Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DL-delta-hydroxylysine + 2-oxoglutarate + NADPH
?
-
18% of velocity with equimolar concentration of L-lysine
-
-
?
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADH + H+
-
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
additional information
?
-
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
unidirectional lysine catabolic activity
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
uni-directional activity plays an important role in regulating the catabolic function of alpha-aminoadipidic acid pathway in plants and stems from structure rather than its linkage to saccharopine dehydrogenase EC 1.5.1.9
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first enzyme in lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
major catabolic pathway of lysine in mammalian livers
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
L-lysine catabolism is reversibly osmo-regulated at the level of LKR/SDH bifunctional enzyme
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and possibly a rate-limiting step in lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and major regulatory step in lysine catabolism, lysine may auto-regulate its own catabolism in vivo, plant seeds: active enzyme is a phosphoprotein, its activity is modulated by opposing actions of protein kinases and phosphatases
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
reverse reaction not detected
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?, ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
reverse reaction not detected
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
important role in the degradation of lysine
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is stimulated in vivo upon treatment with protein phosphatase inhibitor
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
equilibrium favors sacharopine formation, lysine formation is only 3-5% of the saccharopine formation
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
lysine formation is only 3-5% of the saccharopine formation
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
NAD+ as electron acceptor for L-lysine formation
?, r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?, r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
increase in free lysine concentration in cells decrease enzyme activity through repression of lys1 gene, precursor alpha-aminoadipic-delta-semialdehyde modulates a transcriptional factor that controls transcription of lys1 gene
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
plays essential role in lysine biosynthesis, LKR and SDH are separate polypeptides
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine anabolic function is regulated by complex transcriptional and post-transcriptional controls
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
specific for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
specific for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
activity of native enzyme is inhibited after modulation, enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding, Ca2+ may be the most important physiological modulator of enzyme activity, it possibly activates through the derepression of an inhibitory domain in vivo
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first step in lysine breakdown in the endosperm during seed development
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the enzyme is involved in lysine degradation
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
A0A3L6FCN0
reaction of the LKR domain
-
-
r
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
47% of velocity with equimolar concentration of L-lysine
-
-
?
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
52% of activity with equimolar concentration of L-lysine, same Vmax, but higher Km-value than for L-lysine
-
-
?
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
52% of activity with equimolar concentration of L-lysine, same Vmax, but higher Km-value than for L-lysine
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
less than 2% of the rate of L-lysine: D-lysine, cadaverine, delta-aminovaleric acid, alpha-acetyl-L-lysine, alpha-amino-epsilon-hydroxycaproic acid, L-lysylglycine, L-2,4-diaminobutyric acid, DL-pipecolic acid, L-ornithine, epsilon-aminocaproic acid, 4% of the rate of L-lysine: DL-alpha,epsilon-diaminopimelic acid, 7% of the rate of 2-oxoglutarate: oxaloacetic acid, less than 2% of the rate of 2-oxoglutarate: 2-oxoadipate, pyruvate, 2-oxoisocaproate, 2-oxoisovalerate, levulinate, 2-hydroxyglutarate
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming)
-
-
?
additional information
?
-
-
the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming)
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
not as electron acceptor: NADH
-
-
?
additional information
?
-
-
lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 are separate enzymes
-
-
?
additional information
?
-
-
not as substrates: ornithine, glutamine, oxaloacetate, pyruvate
-
-
?
additional information
?
-
-
not as electron acceptor: NADH
-
-
?
additional information
?
-
-
lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 are separate enzymes
-
-
?
additional information
?
-
-
not as substrates: ornithine, glutamine, oxaloacetate, pyruvate
-
-
?
additional information
?
-
-
not as electron acceptor: NADH
-
-
?
additional information
?
-
-
not as substrates: L-ornithine, D-lysine, oxaloacetate, pyruvate
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
A0A3L6FCN0
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADH + H+
-
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
uni-directional activity plays an important role in regulating the catabolic function of alpha-aminoadipidic acid pathway in plants and stems from structure rather than its linkage to saccharopine dehydrogenase EC 1.5.1.9
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first enzyme in lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
major catabolic pathway of lysine in mammalian livers
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
L-lysine catabolism is reversibly osmo-regulated at the level of LKR/SDH bifunctional enzyme
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and possibly a rate-limiting step in lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and major regulatory step in lysine catabolism, lysine may auto-regulate its own catabolism in vivo, plant seeds: active enzyme is a phosphoprotein, its activity is modulated by opposing actions of protein kinases and phosphatases
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
important role in the degradation of lysine
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is stimulated in vivo upon treatment with protein phosphatase inhibitor
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
increase in free lysine concentration in cells decrease enzyme activity through repression of lys1 gene, precursor alpha-aminoadipic-delta-semialdehyde modulates a transcriptional factor that controls transcription of lys1 gene
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
plays essential role in lysine biosynthesis, LKR and SDH are separate polypeptides
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine anabolic function is regulated by complex transcriptional and post-transcriptional controls
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
activity of native enzyme is inhibited after modulation, enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding, Ca2+ may be the most important physiological modulator of enzyme activity, it possibly activates through the derepression of an inhibitory domain in vivo
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first step in lysine breakdown in the endosperm during seed development
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the enzyme is involved in lysine degradation
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
A0A3L6FCN0
reaction of the LKR domain
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Davis, A.T.
