Disease on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)
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Aberrant Crypt Foci
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats.
Aberrant Crypt Foci
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Acute Lung Injury
ASSOCIATION OF HUMAN NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1) POLYMORPHISM WITH DEVELOPMENT OF ACUTE LUNG INJURY.
Adenocarcinoma
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
Adenocarcinoma
Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract.
Adenocarcinoma
C609T polymorphism of the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinoma.
Adenocarcinoma
Chemopreventive effect of protein extract of Asterina pectinifera in HT-29 human colon adenocarcinoma cells.
Adenocarcinoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Adenocarcinoma
Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.
Adenocarcinoma
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Adenocarcinoma
Enzymorphology of adenocarcinoma of the endometrium; beta-glucuronidase, acid phosphatase, reduced diphosphopyridine nucleotide (DPNH) diaphorase, and alpha-naphthyl esterase.
Adenocarcinoma
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Adenocarcinoma
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Adenocarcinoma
Identification of a methylcholanthrene-induced aldehyde dehydrogenase in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
Adenocarcinoma
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A Potential biomarker of early damage in the pancreas.
Adenocarcinoma
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas.
Adenocarcinoma
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by ?-lapachone.
Adenocarcinoma
The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.
Adenocarcinoma
The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
Adenoma
A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.
Adenoma
Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risks of Colorectal Adenoma and Cancer for Caucasians: A Meta-analysis.
Adenoma
miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.
Adenoma, Pleomorphic
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Alzheimer Disease
Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.
Alzheimer Disease
Association of NAD(P)H:Quinone Oxidoreductase 1 Polymorphism and Alzheimer's Disease in Chinese.
Alzheimer Disease
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
Alzheimer Disease
E3 Ligase STUB1/CHIP Regulates NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Accumulation in Aged Brain, a Process Impaired in Certain Alzheimer Disease Patients.
Alzheimer Disease
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.
Alzheimer Disease
[Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease]
Anemia, Hemolytic
Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo.
Anemia, Hemolytic
Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats.
Anemia, Hemolytic
Effects of modulation of tissue activities of DT-diaphorase on the toxicity of 2,3-dimethyl-1,4-naphthoquinone to rats.
Anemia, Iron-Deficiency
Methaemoglobin diaphorase of human erythrocytes in iron-deficiency anaemia.
Ascorbic Acid Deficiency
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
Asthma
NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma.
Asthma
Opposing effects of nasal epithelial NAD(P)H dehydrogenase quinine 1 and heme oxygenase 1 expression on upper and lower airway symptoms in adolescents with asthma.
Asthma
PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model.
Avitaminosis
Activity of xenobiotic-metabolizing enzymes in the liver of rats with multi-vitamin deficiency.
Barrett Esophagus
The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.
Brain Contusion
[Histochemical determination of date of cortical contusion - studies of changes in NADP diaphorase, glycero-3-PH-dehydrogenase, glucose-6-PH-DH and naphtylacetate-esterase]
Brain Ischemia
The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia.
Breast Neoplasms
DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.
Breast Neoplasms
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Breast Neoplasms
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Breast Neoplasms
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
Breast Neoplasms
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours.
Breast Neoplasms
Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.
Breast Neoplasms
Estrogen receptors: selective ligands, partners, and distinctive pharmacology.
Breast Neoplasms
gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells.
Breast Neoplasms
Histopathological effect of radiofrequency ablation therapy for primary breast cancer, with special reference to changes in cancer cells and stromal structure and a comparison with enzyme histochemistry.
Breast Neoplasms
Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin.
Breast Neoplasms
Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.
Breast Neoplasms
Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen.
Breast Neoplasms
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.
Breast Neoplasms
NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
Breast Neoplasms
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
Breast Neoplasms
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
Breast Neoplasms
Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones.
Breast Neoplasms
Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.
Breast Neoplasms
Significance of genetic variation at the glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancer development.
Breast Neoplasms
The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Breast Neoplasms
Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.
Bronchitis
[The NADPH-diaphorase activity of the bronchial epithelium in chronic lung diseases]
Bronchopulmonary Dysplasia
Association of C609T-Inborn Polymorphism of NAD(P)H: Quinone Oxidoreductase 1 with the Risk of Bronchopulmonary Dysplasia in Preterm Neonates.
Burkitt Lymphoma
NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines.
Carcinogenesis
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
Carcinogenesis
A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue.
Carcinogenesis
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis.
Carcinogenesis
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+).
Carcinogenesis
Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues.
Carcinogenesis
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Carcinogenesis
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Carcinogenesis
Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor.
Carcinogenesis
Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Carcinogenesis
Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis.
Carcinogenesis
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Carcinogenesis
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
Carcinogenesis
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Carcinogenesis
Dietary glucosinolates as blocking agents against carcinogenesis: glucosinolate breakdown products assessed by induction of quinone reductase activity in murine hepa1c1c7 cells.
Carcinogenesis
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells.
Carcinogenesis
Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
Carcinogenesis
Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans.
Carcinogenesis
Effects of psoralen from Psoralea corylifolia on quinone reductase, ornithine decarboxylase, and JB6 cells transformation promotion.
Carcinogenesis
Enhanced quinone reductase (QR) activity correlates with promotion potential of diethyl maleate (DEM) in rat forestomach and glandular stomach carcinogenesis initiated with N-methyl-N'-nitrosoguanidine (MNNG).
Carcinogenesis
Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity: implications for carcinogenesis.
Carcinogenesis
Improving the NQO1-Inducing Activities of Phenolic Acids from Radix Salvia miltiorrhiza: a Methylation Strategy.
Carcinogenesis
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
Carcinogenesis
Induction of NAD(P)H:quinone reductase by probucol: a possible mechanism for protection against chemical carcinogenesis and toxicity.
Carcinogenesis
Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis.
Carcinogenesis
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.
Carcinogenesis
Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice.
Carcinogenesis
Modifications of 3'-methyl-4-dimethylaminoazobenzene carcinogenesis of rat liver and carcinogen metabolism by portacaval anastomosis.
Carcinogenesis
Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Carcinogenesis
Mouse strain variations in the magnitude of induction of liver DT-diaphorase and hereditary transmission of the trait.
Carcinogenesis
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
Carcinogenesis
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
Carcinogenesis
New hits as phase II enzymes inducers from a focused library with heteroatom-heteroatom and Michael-acceptor motives.
Carcinogenesis
Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis.
Carcinogenesis
Nuclear factor E2-related factor 2-mediated induction of NAD(P)H:quinone oxidoreductase 1 by 3,5-dimethoxy-trans-stilbene.
Carcinogenesis
Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
Carcinogenesis
Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase.
Carcinogenesis
Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis.
Carcinogenesis
Rat strain variations in liver cytosolic DT-diaphorase activity and possible significance of the trait in carcinogenesis by azo dyes.
Carcinogenesis
Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer.
Carcinogenesis
Some acute effects of monochromatic ultraviolet B irradiation on mouse epidermis measured by the tetrazolium-reduction test and determination of DT-diaphorase activity, with reference to carcinogenesis.
Carcinogenesis
The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters.
Carcinogenesis
Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity.
