTX6_VANPL
156
0
17546
TrEMBL
Chloroplast (Reliability: 4)
A0A097PJ38_DENOF
239
0
27085
TrEMBL
other Location (Reliability: 2)
A0A835U8H5_VANPL
248
0
28054
TrEMBL
other Location (Reliability: 2)
A0A835Q467_VANPL
239
0
27025
TrEMBL
other Location (Reliability: 2)
A0A346CM52_NARTA
239
0
27137
TrEMBL
other Location (Reliability: 2)
A0A835PDI7_VANPL
239
0
26952
TrEMBL
other Location (Reliability: 2)
A0A2I0XJ65_9ASPA
187
0
20907
TrEMBL
other Location (Reliability: 5)
A0A5P1FQM7_ASPOF
85
0
9476
TrEMBL
Secretory Pathway (Reliability: 5)
A0A835PU84_VANPL
276
0
30737
TrEMBL
Secretory Pathway (Reliability: 4)
A0A835RPE2_VANPL
296
0
33224
TrEMBL
Chloroplast (Reliability: 4)
A0A4P8FB83_DENOF
239
0
27145
TrEMBL
other Location (Reliability: 2)
A0A2I0XCH4_9ASPA
255
0
28768
TrEMBL
other Location (Reliability: 2)
A0A2I0B0E4_9ASPA
262
1
29622
TrEMBL
Secretory Pathway (Reliability: 1)
A0A835U8I9_VANPL
272
0
30667
TrEMBL
other Location (Reliability: 2)
A0A835VA40_VANPL
210
0
23489
TrEMBL
Mitochondrion (Reliability: 4)
F2YP45_VANPL
248
0
27930
TrEMBL
other Location (Reliability: 4)
A0A835U6V9_VANPL
152
0
16941
TrEMBL
other Location (Reliability: 4)
A0A5P8H727_LYCRD
239
0
27100
TrEMBL
other Location (Reliability: 2)
A0A4D5YH13_9ASPA
239
0
27156
TrEMBL
other Location (Reliability: 2)
A0A835PEL7_VANPL
248
0
27957
TrEMBL
other Location (Reliability: 4)
A0A2I0WIV6_9ASPA
238
0
26905
TrEMBL
other Location (Reliability: 3)
A0A2I0XJ94_9ASPA
239
0
27050
TrEMBL
other Location (Reliability: 2)
A0A5P1FGQ1_ASPOF
196
0
21832
TrEMBL
other Location (Reliability: 3)
A0A5P1FGM9_ASPOF
245
0
27425
TrEMBL
Secretory Pathway (Reliability: 2)
A0A5P1FHP4_ASPOF
193
0
21498
TrEMBL
other Location (Reliability: 5)
A0A346TLF5_NARPA
239
0
27102
TrEMBL
other Location (Reliability: 2)
A0A835UGT0_VANPL
447
0
50507
TrEMBL
other Location (Reliability: 3)
A0A2I0XJ70_9ASPA
259
0
29287
TrEMBL
other Location (Reliability: 2)
A0A5P1FRA6_ASPOF
285
0
31413
TrEMBL
Chloroplast (Reliability: 2)
A0A2I0A7B9_9ASPA
256
0
28561
TrEMBL
other Location (Reliability: 4)
A0A835QFE6_VANPL
257
0
28783
TrEMBL
other Location (Reliability: 2)
A0A2I0A8D1_9ASPA
53
0
5663
TrEMBL
other Location (Reliability: 5)
A0A835QGY7_VANPL
263
0
29515
TrEMBL
other Location (Reliability: 3)
A0A835PWK7_VANPL
239
0
26968
TrEMBL
other Location (Reliability: 2)
A0A2I0WG85_9ASPA
285
0
31584
TrEMBL
Chloroplast (Reliability: 3)
A0A5P1FEF0_ASPOF
155
0
17107
TrEMBL
other Location (Reliability: 2)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Kilgore, M.B.; Augustin, M.M.; May, G.D.; Crow, J.A.; Kutchan, T.M.
CYP96T1 of Narcissus sp. aff. pseudonarcissus catalyzes formation of the para-para' C-C phenol couple in the Amaryllidaceae alkaloids
Front. Plant Sci.
7
225
2016
Galanthus elwesii, Galanthus sp., Narcissus aff. pseudonarcissus MK-2014 (A0A077EWA5)
brenda
Kilgore, M.B.; Kutchan, T.M.
The Amaryllidaceae alkaloids: biosynthesis and methods for enzyme discovery
Phytochem. Rev.
15
317-337
2016
Lycoris aurea, Narcissus aff. pseudonarcissus MK-2014 (A0A077EWA5)
brenda
Kilgore, M.B.; Augustin, M.M.; Starks, C.M.; ONeil-Johnson, M.; May, G.D.; Crow, J.A.; Kutchan, T.M.
Cloning and characterization of a norbelladine 4-O-methyltransferase involved in the biosynthesis of the Alzheimers drug galanthamine in Narcissus sp. aff. pseudonarcissus
PLoS ONE
9
e103223
2014
Narcissus aff. pseudonarcissus MK-2014 (A0A077EWA5)
brenda
Li, W.; Qiao, C.; Pang, J.; Zhang, G.; Luo, Y.
The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in amaryllidaceae alkaloids biosynthesis
Int. J. Biol. Macromol.
141
680-692
2019
Lycoris radiata (A0A5C2H154), Lycoris radiata
brenda
Sun, B.; Wang, P.; Wang, R.; Li, Y.; Xu, S.
Molecular Cloning and Characterization of a meta/para-O-Methyltransferase from Lycoris aurea
Int. J. Mol. Sci.
19
1911
2018
Lycoris aurea
brenda
Reis, A.; Magne, K.; Massot, S.; Tallini, L.R.; Scopel, M.; Bastida, J.; Ratet, P.; Zuanazzi, J.A.S.
Amaryllidaceae alkaloids identification and partial characterization of montanine production in Rhodophiala bifida plant
Sci. Rep.
9
8471
2019
Zephyranthes bifida (A0A4D5YH13), Zephyranthes bifida
brenda