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2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
2 nitric oxide + 2 reduced bovine heart cytochrome c + 2 H+
nitrous oxide + 2 oxidized bovine heart cytochrome c + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
N2O + acceptor + H2O
NO + reduced acceptor
-
-
-
-
r
N2O + phenazine methosulfate + H2O
NO + reduced phenazine methosulfate
nitric oxide + ferrocytochrome c552
nitrous oxide + ferricytochrome c552 + H2O
Marinobacter nauticus
-
-
-
-
?
nitric oxide + NAD(P)H + H+
nitrous oxide + NAD(P)+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH
nitrous oxide + NAD+ + H2O
-
-
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
nitric oxide + oxidized acceptor + H+
nitrous oxide + reduced acceptor + H2O
-
-
-
-
?
nitric oxide + reduced acceptor
nitrous oxide + oxidized acceptor + H2O
nitric oxide + reduced ascorbate
nitrous oxide + oxidized ascorbate + H2O
Marinobacter nauticus
-
-
-
-
?
nitric oxide + reduced cytochrome c
nitrous oxide + cytochrome c + H2O
nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine
nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O
nitric oxide + reduced phenazine methosulfate
nitrous oxide + oxidized phenazine methosulfate + H2O
nitric oxide + reduced pseudoazurin
nitrous oxide + oxidized pseudoazurin + H2O
nitric oxide + reduced pseudoazurin
nitrous oxide + pseudoazurin + H2O
-
-
-
-
?
nitrous oxide + 2 ferricytochrome c + H2O
2 nitric oxide + 2 ferrocytochrome c + 2 H+
-
-
-
?
NO + 5-hydroxy-1,4-naphthoquinol
N2O + H2O + 5-hydroxy-1,4-naphthoquinone
-
-
-
-
?
NO + 5-hydroxy-2-methyl-1,4-naphthoquinol
N2O + H2O + 5-hydroxy-2-methyl-1,4-naphthoquinone
-
-
-
-
?
NO + menaquinol
N2O + H2O + menaquinone
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
NO + NADPH
N2O + H2O + NADP+
NO + reduced acceptor
N2O + H2O + acceptor
NO + reduced cytochrome c551
N2O + H2O + oxidized cytochrome c551
-
-
-
-
?
O2 + reduced acceptor + H+
H2O + oxidized acceptor
-
-
-
-
?
O2 + reduced cytochrome c
H2O + cytochrome c
-
-
-
-
?
additional information
?
-
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate and phenazine methosulfate, NADH, NADH/menadione, NADH/duroquinone, NADH/2,3-dimethoxy-5-methyl-1,4-benzoquinone and N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
To degrade NO, FlRd has to be reduced by NADH via the FAD-binding protein flavorubredoxin reductase. NADH, but not NADPH, quickly reduces the FlRd-reductase. The reductase in turn quickly reduces the rubredoxin (Rd) center of FlRd
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate/phenazine methosulfate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
395112, 395114, 395115, 395116, 395118, 395120, 395124, 395127, 395131, 395133, 395134, 395135, 395136, 395137, 395139, 395140, 395141, 671883, 671948, 671964, 672352, 674003 -
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
phenazine methosulfate and dithiothreitol as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NADH, succinate or ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors in membrane vesicles
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ferrocytochrome c-550 as electron donor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate/phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate, 2,3,5,6-tetramethyl-1,4-benzendiamine/ascorbate and NADH as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
investigation of proton and electron pathways, electron-transfer pathways are similar to those in oxygen-reducing heme-copper oxidases
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NADH, succinate or isoascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
isoascorbate/2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors and horse heart cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
mechanism
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
lactate, leuco-forms of thionine, brilliant cresyl blue and methylene blue as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate/phenazine methosulfate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
reduced menadione as electron donor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
N2O + phenazine methosulfate + H2O
NO + reduced phenazine methosulfate
-
using NO donor sodium nitroprusside and a N2 atmosphere in presence of NADH
-
-
r
N2O + phenazine methosulfate + H2O
NO + reduced phenazine methosulfate
-
-
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
-
-
-
-
r
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + reduced acceptor
nitrous oxide + oxidized acceptor + H2O
Marinobacter nauticus
-
-
-
-
?
nitric oxide + reduced acceptor
nitrous oxide + oxidized acceptor + H2O
-
-
-
-
?