Carcinogenesis
Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position 609.
Carcinogenesis
[Azoreductase in neoplastic liver tissue. II. Variations during oncogenesis and the effect of treatment with flavin.]
Carcinoma
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa.
Carcinoma
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Carcinoma
Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.
Carcinoma
Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas.
Carcinoma
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Carcinoma
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinoma
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
Carcinoma
Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colonic carcinomas.
Carcinoma
Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
Carcinoma
Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: Promotion of cytotoxic response to mitomycin C and fluorouracil.
Carcinoma
Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
Carcinoma
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Carcinoma
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Carcinoma
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
Carcinoma
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Carcinoma
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Carcinoma
Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells.
Carcinoma
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin CÅ.
Carcinoma
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Carcinoma
Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines.
Carcinoma
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Carcinoma
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Carcinoma
Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
Carcinoma
Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line.
Carcinoma
Mapping of DNA alkylation sites induced by aziridinylbenzoquinones in human cells by ligation-mediated polymerase chain reaction.
Carcinoma
Mesoporous Silica Nanoparticle-Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC).
Carcinoma
Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Carcinoma
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Carcinoma
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
Carcinoma
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
Carcinoma
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Carcinoma
Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and beta-lapachone combination treatment.
Carcinoma
Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line.
Carcinoma
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C.
Carcinoma
Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin.
Carcinoma
Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Carcinoma
Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus.
Carcinoma
The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)
Carcinoma
The NAD(P)H:quinone oxidoreductase locus in human colon carcinoma HCT 116 cells resistant to mitomycin C.
Carcinoma
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Carcinoma
The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells.
Carcinoma
[Histoenzymatic studies of cervical carcinoma. II. Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, TPN diaphorase and DPN diaphorase]
Carcinoma
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Carcinoma, Basal Cell
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinoma, Hepatocellular
1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells.
Carcinoma, Hepatocellular
2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance.
Carcinoma, Hepatocellular
7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes.
Carcinoma, Hepatocellular
?-Carboline Derivatives and Diphenols from Soy Sauce Are in Vitro Quinone Reductase (QR) Inducers.
Carcinoma, Hepatocellular
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Carcinoma, Hepatocellular
A tissue homogenate method to prepare gram-scale allium thiosulfinates and their disulfide conjugates with cysteine and glutathione.
Carcinoma, Hepatocellular
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Carcinoma, Hepatocellular
Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
Carcinoma, Hepatocellular
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
Carcinoma, Hepatocellular
An histochemical investigation of diaphorase and succine dehydrogenase in induced and transplanted hepatomas.
Carcinoma, Hepatocellular
Anti-carcinogenic activity of 6-methylsulfinylhexyl isothiocyanate-, an active anti-proliferative principal of wasabi (Eutrema wasabi Maxim.).
Carcinoma, Hepatocellular
Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract.
Carcinoma, Hepatocellular
Antioxidant and Quinone Reductase Activity of Soyasaponins in Hepa1c1c7 Mouse Hepatocarcinoma Cells.
Carcinoma, Hepatocellular
Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides.
Carcinoma, Hepatocellular
Aqueous extract from Spanish black radish (Raphanus sativus L. Var. niger) induces detoxification enzymes in the HepG2 human hepatoma cell line.
Carcinoma, Hepatocellular
Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity.
Carcinoma, Hepatocellular
Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways.
Carcinoma, Hepatocellular
Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Carcinoma, Hepatocellular
Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines.
Carcinoma, Hepatocellular
Chemical and molecular regulation of enzymes that detoxify carcinogens.
Carcinoma, Hepatocellular
Chemical structures critical for the induction of FMN-dependent NADH-quinone reductase in Escherichia coli.
Carcinoma, Hepatocellular
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE).
Carcinoma, Hepatocellular
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.
Carcinoma, Hepatocellular
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
Carcinoma, Hepatocellular
Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model.
Carcinoma, Hepatocellular
Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.
Carcinoma, Hepatocellular
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Carcinoma, Hepatocellular
Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities.
Carcinoma, Hepatocellular
Cytosolic activation of aromatic and heterocyclic amines. Inhibition by dicoumarol and enhancement in viral hepatitis B.
Carcinoma, Hepatocellular
Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes.
Carcinoma, Hepatocellular
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s.
Carcinoma, Hepatocellular
Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Differential effects of vegetable-derived indoles on the induction of quinone reductase in hepatoma cells.
Carcinoma, Hepatocellular
Effects of the administration of anticoagulants on the activity of the enzyme-reduced NAD(P)H dehydrogenase in rat livers, hepatomas and precarcinomatous rat liver lesions.
Carcinoma, Hepatocellular
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Carcinoma, Hepatocellular
Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene.
Carcinoma, Hepatocellular
Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins.
Carcinoma, Hepatocellular
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Carcinoma, Hepatocellular
Functional detection of chemopreventive glucosinolates in Arabidopsis thaliana.
Carcinoma, Hepatocellular
Genotoxicity, cytotoxicity and chemical profile from Inga laurina (Fabaceae).
Carcinoma, Hepatocellular
Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals.
Carcinoma, Hepatocellular
Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identification of Chemopreventive Components from Halophytes Belonging to Aizoaceae and Cactaceae Through LC/MS-Bioassay Guided Approach.
Carcinoma, Hepatocellular
In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts.
Carcinoma, Hepatocellular
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
Carcinoma, Hepatocellular
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens.
Carcinoma, Hepatocellular
Induction of phase II enzyme activity by various selenium compounds.
Carcinoma, Hepatocellular
Induction of phase II enzyme, quinone reductase, in murine hepatoma cells in vitro by grape extracts and selected phytochemicals
Carcinoma, Hepatocellular
Induction of quinone reductase activity by stilbene analogs in mouse Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Induction of quinone reductase by allylisothiocyanate (AITC) and the N-acetylcysteine conjugate of AITC in Hepa1c1c7 mouse hepatoma cells.
Carcinoma, Hepatocellular
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Carcinoma, Hepatocellular
Induction of quinone reductase by withanolides isolated from Physalis philadelphica (tomatillos).
Carcinoma, Hepatocellular
Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells.
Carcinoma, Hepatocellular
Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids.
Carcinoma, Hepatocellular
Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines.
Carcinoma, Hepatocellular
Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.
Carcinoma, Hepatocellular
Isolation and identification of phase II enzyme inductors obtained from black Shawaya sorghum [Sorghum bicolor (L.) Moench] bran
Carcinoma, Hepatocellular
Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.).
Carcinoma, Hepatocellular
Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa).
Carcinoma, Hepatocellular
Isolation of quinone reductase (QR) inducing agents from ginger rhizome and their in vitro anti-inflammatory activity
Carcinoma, Hepatocellular
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells.
Carcinoma, Hepatocellular
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.
Carcinoma, Hepatocellular
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Carcinoma, Hepatocellular
Mechanisms of induction of enzymes that protect against chemical carcinogenesis.
Carcinoma, Hepatocellular
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.
Carcinoma, Hepatocellular
Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.
Carcinoma, Hepatocellular
Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
NAD(P)H : Quinone Oxidoreductase 1 Inducer Activity of Some Saudi Arabian Medicinal Plants.
