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Information on EC 2.1.1.297 - peptide chain release factor N5-glutamine methyltransferase

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EC Tree
IUBMB Comments
Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[peptide chain release factor 1 or 2]-L-glutamine
=
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[peptide chain release factor 1 or 2]-N5-methyl-L-glutamine
Synonyms
hemk2, hemk1, n5-glutamine methyltransferase, prmc/hemk, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine
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