nitric oxide + reduced acceptor
nitrous oxide + oxidized acceptor + H2O
-
-
-
-
?
nitric oxide + reduced cytochrome c
nitrous oxide + cytochrome c + H2O
-
-
-
-
?
nitric oxide + reduced cytochrome c
nitrous oxide + cytochrome c + H2O
-
-
-
-
?
nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine
nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O
-
-
-
-
?
nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine
nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O
-
-
-
-
?
nitric oxide + reduced phenazine methosulfate
nitrous oxide + oxidized phenazine methosulfate + H2O
-
-
-
-
?
nitric oxide + reduced phenazine methosulfate
nitrous oxide + oxidized phenazine methosulfate + H2O
-
-
-
-
?
nitric oxide + reduced pseudoazurin
nitrous oxide + oxidized pseudoazurin + H2O
-
-
-
-
?
nitric oxide + reduced pseudoazurin
nitrous oxide + oxidized pseudoazurin + H2O
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
?
NO + NADH
N2O + H2O + NAD+
NADH is preferred over NADPH
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
NADH is preferred over NADPH
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
very little activity with NADPH
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
very little activity with NADPH
-
-
?
NO + NADPH
N2O + H2O + NADP+
-
-
-
?
NO + NADPH
N2O + H2O + NADP+
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
FlRd may protect Escherichia coli against NO, catalyzing the anaerobic reduction of NO to N2O
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
additional information
?
-
-
both toxin Dtx and nitric oxide reductase are the two key players required for survival and pathogenesis of Corynebacterium diphtheriae, their expressions being controlled by two independent regulators DtxR and DIP1512 respectively. The controlling system appears to be decoupled because of differential affinities of the two regulators for NO
-
-
?
additional information
?
-
NO reduction takes place in the NorB subunit that contains three redox centers: two b-type hemes (hemes b and b3) and a non-heme iron (FeB). Heme b3 and the non-heme iron form the binuclear center, where nitric oxide is bound and reduced. Determination of reduction rates of the cNOR variants with O2 and NO
-
-
?
additional information
?
-
-
NO reduction takes place in the NorB subunit that contains three redox centers: two b-type hemes (hemes b and b3) and a non-heme iron (FeB). Heme b3 and the non-heme iron form the binuclear center, where nitric oxide is bound and reduced. Determination of reduction rates of the cNOR variants with O2 and NO
-
-
?
additional information
?
-
-
Pseudomonas aeruginosa NO reductase may contribute to the intracellular survival by acting as a counter component against the hosts defense systems
-
-
?
additional information
?
-
-
the dissimilative nitrate respiration regulator DNR is involved in transcription regulation of the enzyme, apo-DNR binds heme in vitro and the heme-bound form reacts with carbon monoxide and NO, thus supporting the hypothesis that NO sensing involves gas binding to the ferrous heme, mechanism and structure, overview
-
-
?
additional information
?
-
all-atom molecular dynamics simulations within an explicit membrane/solvent environment reveal two possible proton transfer pathways leading from the periplasm to the active site, while no pathways from the cytoplasmic side are found, consistently with the experimental observations that the enzyme is not a proton pump. One of the pathways is blocked in the crystal structure and requires small structural rearrangements to allow for water channel formation. That pathway is equivalent to the functional periplasmic cavity postulated in cbb3 oxidase
-
-
?
additional information
?
-
-
quantumchemical calculations show that the reduction of the NO molecules by the enzyme and the formation of N2O are very exergonic steps, making the rereduction of the enzyme endergonic and rate-limiting for the entire catalytic cycle. Therefore the NO reduction cannot be electrogenic, i.e. cannot take electrons and protons from the opposite sides of the membrane, since it would increase the endergonicity of the rereduction when the gradient is present, thereby increasing the rate-limiting barrier, and the reaction would become too slow. It also means that proton pumping coupled to electron transfer is not possible in cytochrome c-dependent nitric oxide reductase
-
-
?
additional information
?
-
all-atom molecular dynamics simulations within an explicit membrane/solvent environment reveal two possible proton transfer pathways leading from the periplasm to the active site, while no pathways from the cytoplasmic side are found, consistently with the experimental observations that the enzyme is not a proton pump. One of the pathways is blocked in the crystal structure and requires small structural rearrangements to allow for water channel formation. That pathway is equivalent to the functional periplasmic cavity postulated in cbb3 oxidase
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
N2O + acceptor + H2O
NO + reduced acceptor
-
-
-
-
r
nitric oxide + NAD(P)H + H+
nitrous oxide + NAD(P)+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
nitric oxide + reduced pseudoazurin
nitrous oxide + pseudoazurin + H2O
-
-
-
-
?
nitrous oxide + 2 ferricytochrome c + H2O
2 nitric oxide + 2 ferrocytochrome c + 2 H+
-
-
-
?