Carcinoma, Hepatocellular
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Carcinoma, Hepatocellular
New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.
Carcinoma, Hepatocellular
New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Carcinoma, Hepatocellular
No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects.
Carcinoma, Hepatocellular
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Carcinoma, Hepatocellular
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress.
Carcinoma, Hepatocellular
Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae.
Carcinoma, Hepatocellular
On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.
Carcinoma, Hepatocellular
Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity.
Carcinoma, Hepatocellular
Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1? Pathway.
Carcinoma, Hepatocellular
Phase II enzyme induction and anti?inflammatory effects of crude extracts and secondary fractions obtained from bran from five black glutinous rice cultivars
Carcinoma, Hepatocellular
Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation.
Carcinoma, Hepatocellular
Phase II-Inducing, Polyphenols Content and Antioxidant Capacity of Corn (Zea mays L.) from Phenotypes of White, Blue, Red and Purple Colors Processed into Masa and Tortillas.
Carcinoma, Hepatocellular
Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.
Carcinoma, Hepatocellular
Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes.
Carcinoma, Hepatocellular
Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes.
Carcinoma, Hepatocellular
Polyozellin isolated from Polyozellus multiplex induces phase 2 enzymes in mouse hepatoma cells and differentiation in human myeloid leukaemic cell lines.
Carcinoma, Hepatocellular
Potential cancer chemopreventive constituents of the leaves of Macaranga triloba.
Carcinoma, Hepatocellular
Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
Carcinoma, Hepatocellular
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Carcinoma, Hepatocellular
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Rapid detection of inducers of enzymes that protect against carcinogens.
Carcinoma, Hepatocellular
Rat liver NAD(P)H: Quinone reductase. Regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene.
Carcinoma, Hepatocellular
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Carcinoma, Hepatocellular
Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.
Carcinoma, Hepatocellular
Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression.
Carcinoma, Hepatocellular
Role of catechin quinones in the induction of EpRE-mediated gene expression.
Carcinoma, Hepatocellular
Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants.
Carcinoma, Hepatocellular
Screening for Phase II Enzyme-inducing and Antioxidant Activities of Common Vegetables
Carcinoma, Hepatocellular
Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli.
Carcinoma, Hepatocellular
Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers.
Carcinoma, Hepatocellular
Sorghum 3-Deoxyanthocyanins Possess Strong Phase II Enzyme Inducer Activity and Cancer Cell Growth Inhibition Properties.
Carcinoma, Hepatocellular
Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.
Carcinoma, Hepatocellular
The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.
Carcinoma, Hepatocellular
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).
Carcinoma, Hepatocellular
The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)
Carcinoma, Hepatocellular
The electrophile counterattack response: protection against neoplasia and toxicity.
Carcinoma, Hepatocellular
The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations.
Carcinoma, Hepatocellular
The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines.
Carcinoma, Hepatocellular
The synergistic effect of cell wall extracted from probiotic biomass containing Lactobacillus acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2 on the anticancer activity of cranberry juice-HPLC fractions.
Carcinoma, Hepatocellular
Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements.
Carcinoma, Hepatocellular
[6]-Dehydroshogaol, a minor component in ginger rhizome, exhibits quinone reductase inducing and anti-inflammatory activities that rival those of curcumin
Carcinoma, Hepatocellular
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)]
Carcinoma, Hepatocellular
[Relationship between hepatocellular carcinoma and the interaction between NQO1 polymorphisms and environmental factors].
Carcinoma, Mucoepidermoid
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Carcinoma, Non-Small-Cell Lung
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Carcinoma, Non-Small-Cell Lung
Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts.
Carcinoma, Non-Small-Cell Lung
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Carcinoma, Non-Small-Cell Lung
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Carcinoma, Non-Small-Cell Lung
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Discovery of Non-Quinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin CÅ.
Carcinoma, Non-Small-Cell Lung
Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling.
Carcinoma, Non-Small-Cell Lung
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Carcinoma, Non-Small-Cell Lung
The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
The Role of NQO1 Polymorphisms in the Susceptibility and Chemotherapy Response of Chinese NSCLC Patients.
Carcinoma, Renal Cell
Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines.
Carcinoma, Small Cell
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Carcinoma, Squamous Cell
Mesoporous Silica Nanoparticle-Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC).
Cardiotoxicity
Lipid peroxidation and antioxidant defense mechanisms in rat renal tissue after daunorubicin administration.
Cardiotoxicity
The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity.
Cardiovascular Diseases
NAD(P)H:Quinone Oxidoreductase 1 and its Potential Protective Role in Cardiovascular Diseases and Related Conditions.
Chemical and Drug Induced Liver Injury
Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury.
Cholangiocarcinoma
Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.
Cholangiocarcinoma
Downregulation of NAD(P)H:quinone oxidoreductase 1 inhibits proliferation, cell cycle and migration of cholangiocarcinoma cells.
Cholangiocarcinoma
Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.
Cholangiocarcinoma
Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents.
Cholestasis
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
Colitis
Host nuclear factor erythroid 2-related factor-2 defense system determines the outcome of dextran sulfate sodium-induced colitis in mice.
Colitis
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
Colitis
Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis.
Colitis, Ulcerative
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
Colitis, Ulcerative
In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe.
Colitis, Ulcerative
Involvement of NAD(P)H:Quinone Oxidoreductase 1 and Superoxide Dismutase Polymorphisms in Ulcerative Colitis.
Colitis, Ulcerative
Ulcerative colitis-induced hepatic damage in mice: studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression.
Colonic Neoplasms
A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.
Colonic Neoplasms
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa.
Colonic Neoplasms
Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.
Colonic Neoplasms
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells.
Colonic Neoplasms
Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase.
Colonic Neoplasms
Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer.
Colonic Neoplasms
Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.
Colonic Neoplasms
Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.
Colonic Neoplasms
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Colonic Neoplasms
Induction of NAD(P)H:quinone reductase by vitamins A, E and C in Colo205 colon cancer cells.
Colonic Neoplasms
Interaction of heat and hypoxia in modulating transcription of DT diaphorase in human colon adenocarcinoma cells.
Colonic Neoplasms
NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells.
Colonic Neoplasms
NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
Colonic Neoplasms
NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia.
Colonic Neoplasms
Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation.
Colonic Neoplasms
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
Colonic Neoplasms
Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention.
Colonic Neoplasms
Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells.
Colonic Neoplasms
Sorghum 3-Deoxyanthocyanins Possess Strong Phase II Enzyme Inducer Activity and Cancer Cell Growth Inhibition Properties.
Colonic Neoplasms
The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines.
Colorectal Neoplasms
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Colorectal Neoplasms
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Colorectal Neoplasms
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
Colorectal Neoplasms
Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Colorectal Neoplasms
Design, Synthesis, Characterization, and Crystal Structure Studies of Nrf2 Modulators for Inhibiting Cancer Cell Growth In Vitro and In Vivo.
Colorectal Neoplasms
Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase.
Colorectal Neoplasms
Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response.
Colorectal Neoplasms
NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer.
Colorectal Neoplasms
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Colorectal Neoplasms
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population.
