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Information on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

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IUBMB Comments
Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
vkorl1, vitamin ko reductase, vitamin k 2,3 epoxide reductase, non-vkor, vkor-like1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol
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