NO + NADH
N2O + H2O + NAD+
NO + NADPH
N2O + H2O + NADP+
NO + reduced acceptor
N2O + H2O + acceptor
additional information
?
-
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
To degrade NO, FlRd has to be reduced by NADH via the FAD-binding protein flavorubredoxin reductase. NADH, but not NADPH, quickly reduces the FlRd-reductase. The reductase in turn quickly reduces the rubredoxin (Rd) center of FlRd
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
395112, 395115, 395116, 395118, 395120, 395124, 395127, 395131, 395133, 395134, 395135, 395136, 395137, 395139, 395140, 395141 -
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADH
N2O + H2O + NAD+
-
-
-
-
?
NO + NADPH
N2O + H2O + NADP+
-
-
-
?
NO + NADPH
N2O + H2O + NADP+
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
FlRd may protect Escherichia coli against NO, catalyzing the anaerobic reduction of NO to N2O
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
NO + reduced acceptor
N2O + H2O + acceptor
-
-
-
-
?
additional information
?
-
-
both toxin Dtx and nitric oxide reductase are the two key players required for survival and pathogenesis of Corynebacterium diphtheriae, their expressions being controlled by two independent regulators DtxR and DIP1512 respectively. The controlling system appears to be decoupled because of differential affinities of the two regulators for NO
-
-
?
additional information
?
-
-
Pseudomonas aeruginosa NO reductase may contribute to the intracellular survival by acting as a counter component against the hosts defense systems
-
-
?
additional information
?
-
-
the dissimilative nitrate respiration regulator DNR is involved in transcription regulation of the enzyme, apo-DNR binds heme in vitro and the heme-bound form reacts with carbon monoxide and NO, thus supporting the hypothesis that NO sensing involves gas binding to the ferrous heme, mechanism and structure, overview
-
-
?
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Fusarium oxysporum
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Fusarium oxysporum
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Purification and initial kinetic and spectroscopic characterization of NO reductase from Paracoccus denitrificans
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brenda
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Functional and structural comparison of nitric oxide reductases from denitrifying fungi Cylindrocarpon tonkinense and Fusarium oxysporum
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Fusarium lichenicola, Fusarium oxysporum
brenda
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Isolation and characterization of nitric oxide reductase from Paracoccus halodenitrificans
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Paracoccus denitrificans
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-
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-
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111-119
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Proton transfer in bacterial nitric oxide reductase
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Reduction of nitric oxide in bacterial nitric oxide reductase--a theoretical model study
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Gene structure and expression profile of cytochrome bc nitric oxide reductase from Hydrogenobacter thermophilus TK-6
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Paracoccus denitrificans
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188
7344-7353
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27
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Fusarium oxysporum
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Nitric oxide reductases of prokaryotes with emphasis on the respiratory, heme-copper oxidase type
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194-215
2005
Achromobacter cycloclastes, Alcaligenes faecalis, Alcaligenes faecalis S-6, Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110, Brucella melitensis, Burkholderia mallei, Burkholderia pseudomallei, Burkholderia pseudomallei K96243, Cereibacter sphaeroides, Chromobacterium violaceum, Chromobacterium violaceum ATCC 12472, Colwellia psychrerythraea, Corynebacterium diphtheriae, Corynebacterium diphtheriae NCTC13129, Cupriavidus metallidurans, Cupriavidus metallidurans CH34, Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1, Desulfitobacterium hafniense, Desulfitobacterium hafniense DCB-2, Escherichia coli, Geobacillus stearothermophilus, Geobacillus stearothermophilus 10, Geobacter metallireducens, Geobacter metallireducens GS-15 / ATCC 53774 / DSM 7210, Halomonas halodenitrificans, Legionella pneumophila, Legionella pneumophila Philadelphia-1, Magnetococcus sp., Magnetococcus sp. mc-1, Methylococcus capsulatus, Mycobacterium avium, Mycobacterium avium 104, Neisseria meningitidis, Neisseria meningitidis MC58, Nitrosomonas europaea, Paracoccus denitrificans, Paracoccus denitrificans Pd 1222, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens C7R12, Pseudomonas sp., Pseudomonas sp. G-179, Pseudomonas stutzeri, Pyrobaculum aerophilum, Pyrobaculum aerophilum IM2, Ralstonia solanacearum, Rhodopseudomonas palustris, Roseobacter denitrificans, Ruegeria pomeroyi, Saccharolobus solfataricus, Saccharolobus solfataricus P2, Sinorhizobium meliloti, Staphylococcus aureus, Staphylococcus aureus EMRSA-16, Synechocystis sp.