Colorectal Neoplasms
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Colorectal Neoplasms
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
Colorectal Neoplasms
The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.
Colorectal Neoplasms
The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
Contracture
The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium. III. The differential effect of papaverine and rotenone on DT diaphorase.
Crohn Disease
Bacterial enzymes used for colon-specific drug delivery are decreased in active Crohn's disease.
Cystitis, Interstitial
NAD(P)H:quinone oxidoreductase 1 protects bladder epithelium against painful bladder syndrome in mice.
Dehydration
Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes.
Diabetes Mellitus
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.
Diabetes Mellitus, Type 1
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Diabetes Mellitus, Type 2
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.
Diabetic Nephropathies
Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy.
Diabetic Nephropathies
The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization.
dihydrolipoyl dehydrogenase deficiency
Congenital methaemoglobinaemia due to NADH methaemoglobin reductase deficiency: successful treatment with oral riboflavin.
Down Syndrome
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Endometrial Neoplasms
A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1.
Endometrial Neoplasms
Erratum: A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1 [Corrigendum].
Enzootic Bovine Leukosis
Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.
Enzootic Bovine Leukosis
Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs.
Enzootic Bovine Leukosis
The toxicity of aromatic nitrocompounds to bovine leukemia virus-transformed fibroblasts: the role of single-electron reduction.
Esophageal Neoplasms
Correlation between NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and increased risk of esophageal cancer: evidence from a meta-analysis.
Esophageal Neoplasms
[Polymorphism of NAD(P)H dehydrogenase (quinone) 1 (NQO1) C 609 T and risk of esophageal neoplasm]
Esophageal Neoplasms
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Esophageal Squamous Cell Carcinoma
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Esophageal Squamous Cell Carcinoma
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Fetal Resorption
Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits.
Glioblastoma
2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1).
Glioblastoma
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.
Heart Diseases
Diaphorase deficiency methaemoglobinaemia mimicking cardiac disease in pregnancy.
Heart Diseases
Down-Regulation of Porcine Heart Diaphorase Reactivity by Trimanganese Hexakis(3,5-Diisopropylsalicylate), Mn(3)(3,5-DIPS)6, and Down-Regulation of Nitric Oxide Synthase Reactivity by Mn(3)(3,5-DIPS)(6) and Cu(II)(2)(3,5-DIPS)(4).
Heart Failure
Altered number of diaphorase (NOS) positive neurons in the hypothalamus of rats with heart failure.
Heart Failure
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Hematologic Neoplasms
Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.
Hemolytic-Uremic Syndrome
NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes.
Hepatitis A
Elevations of hepatic quinone reductase, glutathione, and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury.
Hepatitis B
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Hepatitis C
[The enzyme activity of neutrophils of blood in patients with chronic viral hepatitis C depending on gender characteristics].
Hepatitis, Chronic
Elevations of hepatic quinone reductase, glutathione, and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury.
Hepatoblastoma
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Huntington Disease
The effect of nitric oxide synthase inhibition on quinolinic acid toxicity in the rat striatum.
Hyperalgesia
The Inhibitory Effects of Slow-Releasing Hydrogen Sulfide Donors in the Mechanical Allodynia, Grip Strength Deficits, and Depressive-Like Behaviors Associated with Chronic Osteoarthritis Pain.
Hyperalgesia
Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain.
Hyperglycemia
Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation.
Hyperparathyroidism, Primary
Nitric Oxide Synthase in Human Parathyroid Glands and Parathyroid Adenomas.
Hypersensitivity
Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para-amino compounds.
Hypersensitivity
Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis.
Hypertension
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Hypertension
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Hypoprothrombinemias
Effect of N-methyltetrazolethiol on liver microsomal vitamin K reductase.
Hypoprothrombinemias
In vivo effects of beta-lactam antibiotics and heterocyclic thiol compounds on vitamin K-dependent carboxylation activity and blood coagulation factors in vitamin K-deficient rats.
Hypotension, Orthostatic
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Infections
Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches.
Infections
Combined therapy with chemotherapeutic agents and herpes simplex virus type 1 ICP34.5 mutant (HSV-1716) in human non-small cell lung cancer.
Infections
Differential regulation of wheat quinone reductases in response to powdery mildew infection.
Infections
Dying for Good: Virus-Bacterium Biofilm Co-evolution Enhances Environmental Fitness.
Infections
Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease.
Inflammatory Bowel Diseases
Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models.
Inflammatory Bowel Diseases
Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide.
Influenza, Human
Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D.
Insulin Resistance
The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction.
Intellectual Disability
Mental retardation in methemoglobinemia due to diaphorase deficiency.
Intestinal Diseases
In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe.
Ischemic Stroke
Association of cytochrome P4502E1 and NAD(P)H:quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case-control study in the Turkish population.
Kidney Diseases
Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions, and relation to morbidity.
Kidney Neoplasms
Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner.
Leiomyoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Leprosy
Carbohydrate metabolism of the murine leprosy bacillus. I. Studies on the respiratory enzyme system, especially the diaphorase and malic dehydrogenase activities.
Leukemia
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
Leukemia
Associations of NQO1 C609T and NQO1 C465T polymorphisms with acute leukemia risk: a PRISMA-compliant meta-analysis.
Leukemia
Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway.
Leukemia
Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells.
Leukemia
Detoxification ability and toxicity of quinones in mouse and human tumor cell lines used for anticancer drug screening.
Leukemia
Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity.
Leukemia
Hydroquinone resistance in a murine myeloblastic leukemia cell line. Involvement of quinone reductase and glutathione-dependent detoxification in nonclassical multidrug resistance.
Leukemia
Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia.
Leukemia
Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.
Leukemia
Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.
Leukemia
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
Leukemia
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Leukemia
NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia.
Leukemia
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
Leukemia
The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan.
Leukemia, Erythroblastic, Acute
Alterations in electrophoretic mobility, diaphorase activity, and terminal differentiation induced in murine erythroleukemia lines by differentiating agents.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.
Leukemia, Myeloid
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Leukemia, Myeloid, Acute
Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy.
Leukemia, Myeloid, Acute
The frequencies of NAD(P)H quinone oxidoreductase (NQO1) variant allele in Israeli ethnic groups and the relationship of NQO1*2 to adult acute myeloid leukemia in Israeli patients.
Liver Cirrhosis, Biliary
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.
Liver Diseases
Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease.
Liver Diseases
The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction.
Liver Neoplasms
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Liver Neoplasms
Effects of the administration of anticoagulants on the activity of the enzyme-reduced NAD(P)H dehydrogenase in rat livers, hepatomas and precarcinomatous rat liver lesions.
Liver Neoplasms
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells.
Liver Neoplasms
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Liver Neoplasms
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Liver Neoplasms, Experimental
Experimental hepatomas: dehydrogenation of reduced pyridine nucleotides by the D-T diaphorase.
Lung Injury
Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice.
Lung Injury
NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.
Lung Injury
Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD).
Lung Neoplasms
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Lung Neoplasms
Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts.
Lung Neoplasms
Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan.
Lung Neoplasms
Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression.
