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1-(4-hydroxybenzyl)imidazole + ascorbate + O2
4-hydroxybenzaldehyde + dehydroascorbate + H2O + ?
-
-
-
?
1-(4-hydroxybenzyl)imidazole + ascorbate + O2
?
-
-
-
-
?
1-phenyl-1-aminomethylethene + ascorbate + O2
2,3-dihydroxy-2-phenylpropylamine + dehydroascorbate + H2O + ?
-
ascorbate and ferrocyanide can function as a electron donors
-
?
1-phenylethylamine + ascorbate + O2
?
-
-
-
-
?
2-(4-hydroxyphenyl)prop-2-enylamine + ascorbate + O2
?
-
-
-
-
?
2-aminoindane + ascorbate + O2
trans-(1S,2S)-2-amino-1-indanol + H2O
-
Stereochemistry is in contrast to the stereochemical course of pro-R hydroxylation of the DBH/phenethylamine reaction. Studies with stereospecifically deuterium labelled substrate show that the production of (1S)-aminoindanol ir the result of sterospecific pro-S hydrogen abstraction followed by the oxygen binding with overall retention of configuration
-
?
2-bromo-3-(p-hydroxyphenyl)-1-propene + ascorbate + O2
2-bromo-3-hydroxy-3-(p-hydroxyphenyl)-1-propene + H2O
-
-
-
?
2-chlorophenethylamine + ascorbate + O2
2-amino-1-chloro-1-phenylethanol + dehydroascorbate + H2O
-
-
-
?
2-hydroxyphenethylamine + ascorbate + O2
2-amino-1-phenylethane-1,1-diol + dehydroascorbate + H2O
-
-
-
?
2-phenylethylamine + ascorbate + O2
?
-
-
-
-
?
2-phenylprop-2-enylamine + ascorbate + O2
?
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
3-phenylpropylamine + ascorbate + O2
?
-
-
-
-
?
4-hydroxy-alpha-methylstyrene + ascorbate + O2
?
-
-
-
-
?
4-hydroxybenzyl cyanide + ascorbate + O2
4-hydroxymandelonitrile + dehydroascorbate + H2O
-
and benzyl cyanide analogs
-
?
4-hydroxyphenyl-2-aminoethyl sulfide + ascorbate + O2
4-hydroxyphenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
-
-
?
4-hydroxyphenyl-2-aminopropyl selenide + ascorbate + O2
4-hydroxyphenyl-2-aminopropyl selenoxide + dehydroascorbate + H2O
-
-
-
?
beta,beta-dideuterated tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
dopamine + ascorbate + O2
norepinephrine + dehydroascorbate + H2O
-
-
-
-
?
dopamine + D-araboascorbic acid + O2
?
-
-
-
-
r
dopamine + D-xyloascorbic acid + O2
?
-
-
-
-
r
dopamine + L-araboascorbic acid + O2
?
-
-
-
-
r
N-phenylethylenediamine + ascorbate + O2
?
-
-
-
-
?
octopamine + ascorbate + O2
?
-
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
phenylacetaldehyde + ascorbate + O2
?
-
-
-
-
?
phenylaminoethyl sulfide + ascorbate + O2
?
-
-
-
-
?
phenylethylamine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + ferrocyanide
octopamine + dehydroascorbate + ?
-
-
-
-
?
tyramine + ascorbate + N,N,N',N'-tetramethyl-p-phenylenediamine
octopamine + dehydroascorbate + ?
-
-
-
-
?
tyramine + ascorbate + N,N-dimethyl-p-phenylenediamine
octopamine + dehydroascorbate + ?