Assay for lysine-ketoglutarate reductase by reversed-phase high-performance liquid chromatography
J. Chromatogr.
497
263-267
1989
Rattus norvegicus
brenda
Arruda, P.; Sodek, L.; Da Silva, W.J.
Lysine-ketoglutarate reductase activity in developing maize endosperm
Plant Physiol.
69
988-989
1982
Zea mays
brenda
Arruda, P.; Da Silva, W.J.
Lysine-ketoglutarate reductase activity in maize: Its possible role in lysine metabolism of developing endosperm
Phytochemistry
22
2687-2689
1983
Zea mays
-
brenda
Noda, C.; Ichihara, A.
Purification and properties of L-lysine-alpha-ketoglutarate reductase from rat liver mitochondria
Biochim. Biophys. Acta
525
307-313
1978
Rattus norvegicus, Rattus norvegicus male Wistar
brenda
Fjellstedt, T.A.; Robinson, J.C.
Purification and properties of L-lysine-alpha-ketoglutarate reductase from human placenta
Arch. Biochem. Biophys.
168
536-548
1975
Homo sapiens
brenda
Hutzler, J.; Dancis, J.
Lysine-ketoglutarate reductase in human tissues
Biochim. Biophys. Acta
377
42-51
1975
Homo sapiens
brenda
Hutzler, J.; Dancis, J.
Conversion of lysine to saccharopine by human tissues
Biochim. Biophys. Acta
158
62-69
1968
Homo sapiens
brenda
Fellows, F.C.I.; Lewis, M.H.R.
Lysine metabolism in mammals
Biochem. J.
136
329-334
1973
Bos taurus, Canis lupus familiaris, Felis catus, Homo sapiens, Ovis aries, Rattus norvegicus, Rattus norvegicus Wistar, Sus scrofa
brenda
Markovitz, P.J.; Chuang, D.T.; Cox, R.P.
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
J. Biol. Chem.
259
11643-11646
1984
Bos taurus, Homo sapiens, Papio sp.
brenda
Markovitz, P.J.; Chuang, D.T.
The bifunctional aminoadipic semialdehyde synthase in lysine degradation. Separation of reductase and dehydrogenase domains by limited proteolysis and column chromatography
J. Biol. Chem.
262
9353-9358
1987
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Neurospora sp.
brenda
Blemings, K.P.; Crenshaw, T.D.; Swick, R.W.; Benevenga, N.J.
Lysine-alpha-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver
J. Nutr.
124
1215-1221
1994
Rattus norvegicus
brenda
Gaziola, S.A.; Sodek, L.; Arruda, P.; Lea, P.J.; Azevedo, R.A.
Degradation of lysine in rice seeds: Effect of calcium, ionic strength, S-adenosylmethionine and S-2-aminoethyl-L-cysteine on the lysine 2-oxoglutarate reductase-saccharopine dehydrogenase bifunctional enzyme
Physiol. Plant.
110
164-171
2000
Arabidopsis thaliana, Oryza sativa, Zea mays, Oryza sativa IAC 165
-
brenda
Zhu, X.; Tang, G.; Galili, G.
The catabolic function of the alpha-aminoadipic acid pathway in plants is associated with unidirectional activity of lysine-oxoglutarate reductase, but not saccharopine dehydrogenase
Biochem. J.
351
215-220
2000
Arabidopsis thaliana, Saccharomyces cerevisiae
brenda
Kemper, E.L.; Cord-Neto, G.; Capella, A.N.; Goncalves-Butruile, M.; Azevedo, R.; Arruda, P.
Structure and regulation of the bifunctional enzyme lysine-oxoglutarate reductase-saccharopine dehydrogenase in maize
Eur. J. Biochem.
253
720-729
1998
Saccharomyces cerevisiae, Nicotiana tabacum, Zea mays
brenda
Gaziola, S.A.; Teixeira, C.M.; Lugli, J.; Sodek, L.; Azevedo, R.A.
The enzymology of lysine catabolism in rice seeds. Isolation, characterization, and regulatory properties of a lysine 2-oxoglutarate reductase/saccharopine dehydrogenase bifunctional polypeptide
Eur. J. Biochem.