Lung Neoplasms
Association of the NAD(P)H:quinone oxidoreductase (NQO1) 609C->T polymorphism with lung cancer risk among male smokers.
Lung Neoplasms
Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.
Lung Neoplasms
Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity.
Lung Neoplasms
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Lung Neoplasms
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Lung Neoplasms
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Lung Neoplasms
Discovery of Non-Quinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small Cell Lung Cancer.
Lung Neoplasms
Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Lung Neoplasms
Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling.
Lung Neoplasms
Evaluation of the risk of lung cancer associated with NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism in male current cigarette smokers from the Eastern India.
Lung Neoplasms
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Lung Neoplasms
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
Lung Neoplasms
Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China.
Lung Neoplasms
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.
Lung Neoplasms
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Lung Neoplasms
Lack of association between NADPH quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer: a case-control study and a meta-analysis.
Lung Neoplasms
Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism.
Lung Neoplasms
Modulation of Nad(P)H:quinone oxidoreductase (NQO1) activity mediated by 5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential.
Lung Neoplasms
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis.
Lung Neoplasms
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Lung Neoplasms
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and the risk of lung cancer: A meta-analysis.
Lung Neoplasms
NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.
Lung Neoplasms
Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.
Lung Neoplasms
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Lung Neoplasms
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Lung Neoplasms
Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals.
Lung Neoplasms
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
Lung Neoplasms
Sulindac compounds facilitate the cytotoxicity of ?-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.
Lung Neoplasms
The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.
Lung Neoplasms
The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior.
Lung Neoplasms
The Role of NQO1 Polymorphisms in the Susceptibility and Chemotherapy Response of Chinese NSCLC Patients.
Lymphoma
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
Lymphoma
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.
Lymphoma
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Lymphoma, Non-Hodgkin
Role of the naphthoquinone moiety in the biological activities of sakyomicin A.
Malaria
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
Malaria
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2).
Malaria
Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.
Manganese Poisoning
Dihydronicotinamide-adenine dinucleotide (NADH2) diaphorase, thiamine pyrophosphatase and acid phosphatase in the spinal cords of rabbits with chronic manganese poisoning.
Melanoma
17-Aminogeldanamycin selectively diminishes IRE1?-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
Melanoma
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
Melanoma
Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1.
Melanoma
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Melanoma
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Melanoma
Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of ?-lapachone in melanoma cell lines.
Melanoma
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Melanoma
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Melanoma
NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.
Melanoma
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
Melanoma
The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
Melanoma
The expression of NAD(P)H:quinone oxidoreductase 1 is increased along with NF-kappaB p105/p50 in human cutaneous melanomas.
Melanoma
The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells.
Melanosis
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Memory Disorders
?-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.
Memory Disorders
Transthyretin: a key gene involved in the maintenance of memory capacities during aging.
Metabolic Diseases
Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health.
Methemoglobinemia
Biochemical and functional properties of methemoglobin diaphorase in congenital methemoglobinemia.
Methemoglobinemia
Hereditary methemoglobinemia due to diaphorase deficiency in a Finnish child.
Methemoglobinemia
HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS.
Methemoglobinemia
Hereditary methemoglobinemia due to diaphorase deficiency. Report of a case of heterozygote presenting with cyanosis after birth.
Methemoglobinemia
Leukocyte diaphorase deficiency in congenital methemoglobinemia: a valuable prognostic indicator.
Methemoglobinemia
Studies on the congenital methemoglobinemia in Okinawa Island. II. Diaphorase activity.
Methemoglobinemia
The relation of diaphorase of human erythrocytes to inheritance of methemoglobinemia.
Methemoglobinemia
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
Methemoglobinemia
[Congenital methemoglobinemia caused by diaphorase deficency. (Study of 3 members of one family)]
Methemoglobinemia
[CONGENITAL METHEMOGLOBINEMIA OF THE RECESSIVE TYPE DUE TO DIAPHORASE DEFICIT WITH OLIGOPHRENIA.]
Methemoglobinemia
[Familial methemoglobinemia due to diaphorase deficiency: a 3d Swiss line]
Mitochondrial Myopathies
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
Multiple Myeloma
Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.
Multiple Sclerosis
NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions.
Multiple Sclerosis
The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease.
Multiple System Atrophy
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Muscular Diseases
Absence of nitric oxide synthase I despite the presence of the dystrophin complex in human striated muscle.
Myelodysplastic Syndromes
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
Myopathy, Central Core
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
nad(p)h dehydrogenase (quinone) deficiency
Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.
nad(p)h dehydrogenase (quinone) deficiency
Congenital methemoglobinemia due to diaphorase deficiency.
nad(p)h dehydrogenase (quinone) deficiency
Diaphorase deficiency methaemoglobinaemia mimicking cardiac disease in pregnancy.
nad(p)h dehydrogenase (quinone) deficiency
HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA.
nad(p)h dehydrogenase (quinone) deficiency
Hereditary methemoglobinemia due to diaphorase deficiency in a Finnish child.
nad(p)h dehydrogenase (quinone) deficiency
HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS.
nad(p)h dehydrogenase (quinone) deficiency
Hereditary methemoglobinemia due to diaphorase deficiency. Report of a case of heterozygote presenting with cyanosis after birth.
nad(p)h dehydrogenase (quinone) deficiency
Hereditary methemoglobinemic cyanosis due to diaphorase deficiency in three successive generations.
nad(p)h dehydrogenase (quinone) deficiency
Leukocyte diaphorase deficiency in congenital methemoglobinemia: a valuable prognostic indicator.
nad(p)h dehydrogenase (quinone) deficiency
Mental retardation in methemoglobinemia due to diaphorase deficiency.
nad(p)h dehydrogenase (quinone) deficiency
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
nad(p)h dehydrogenase (quinone) deficiency
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
nad(p)h dehydrogenase (quinone) deficiency
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
nad(p)h dehydrogenase (quinone) deficiency
[A family with congenital methemoglobinemia due to diaphorase deficiency]
nad(p)h dehydrogenase (quinone) deficiency
[Familial methemoglobinemia due to diaphorase deficiency: a 3d Swiss line]
nadh:ubiquinone reductase (h+-translocating) deficiency
The effects of idebenone on mitochondrial bioenergetics.
Neoplasm Metastasis
NQO1 as a Marker of Chemosensitivity and Prognosis for Colorectal Liver Metastasis.
Neoplasms
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
Neoplasms
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
Neoplasms
A comprehensive study of the active site residues of DT-diaphorase: rational design of benzimidazolediones as DT-diaphorase substrates.
Neoplasms
A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy.
Neoplasms
A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer.
Neoplasms
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
Neoplasms
A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy.
Neoplasms
A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells.
Neoplasms
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Neoplasms
A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation.
Neoplasms
A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy.
Neoplasms
A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells.
Neoplasms
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
Neoplasms
A self-immolative and DT-diaphorase-activatable prodrug for drug-release tracking and therapy.
Neoplasms
A sequential enzyme-activated and light-triggered pro-prodrug nanosystem for cancer detection and therapy.
Neoplasms
A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers.
Neoplasms
Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards.
Neoplasms
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Neoplasms
Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury.
