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Information on EC 1.3.1.81 - (+)-pulegone reductase

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EC Tree
     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.81 (+)-pulegone reductase
IUBMB Comments
NADH cannot replace NADPH as reductant. The Delta8,9-double bond of (+)-cis-isopulegone and the Delta1,2-double bond of (+/-)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
(+)-pulegone reductase, pulegone reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+
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(-)-menthone + NADP+ = (+)-pulegone + NADPH + H+
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