247
364-371
1997
Oryza sativa, Oryza sativa IAC 165
brenda
Miron, D.; Ben-Yaacov, S.; Karchi, H.; Galili, G.
In vitro dephosphorylation inhibits the activity of soybean lysine-ketoglutarate reductase in a lysine-regulated manner
Plant J.
12
1453-1458
1997
Glycine max, Nicotiana tabacum
-
brenda
Epelbaum, S.; McDevitt, R.; Falco, S.C.
Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana: Nucleotide sequence and characterization
Plant Mol. Biol.
35
735-748
1997
Arabidopsis thaliana, Nicotiana tabacum
brenda
Moulin, M.; Deleu, C.; Larher, F.
L-Lysine catabolism is osmo-regulated at the level of lysine-ketoglutarate reductase and saccharopine dehydrogenase in rapeseed leaf discs
Plant Physiol. Biochem.
38
577-585
2000
Brassica napus
-
brenda
Miron, D.; Ben-Yaacov, S.; Reches, D.; Schupper, A.; Galili, G.
Purification and characterization of bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase from developing soybean seeds
Plant Physiol.
123
655-663
2000
Glycine max, Oryza sativa, Zea mays
brenda
Tang, G.; Miron, D.; Zhu-Shimoni, J.X.; Galili, G.
Regulation of lysine catabolism through lysine-ketoglutarate reductase and saccharopine dehydrogenase in Arabidopsis
Plant Cell
9
1305-1316
1997
Arabidopsis thaliana, Saccharomyces cerevisiae
brenda
Cunha Lima, S.T.; Azevedo, R.A.; Santoro, L.G.; Gaziola, S.A.; Lea, P.J.
Isolation of the bifunctional enzyme lysine 2-oxoglutarate reductase-saccharopine dehydrogenase from Phaseolus vulgaris
Amino Acids
24
179-186
2003
Phaseolus vulgaris
brenda
Azevedo, R.A.; Damerval, C.; Landry, J.; Lea, P.J.; Bellato, C.M.; Meinhardt, L.W.; Le Guilloux, M.; Delhaye, S.; Toro, A.A.; Gaziola, S.A.; Berdejo, B.D.A.
Regulation of maize lysine metabolism and endosperm protein synthesis by opaque and floury mutations
Eur. J. Biochem.
270
4898-4908
2003
Zea mays
brenda
Fornazier, R.F.; Gaziola, S.A.; Helm, C.V.; Lea, P.J.; Azevedo, R.A.
Isolation and characterization of enzymes involved in lysine catabolism from sorghum seeds
J. Agric. Food Chem.
53
1791-1798
2005
Sorghum bicolor, Sorghum bicolor Moench
brenda
Manangi, M.K.; Hoewing, S.F.A.; Engels, J.G.; Higgins, A.D.; Killefer, J.; Wilson, M.E.; Blemings, K.P.
Lysine aLPHA-ketoglutarate reductase and lysine oxidation are distributed in the extrahepatic tissues of chickens
J. Nutr.
135
81-85
2005
Gallus gallus
brenda
Stepansky, A.; Galili, G.
Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals
Plant Physiol.
133
1407-1415
2003
Arabidopsis sp.
brenda
Battur, B.; Boldbaatar, D.; Umemiya-Shirafuji, R.; Liao, M.; Battsetseg, B.; Taylor, D.; Baymbaa, B.; Fujisaki, K.
LKR/SDH plays important roles throughout the tick life cycle including a long starvation period
PLoS ONE
4
e7136
2009
Haemaphysalis longicornis
brenda
Umair, S.; Bland, R.J.; Simpson, H.V.
Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta
Exp. Parasitol.
131
101-106
2012
Haemonchus contortus, Teladorsagia circumcincta
brenda
Schmidt, D.; Rizzi, V.; Gaziola, S.A.; Medici, L.O.; Vincze, E.; Kozak, M.; Lea, P.J.; Azevedo, R.A.
Lysine metabolism in antisense C-hordein barley grains
Plant Physiol. Biochem.
87
73-83
2015
Hordeum vulgare
brenda
Wan, P.; Yuan, S.; Tang, Y.; Li, K.; Yang, L.; Fu, Q.; Li, G.
Pathways of amino acid degradation in Nilaparvata lugens (Stal) with special reference to lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH)
PLoS ONE
10
e0127789
2015
Nilaparvata lugens (A0A089MUZ6), Nilaparvata lugens
brenda
Arruda, P.; Barreto, P.
Lysine catabolism through the saccharopine pathway enzymes and intermediates involved in plant responses to abiotic and biotic stress
Front. Plant Sci.
11
587
2020
Arabidopsis thaliana (Q9SMZ4), Brassica napus (Q9FVF4), Homo sapiens (Q9UDR5), Oryza sativa (A0A0K0K9B1), Zea mays (A0A3L6FCN0)
brenda