Neoplasms
Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.
Neoplasms
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
Neoplasms
Administration of the optimized ?-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model.
Neoplasms
Alternative splicing and differential expression of DT-diaphorase transcripts in human colon tumors and in peripheral mononuclear cells in response to mitomycin C treatment.
Neoplasms
An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells.
Neoplasms
An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells.
Neoplasms
An NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo.
Neoplasms
An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5-Fluorouracil for Safe and Effective Cancer Therapy.
Neoplasms
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
Neoplasms
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
Neoplasms
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
Neoplasms
Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii.
Neoplasms
Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.
Neoplasms
Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression.
Neoplasms
Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications.
Neoplasms
Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression.
Neoplasms
Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy.
Neoplasms
Association Between Polymorphisms in the Genes for Tumor Suppressor Protein p53 and its Regulator NAD(P)H: Quinone Oxidoreductase 1 (NQO1) and Schizophrenia in a Syrian Study Cohort.
Neoplasms
Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Neoplasms
Associations between disease risk and eight polymorphisms adopted for genotype announcements at Nagoya University Hospital.
Neoplasms
Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity.
Neoplasms
Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana.
Neoplasms
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Neoplasms
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Neoplasms
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Neoplasms
Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum.
Neoplasms
Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
Neoplasms
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Neoplasms
Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model.
Neoplasms
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
Neoplasms
Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism.
Neoplasms
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.
Neoplasms
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Neoplasms
Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity.
Neoplasms
Carbazole-, Aspidofractinine-, and Aspidocarpamine-Type Alkaloids from Pleiocarpa pycnantha.
Neoplasms
Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of ?-lapachone in melanoma cell lines.
Neoplasms
Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
Neoplasms
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Neoplasms
Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies.
Neoplasms
Chemical profile of mango (Mangifera indica L.) using electrospray ionisation mass spectrometry (ESI-MS).
Neoplasms
Chemiluminescent Probe for the In?Vitro and In?Vivo Imaging of Cancers Over-Expressing NQO1.
Neoplasms
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE).
Neoplasms
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Neoplasms
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.
Neoplasms
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Neoplasms
Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C.
Neoplasms
Combination of Double-Mediator System with Large-Scale Integration-Based Amperometric Devices for Detecting NAD(P)H:quinone Oxidoreductase 1 Activity of Cancer Cell Aggregates.
Neoplasms
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.
Neoplasms
Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.
Neoplasms
Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risks of Colorectal Adenoma and Cancer for Caucasians: A Meta-analysis.
Neoplasms
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
Neoplasms
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Neoplasms
Covalent-Assembly Based Fluorescent Probes for Detection of hNQO1 and Imaging in Living Cells.
Neoplasms
Cutaneous NAD(P)H: quinone reductase: a xenobiotica-metabolizing enzyme with potential cancer and oxidation stress-protecting properties.
Neoplasms
Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities.
Neoplasms
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Neoplasms
Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles.
Neoplasms
Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Neoplasms
Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation.
Neoplasms
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Neoplasms
Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis.
Neoplasms
Design and synthesis of NQO1 responsive fluorescence probe and its application in bio-imaging for cancer diagnosis.
Neoplasms
Design of cancer-specific antitumor agents based on aziridinylcyclopent[b]indoloquinones.
Neoplasms
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Neoplasms
Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.
Neoplasms
Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices.
Neoplasms
Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.
Neoplasms
Detoxifying enzymes in human ovarian tissues: comparison of normal and tumor tissues and effects of chemotherapy.
Neoplasms
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.
Neoplasms
Development of a lyophilised RH1 formulation: a novel DT diaphorase activated alkylating agent.
Neoplasms
Development of a second-generation radiofrequency ablation using sintered MgFe(2)O(4) needles and alternating magnetic field for human cancer therapy.
Neoplasms
Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
Neoplasms
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Neoplasms
Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells.
Neoplasms
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Neoplasms
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
Neoplasms
Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures.
Neoplasms
Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.
Neoplasms
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
Neoplasms
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Neoplasms
DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation.
Neoplasms
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Neoplasms
DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.
Neoplasms
DT-diaphorase triggered theranostic nanoparticles induce the self-burst of reactive oxygen species for tumor diagnosis and treatment.
Neoplasms
Effect of ?-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents.
Neoplasms
Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes.
Neoplasms
Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Neoplasms
Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats.
Neoplasms
Effects of psoralen from Psoralea corylifolia on quinone reductase, ornithine decarboxylase, and JB6 cells transformation promotion.
Neoplasms
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin CÅ.
Neoplasms
Endophytic fungi associated with Taxus fuana (West Himalayan Yew) of Pakistan: potential bio-resources for cancer chemopreventive agents.
Neoplasms
Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging.
Neoplasms
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Neoplasms
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Neoplasms
Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.
Neoplasms
Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.
Neoplasms
Enzyme-Triggered Disassembly of Polymeric Micelles by Controlled Depolymerization via Cascade Cyclization for Anticancer Drug Delivery.
Neoplasms
Enzymology of mitomycin C metabolic activation in tumour tissue. Characterization of a novel mitochondrial reductase.
Neoplasms
Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development.
Neoplasms
Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Neoplasms
Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
Neoplasms
Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
Neoplasms
Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity.
Neoplasms
Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts.
Neoplasms
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Neoplasms
Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia.
Neoplasms
Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines.
Neoplasms
FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.
Neoplasms
Gamma-tocopherol supplementation ameliorated hyper-inflammatory response during the early cutaneous wound healing in alloxan-induced diabetic mice.
Neoplasms
Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance.
Neoplasms
Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice.
Neoplasms
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Neoplasms
Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.
Neoplasms
Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).
Neoplasms
Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.
Neoplasms
Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds.
Neoplasms
High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin.
Neoplasms
Histochemistry of therapeutically relevant enzymes in human tumours transplanted into severe combined immunodeficient (SCID) mice: nitric oxide synthase-associated diaphorase, beta-D-glucuronidase and non-specific alkaline phosphatase.
Neoplasms
Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue.
Neoplasms
Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan.
Neoplasms
Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups.
Neoplasms
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Neoplasms
Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
Neoplasms
Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex.
Neoplasms
Identification of novel NAD(P)H dehydrogenase [quinone] 1 antagonist using computational approaches.
Neoplasms
Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.
Neoplasms
Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors.
Neoplasms
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Neoplasms
Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes.
Neoplasms
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Neoplasms
Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone.
Neoplasms
In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens.
Neoplasms
In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro.
Neoplasms
Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies.
Neoplasms
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A Potential biomarker of early damage in the pancreas.
Neoplasms
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas.
Neoplasms
Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD(P)H:quinone reductase.
Neoplasms
Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.
Neoplasms
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Neoplasms
Induction of DT-diaphorase by doxorubicin and combination therapy with mitomycin C in vitro.
Neoplasms
Induction of NAD (P)H: Quinone reductase 1 (QR1) and antioxidant activities in vitro of 'Toranja Burarama' (Citrus maxima [Burm.] Merr.).
Neoplasms
Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.
Neoplasms
Induction of quinone reductase activity by stilbene analogs in mouse Hepa 1c1c7 cells.