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
tyramine + N-(4-chlorophenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-chlorophenyl)urea + (4-chlorophenyl)cyanamide + 1-oxo-2-(4-chlorophenyl)guanidine + H2O
-
-
-
-
?
tyramine + N-(4-isopropylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-isopropylphenyl)urea + (4-isopropylphenyl)cyanamide + 1-oxo-2-(4-isopropylphenyl)guanidine + H2O
-
33% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
tyramine + N-(4-methoxyphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-methoxyphenyl)urea + (4-methoxyphenyl)cyanamide + 1-oxo-2-(4-methoxyphenyl)guanidine + H2O
-
-
-
-
?
tyramine + N-(4-methylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-methylphenyl)urea + (4-methylphenyl)cyanamide + 1-oxo-2-(4-methylphenyl)guanidine + H2O
-
116% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
tyramine + N-(4-trifluoromethylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-trifluoromethylphenyl)urea + (4-trifluoromethylphenyl)cyanamide + 1-oxo-2-(4-trifluoromethylphenyl)guanidine + H2O
-
16% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
additional information
?
-
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
N,N-dimethyl-1,4-phenylenediamine and ascorbic acid derivates are efficient reductants for the enzyme
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
ferrocyanide can function as a electron donor
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
D-xyloascorbic acid, L-araboascorbic acid or D-araboascorbic acid can replace L-xyloascorbic acid
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
3,4-dihydroxyphenethylamine is identical with 4-(2-aminoethyl)-1,2-benzendiol i.e. dopamine, ferricyanide can replace ascorbate
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
and derivates
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
r
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
additional information
?
-
-
enzyme with very broad substrate specificity
-
-
?
additional information
?
-
-
evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 positively regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, interaction between the two transcription factors GATA-3 and Sp1, overview
-
-
?
additional information
?
-
-
a significantly lower plasma DBH activity is found in combat veterans with posttraumatic stress disorder carrying the CC genotype as compared to veterans without posttraumatic stress disorder carrying the corresponding genotype, dependent on the genotype the regulation of DBH expression is different in response to trauma, overview
-
-
?
additional information
?
-
-
the plasma dopamine beta-hydroxylase activity is correlated with polymorphisms in the DBH gene in Eastern Indian population, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 positively regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
a noradrenalin-synthesizing enzyme from dopamine
-
-
?
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0.45
1-(4-chlorophenyl)-3-hydroxyguanidine
-
5 mM tyramine
1.9
1-(4-Hydroxybenzyl)imidazole
-
-
2.8 - 7.2
1-hydroxy-3-(4-methoxyphenyl)guanidine
8.3
1-Phenyl-1-aminomethylethene
-
-
1.3
2-(4-Hydroxyphenyl)prop-2-enylamine
-
-
3.8
2-aminoindane
-
37°C, 0.2 M acetate buffe, pI 6, with 30 mM NEM, 1 mM K4Fe(CN)6, 5 mM CuSO4
5.9
2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
-
5.1
2-chlorophenethylamine
-
-
24
2-hydroxyphenethylamine
-
-
6.7
2-Phenylprop-2-enylamine
-
-
1
3,4-Dihydroxyphenethylamine
-
-
12.2 - 20.4
3-Phenylpropylamine
3.7
4-Hydroxy-alpha-methylstyrene
-
-
1.6
4-Hydroxybenzyl cyanide
-
-
0.0906 - 0.341
beta,beta-dideuterated tyramine
1.4
D-araboascorbic acid
-
-
2.3
D-xyloascorbic acid
-
-
2.7
L-araboascorbic acid
-
-
1.5
L-xyloascorbic acid
-
-
9.1
N-Phenylethylenediamine
-
-
17.2 - 26.5
phenyl 2-aminoethyl sulfide
7.4 - 7.9
phenylacetaldehyde
additional information
additional information
-
2.8
1-hydroxy-3-(4-methoxyphenyl)guanidine
-
pH 6.0, 28°C, 0.4 mM tyramine