brenda
Kakishima, K.; Shiratsuchi, A.; Taoka, A.; Nakanishi, Y.; Fukumori, Y.
Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages
Biochem. Biophys. Res. Commun.
355
587-591
2007
Pseudomonas aeruginosa
brenda
Kapetanaki, S.M.; Field, S.J.; Hughes, R.J.; Watmough, N.J.; Liebl, U.; Vos, M.H.
Ultrafast ligand binding dynamics in the active site of native bacterial nitric oxide reductase
Biochim. Biophys. Acta
1777
919-924
2008
Paracoccus denitrificans
brenda
Vicente, J.B.; Scandurra, F.M.; Rodrigues, J.V.; Brunori, M.; Sarti, P.; Teixeira, M.; Giuffre, A.
Kinetics of electron transfer from NADH to the Escherichia coli nitric oxide reductase flavorubredoxin
FEBS J.
274
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2007
Escherichia coli
brenda
Gupta, S.; Bansal, S.; Deb, J.K.; Kundu, B.
Interplay between DtxR and nitric oxide reductase activities: a functional genomics approach indicating involvement of homologous protein domains in bacterial pathogenesis
Int. J. Exp. Pathol.
88
377-385
2007
Corynebacterium diphtheriae
brenda
Zhang, L.; Shoun, H.
Purification and functional analysis of fungal nitric oxide reductase cytochrome P450nor
Methods Enzymol.
437
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2008
Fusarium oxysporum (P23295), Fusarium lichenicola (Q00616), Fusarium lichenicola (Q12599), Aspergillus oryzae (Q8NKB4), Cutaneotrichosporon cutaneum (Q96WS9)
brenda
Vicente, J.B.; Scandurra, F.M.; Forte, E.; Brunori, M.; Sarti, P.; Teixeira, M.; Giuffre, A.
Kinetic characterization of the Escherichia coli nitric oxide reductase flavorubredoxin
Methods Enzymol.
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47-62
2008
Escherichia coli
brenda
Toyofuku, M.; Nomura, N.; Kuno, E.; Tashiro, Y.; Nakajima, T.; Uchiyama, H.
Influence of the Pseudomonas Quinolone Signal on Denitrification in Pseudomonas aeruginosa
J. Bacteriol.
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7947-7956
2008
Pseudomonas aeruginosa
brenda
Giardina, G.; Rinaldo, S.; Johnson, K.A.; Di Matteo, A.; Brunori, M.; Cutruzzolà, F.
NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR
J. Mol. Biol.
378
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2008
Pseudomonas aeruginosa
brenda
Matsuda, Y.; Inamori, K.; Osaki, T.; Eguchi, A.; Watanabe, A.; Kawabata, S.; Iba, K.; Arata, H.
Nitric oxide-reductase homologue that contains a copper atom and has cytochrome c-oxidase activity from an aerobic phototrophic bacterium Roseobacter denitrificans
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2002
Roseobacter denitrificans
brenda
Flock, U.; Lachmann, P.; Reimann, J.; Watmough, N.J.; Adelroth, P.
Exploring the terminal region of the proton pathway in the bacterial nitric oxide reductase
J. Inorg. Biochem.
103
845-850
2009
Paracoccus denitrificans
brenda
Field, S.J.; Thorndycroft, F.H.; Matorin, A.D.; Richardson, D.J.; Watmough, N.J.
The respiratory nitric oxide reductase (NorBC) from Paracoccus denitrificans
Methods Enzymol.
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2008
Paracoccus denitrificans, Paracoccus denitrificans 93.11
brenda
Isabella, V.; Wright, L.F.; Barth, K.; Spence, J.M.; Grogan, S.; Genco, C.A.; Clark, V.L.
cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae
Microbiology
154
226-239
2008
Neisseria gonorrhoeae, Neisseria gonorrhoeae F62
brenda
Conrath, K.; Pereira, A.S.; Martins, C.E.; Timoteo, C.G.; Tavares, P.; Spinelli, S.; Kinne, J.; Flaudrops, C.; Cambillau, C.; Muyldermans, S.; Moura, I.; Moura, J.J.; Tegoni, M.; Desmyter, A.
Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase
Protein Sci.
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2009
Marinobacter nauticus
brenda
Blomberg, M.R.; Siegbahn, P.E.
Why is the reduction of NO in cytochrome c dependent nitric oxide reductase (cNOR) not electrogenic?
Biochim. Biophys. Acta
1827
826-833
2013
Pseudomonas aeruginosa
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Pisliakov, A.; Hino, T.; Shiro, Y.; Sugita, Y.
Molecular dynamics simulations reveal proton transfer pathways in cytochrome C-dependent nitric oxide reductase
PLoS Comput. Biol.
8
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2012
Pseudomonas aeruginosa (Q59646), Pseudomonas aeruginosa ATCC 15692 (Q59646)
brenda
Bricio, C.; Alvarez, L.; San Martin, M.; Schurig-Briccio, L.A.; Gennis, R.B.; Berenguer, J.
A third subunit in ancestral cytochrome c-dependent nitric oxide reductases
Appl. Environ. Microbiol.
80
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2014
Thermus thermophilus (D5GU62 AND D5GU63), Thermus thermophilus, Thermus thermophilus PRQ25 (D5GU62 AND D5GU63)
brenda
Tosha, T.; Shiro, Y.
Crystal structures of nitric oxide reductases provide key insights into functional conversion of respiratory enzymes
IUBMB Life
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217-226
2013
Pseudomonas aeruginosa (Q59647 AND Q59646)
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ter Beek, J.; Krause, N.; Reimann, J.; Lachmann, P.; Aedelroth, P.
The nitric-oxide reductase from Paracoccus denitrificans uses a single specific proton pathway
J. Biol. Chem.
288
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2013
Paracoccus denitrificans (Q51662), Paracoccus denitrificans
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Blomberg, M.R.; Siegbahn, P.E.
Improved free energy profile for reduction of NO in cytochrome c dependent nitric oxide reductase (cNOR)
J. Comput. Chem.
37
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2016
Pseudomonas aeruginosa
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Sakurai, N.; Kataoka, K.; Sugaya, N.; Shimodaira, T.; Iwamoto, M.; Shoda, M.; Horiuchi, H.; Kiyono, M.; Ohta, Y.; Triwiyono, B.; Seo, D.; Sakurai, T.
Heterologous expression of Halomonas halodenitrificans nitric oxide reductase and its N-terminally truncated NorC subunit in Escherichia coli
J. Inorg. Biochem.
169
61-67
2017
Halomonas halodenitrificans (O50651), Halomonas halodenitrificans
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Kashyap, S.; Holden, J.F.
Microbe-mineral interaction and novel proteins for iron oxide mineral reduction in the hyperthermophilic crenarchaeon Pyrodictium delaneyi
Appl. Environ. Microbiol.
87
e02330-20
2021
Pyrodictium delaneyi (A0A0N7JD68), Pyrodictium delaneyi, Pyrodictium delaneyi Su06 (A0A0N7JD68)
brenda
Blomberg, M.
Can reduction of NO to N2O in cytochrome c dependent nitric oxide reductase proceed through a trans-mechanism?
Biochemistry
56
120-131
2017
Pseudomonas aeruginosa
brenda
Blomberg, M.R.A.; Aedelroth, P.
The mechanism for oxygen reduction in cytochrome c dependent nitric oxide reductase (cNOR) as obtained from a combination of theoretical and experimental results
Biochim. Biophys. Acta Bioenerg.
1858
884-894
2017
Paracoccus denitrificans
brenda
Blomberg, M.R.A.; Aedelroth, P.
Mechanisms for enzymatic reduction of nitric oxide to nitrous oxide - A comparison between nitric oxide reductase and cytochrome c oxidase
Biochim. Biophys. Acta Bioenerg.
1859
1223-1234
2018
Pseudomonas aeruginosa
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Kahle, M.; Blomberg, M.R.A.; Jareck, S.; Aedelroth, P.
Insights into the mechanism of nitric oxide reductase from a FeB-depleted variant
FEBS Lett.
593
1351-1359
2019
Paracoccus denitrificans
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