Neoplasms
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Neoplasms
Induction of quinone reductase by withanolides isolated from Physalis philadelphica (tomatillos).
Neoplasms
Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts.
Neoplasms
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: A mechanism of cancer chemoprotection.
Neoplasms
Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.
Neoplasms
Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism.
Neoplasms
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.
Neoplasms
Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2.
Neoplasms
Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release.
Neoplasms
Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.
Neoplasms
Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia.
Neoplasms
Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species.
Neoplasms
Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.).
Neoplasms
Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa).
Neoplasms
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells.
Neoplasms
Lack of NQO1 induction in human tumor cells is not due to changes in the promoter region of the gene.
Neoplasms
Light-Enhanced Hypoxia-Response of Conjugated Polymer Nanocarrier for Successive Synergistic Photodynamic and Chemo-Therapy.
Neoplasms
Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen.
Neoplasms
Lupeol, a triterpene, prevents free radical mediated macromolecular damage and alleviates benzoyl peroxide induced biochemical alterations in murine skin.
Neoplasms
Mechanism of inhibition of estrogen-induced renal carcinogenesis in male Syrian hamsters by vitamin C.
Neoplasms
Mesoporous nanocarriers with a stimulus-responsive cyclodextrin gatekeeper for targeting tumor hypoxia.
Neoplasms
Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.
Neoplasms
miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.
Neoplasms
Mitochondria-targeted aggregation induced emission theranostics: crucial importance of in situ activation.
Neoplasms
Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor)oxidoreductase.
Neoplasms
Modulation of Nad(P)H:quinone oxidoreductase (NQO1) activity mediated by 5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential.
Neoplasms
Modulation of xenobiotic-metabolizing enzymes by ethanolic neem leaf extract during hamster buccal pouch carcinogenesis.
Neoplasms
Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.
Neoplasms
Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.
Neoplasms
Multifunctional Programmable DNA Nanotrain for Activatable Hypoxia Imaging and Mitochondrion-Targeted Enhanced Photodynamic Therapy.
Neoplasms
NAD(P)H quinone oxidoreductase 1 (NQO1) genetic C609T polymorphism is associated with the risk of digestive tract cancer: a meta-analysis based on 21 case-control studies.
Neoplasms
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
Neoplasms
NAD(P)H Quinone Oxidoreductase-1 in Organ and Tumor Tissues: Distinct Activity Levels Observed with a Benzo-rosol-Based Dual-Excitation and Dual-Emission Probe.
Neoplasms
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis.
Neoplasms
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Neoplasms
NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype.
Neoplasms
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer.
Neoplasms
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Neoplasms
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
Neoplasms
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by ?-lapachone.
Neoplasms
Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.
Neoplasms
Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Neoplasms
Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents.
Neoplasms
New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Neoplasms
Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells.
Neoplasms
No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancers.
Neoplasms
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Neoplasms
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Neoplasms
Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC).
Neoplasms
Novel tumor-ablation device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Neoplasms
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance.
Neoplasms
NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis.
Neoplasms
NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.
Neoplasms
Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes.
Neoplasms
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC ?/?II by Gymnasterkoreayne B.
Neoplasms
Over-expression of DT-diaphorase in transfected NIH 3T3 cells does not lead to increased anticancer quinone drug sensitivity: a questionable role for the enzyme as a target for bioreductively activated anticancer drugs.
Neoplasms
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Neoplasms
Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1? Pathway.
Neoplasms
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.
Neoplasms
Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
Neoplasms
Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.
Neoplasms
Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: structure/activity relationships and functional activity in tumour cells.
Neoplasms
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
Neoplasms
Phase 1 study of ARQ 761, a ?-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis.
Neoplasms
Phase I study of napabucasin in combination with FOLFIRI?+?bevacizumab in Japanese patients with metastatic colorectal cancer.
Neoplasms
Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.
Neoplasms
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Neoplasms
Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity.
Neoplasms
Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
Neoplasms
Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development.
Neoplasms
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Neoplasms
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.
Neoplasms
Quinone reductase activity in the first trimester placenta: effect of cigarette smoking and polycyclic aromatic hydrocarbons.
Neoplasms
Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography.
Neoplasms
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
Neoplasms
Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
Neoplasms
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Neoplasms
Relationship between the antioxidant enzyme DT-diaphorase and tumor response to mitomycin C treatment.
Neoplasms
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
Neoplasms
Relevance of DT-diaphorase activity to mitomycin C (MMC) efficacy on human cancer cells: differences in in vitro and in vivo systems.
Neoplasms
Retraction: NRH:Quinone Oxidoreductase 2 and NAD(P)H:Quinone Oxidoreductase 1 Protect Tumor Suppressor p53 against 20S Proteasomal Degradation Leading to Stabilization and Activation of p53.
Neoplasms
Role of NAD(P)H:quinone oxidoreductase 1 on tumor necrosis factor-alpha-induced migration of human vascular smooth muscle cells.
Neoplasms
Role of NAD(P)H:quinone oxidoreductase polymorphism at codon 187 in susceptibility to lung, laryngeal and oral/pharyngeal cancers.
Neoplasms
Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs.
Neoplasms
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
Neoplasms
Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.
Neoplasms
Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review.
Neoplasms
Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Neoplasms
Structure-activity study with bioreductive benzoquinone alkylating agents: effects on DT-diaphorase-mediated DNA crosslink and strand break formation in relation to mechanisms of cytotoxicity.
Neoplasms
Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells.
Neoplasms
Sulindac compounds facilitate the cytotoxicity of ?-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.
Neoplasms
Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents.
Neoplasms
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
Neoplasms
Systemic delivery and preclinical evaluation of Au nanoparticle containing beta-lapachone for radiosensitization.
Neoplasms
Tailoring targeted therapy to individual patients: lessons to be learnt from the development of mitomycin C.
Neoplasms
Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.
Neoplasms
Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin.
Neoplasms
The Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) is required for tumor initiation by benzo(a)pyrene.
Neoplasms
The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
Neoplasms
The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.
Neoplasms
The Inhibition Kinetics and Potential Anti-Migration Activity of NQO1 Inhibitory Coumarins on Cholangiocarcinoma Cells.
Neoplasms
The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
Neoplasms
The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.
Neoplasms
The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).
Neoplasms
The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
Neoplasms
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Neoplasms
The role of rhynchophylline in alleviating early brain injury following subarachnoid hemorrhage in rats.
Neoplasms
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.
Neoplasms
Transcription Factor Nrf2 Plays a Pivotal Role in Protection Against Traumatic Brain Injury-Induced Acute Intestinal Mucosal Injury in Mice.
Neoplasms
Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Neoplasms
Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers.
Neoplasms
Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy.
Neoplasms
Ultrasound-guided laser-induced thermal therapy for small palpable invasive breast carcinomas: a feasibility study.
Neoplasms
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
Neoplasms
Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.
Neoplasms
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Neoplasms
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Neoplasms
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Neoplasms
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Neoplasms
[Acquisition of resistance associated with impairment of metabolic activation of anticancer drugs]
Neoplasms
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)]
Neoplasms
[Mitomycin C and its bioreduction: relevance of NAD(P)H: quinone oxidoreductase activity to mitomycin C-induced DNA damage and cytotoxicity]
Neuralgia
Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation.
Neuralgia
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
Neuralgia
Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain.
Neuralgia
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.
Neuroblastoma
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1.
Neuroblastoma
Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide.
Neuroblastoma
Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity.
Neuroblastoma
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.
Neuroblastoma
Sulforaphane as an Inducer of Glutathione Prevents Oxidative Stress-induced Cell Death in a Dopaminergic-like Neuroblastoma Cell Line.
Neuroblastoma
The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
Neuroblastoma
The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I.
Neurodegenerative Diseases
Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures.
Neurodegenerative Diseases
Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress.
Neuroectodermal Tumors
[Histochemistry of the oxidation-reduction enzymes in the cells of neuroectodermal tumors]
Neuroinflammatory Diseases
?-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.
Neutropenia
ABCB1 polymorphism as a predictive biomarker for amrubicin-induced neutropenia.
Nijmegen Breakage Syndrome
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Obesity
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.
Obesity
NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.
Odontogenic Cysts
Enzyme histochemical studies on the formation of hyalin bodies in the epithelium of odontogenic cysts.
Osteoarthritis
The Inhibitory Effects of Slow-Releasing Hydrogen Sulfide Donors in the Mechanical Allodynia, Grip Strength Deficits, and Depressive-Like Behaviors Associated with Chronic Osteoarthritis Pain.
Ovarian Neoplasms
Characteristics of ovarian cancer detection by a near-infrared fluorescent probe activated by human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1).
Ovarian Neoplasms
Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines.
Ovarian Neoplasms
NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism.
Pancreatic Diseases
Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.
Pancreatic Neoplasms
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
Pancreatic Neoplasms
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Pancreatic Neoplasms
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Pancreatic Neoplasms
DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition.
Pancreatic Neoplasms
Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.
Pancreatic Neoplasms
Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of ?-lapachone for pancreatic cancer therapy.
Pancreatic Neoplasms
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Pancreatic Neoplasms
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
Pancreatic Neoplasms
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Pancreatitis
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.
Parathyroid Neoplasms
Nitric Oxide Synthase in Human Parathyroid Glands and Parathyroid Adenomas.
Parkinson Disease
Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats.
Parkinson Disease
On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.
Parkinson Disease
Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death.
Parkinson Disease
Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.
Parkinson Disease
[A study on the relationship between polymorphism of human NAD(P)H: quinone oxidoreductase and Parkinson's disease in Chinese]
Parkinson Disease
[Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease]
Pouchitis
Azoreductase and nitroreductase activity of bacteria in feces from patients with an ileal reservoir.
Pre-Eclampsia
L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased Risk for Acute Lymphoblastic Leukemia in Children with Cytochrome P(450) A(1)(CYP1A1)- and NAD(P)H:Quinone Oxidoreductase 1 (NQO1)-Inherited Gene Variants.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Molecular biomarkers for the study of childhood leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
Prostatic Hyperplasia
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
Prostatic Hyperplasia
NAD(P)H-quinone oxidoreductase 1 silencing aggravates hormone-induced prostatic hyperplasia in mice.
Prostatic Neoplasms
?-Lapachone Induces NQO1- and Oxidative Stress-Dependent Hsp90 Cleavage and Inhibits Tumor Growth and Angiogenesis.
Prostatic Neoplasms
beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.
Prostatic Neoplasms
Identification of potential prostate cancer preventive agents through induction of quinone reductase in vitro.
Prostatic Neoplasms
Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.
Prostatic Neoplasms
Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer.
Prostatic Neoplasms
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) P187S Polymorphism and Prostate Cancer Risk in Caucasians.
Prostatic Neoplasms
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Pulmonary Disease, Chronic Obstructive
Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients.
Pyloric Stenosis, Hypertrophic
Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis.
Sarcoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Sarcoma, Synovial
NAD(P)H Quinone Oxidoreductase 1 (NQO1)-Bioactivated Pronqodine A Regulates Prostaglandin Release from Human Synovial Sarcoma Cells.
Skin Neoplasms
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer.
Skin Neoplasms
Stress-induced NQO1 controls stability of C/EBP? against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.
Small Cell Lung Carcinoma
NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.
Small Cell Lung Carcinoma
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Spinal Cord Injuries
Histochemical evidence of the increased expression of nicotinamide adenine dinucleotide phosphate-dependent diaphorase in neurons of the myenteric plexus after acute spinal cord injury in adult rats.
Squamous Cell Carcinoma of Head and Neck
Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy.
Starvation
Characterization and analysis of an NAD(P)H dehydrogenase transcriptional regulator critical for the survival of cyanobacteria facing inorganic carbon starvation and osmotic stress.
Stomach Neoplasms
A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.
Stomach Neoplasms
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Stomach Neoplasms
Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians.
Stomach Neoplasms
Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation.
Stomach Neoplasms
[Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer.]
Tardive Dyskinesia
No association between a functional NAD(P)H: quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia.
Thyroid Nodule
[Cyto-inactivation instantly induced by microwave ablation on thyroid nodules].
Triple Negative Breast Neoplasms
Following anticancer drug activity in cell lysates with DNA devices.
Triple Negative Breast Neoplasms
NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
Tuberculosis
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.
Tuberculosis
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.
Tuberculosis
Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice.
Tuberculosis
Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria.
Urinary Bladder Diseases
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
Urinary Bladder Neoplasms
A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9.
Urinary Bladder Neoplasms
Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer.
Urinary Bladder Neoplasms
Association of Bladder Cancer Risk with an NAD(P)H:Quinone Oxidoreductase Polymorphism in an Ethnic Kashmiri Population.
Urinary Bladder Neoplasms
CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population.
Urinary Bladder Neoplasms
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
Urinary Bladder Neoplasms
Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay.
Urinary Bladder Neoplasms
Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors.
Urinary Bladder Neoplasms
Genetic polymorphisms in NQO1 and SOD2: Interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.
Urinary Bladder Neoplasms
Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.
Urinary Bladder Neoplasms
Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.
Urinary Bladder Neoplasms
Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus fries and polyporus polysaccharide.
Urinary Bladder Neoplasms
Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina.
Urinary Bladder Neoplasms
NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.
Urinary Bladder Neoplasms
No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancers.
Urinary Bladder Neoplasms
Pesticide, Gene Polymorphisms and Bladder Cancer among Egyptian Agricultural Workers.
Urinary Bladder Neoplasms
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Urinary Bladder Neoplasms
The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects.
Uterine Cervical Neoplasms
Association of the NAD(P)H: quinone oxidoreductase C609T polymorphism and the risk of cervical cancer in Japanese subjects.
Uterine Cervical Neoplasms
NAD(P)H: quinone oxidoreductase 1 gene rs1800566 polymorphism increases the risk of cervical cancer in a Chinese Han sample: A STROBE-complaint case-control study.
Vascular System Injuries
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Vascular System Injuries
The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction.
Virus Diseases
[Diaphorase activity at the conjunctival level in an experimentally produced viral infection]
Vitamin A Deficiency
Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver.
Xeroderma Pigmentosum
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
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