4.3
1-hydroxy-3-(4-methoxyphenyl)guanidine
-
pH 6.0, 28°C, 1.0 mM tyramine
7.2
1-hydroxy-3-(4-methoxyphenyl)guanidine
-
pH 6.0, 28°C, 5.0 mM tyramine
12.2
3-Phenylpropylamine
-
-
20.4
3-Phenylpropylamine
-
-
0.6
ascorbate
-
in the absence of Cu2+
0.93
ascorbate
-
at 0.05 mM tyramine, pH 6 and 35°C
1
ascorbate
-
in the presence of Cu2+
1.1
ascorbate
-
with or without Cu2+
1.98
ascorbate
-
at 0.1 mM tyramine, pH 6 and 35°C
5.6
ascorbate
-
at 0.3 mM tyramine, pH 6 and 35°C
16
ascorbate
-
at 0.7 mM tyramine, pH 6 and 35°C
0.0906
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
0.145
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
0.177
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.119 mM O2, pH 6 and 35°C
0.178
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.215 mM O2, pH 6 and 35°C
0.193
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 1.039 mM O2, pH 6 and 35°C
0.203
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.587 mM O2, pH 6 and 35°C
0.231
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.056 mM O2, pH 6 and 35°C
0.233
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
0.245
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
0.257
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.110 mM O2, pH 6 and 35°C
0.316
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.598 mM O2, pH 6 and 35°C
0.328
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.416 mM O2, pH 6 and 35°C
0.341
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.063 mM O2, pH 6 and 35°C
0.14
O2
-
in presence of tyramine
2.8
O2
-
in the presence of p-hydroxybenzyl cyanide
17.2
phenyl 2-aminoethyl sulfide
-
-
26.5
phenyl 2-aminoethyl sulfide
-
-
7.4
phenylacetaldehyde
-
-
7.9
phenylacetaldehyde
-
-
0.0252
tyramine
-
at 2 mM ascorbate, pH 6 and 35°C
0.0876
tyramine
-
at 10 mM ascorbate, 0.212 mM O2, pH 6 and 35°C
0.088
tyramine
-
at 10 mM ascorbate, pH 6 and 35°C
0.094
tyramine
-
at 10 mM ascorbate, 0.058 mM O2, pH 6 and 35°C
0.096
tyramine
-
at 4 mM ascorbate, pH 6 and 35°C
0.0976
tyramine
-
at 10 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
0.098
tyramine
-
at 10 mM ascorbate, 0.512 mM O2, pH 6 and 35°C
0.113
tyramine
-
at 10 mM ascorbate, 0.103 mM O2, pH 6 and 35°C
0.159
tyramine
-
at 10 mM ascorbate, 0.885 mM O2, pH 6 and 35°C
0.188
tyramine
-
at 50 mM ascorbate, 0.059 mM O2, pH 6 and 35°C
0.215
tyramine
-
at 50 mM ascorbate, 0.099 mM O2, pH 6 and 35°C
0.23
tyramine
-
at 50 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
0.235
tyramine
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
0.235
tyramine
-
at 50 mM ascorbate, pH 6 and 35°C
0.242
tyramine
-
at 50 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
0.256
tyramine
-
at 50 mM ascorbate, 0.608 mM O2, pH 6 and 35°C
0.265
tyramine
-
at 200 mM ascorbate, pH 6 and 35°C
0.367
tyramine
-
at 100 mM ascorbate, pH 6 and 35°C
0.387
tyramine
-
at 50 mM ascorbate, 0.854 mM O2, pH 6 and 35°C
0.5 - 2
tyramine
-
enzyme from serum of 5-weeks-old rats, at 37°C, pH not specified in the publication
0.79
tyramine
-
enzyme from serum of 2-weeks-old rats, at 37°C, pH not specified in the publication
0.92
tyramine
-
enzyme from serum of 8-weeks-old rats, at 37°C, pH not specified in the publication
1.22
tyramine
-
enzyme from serum of 1-weeks-old rats, at 37°C, pH not specified in the publication
1.37
tyramine
-
enzyme from serum of 12-weeks-old rats, at 37°C, pH not specified in the publication
1.6
tyramine
-
enzyme from serum of 15-weeks-old rats, at 37°C, pH not specified in the publication
1.66
tyramine
-
deglycosylated enzyme
2.1
tyramine
-
enzyme from serum of 27-weeks-old rats, at 37°C, pH not specified in the publication
2.17
tyramine
-
native enzyme
additional information
additional information
-
Km of ascorbate, tyramine and O2 as a function of pH and fumarate activation
-
additional information
additional information
-
Km of benzyl cyanide analogs with or without 6% dimethylformamide
-
additional information
additional information
-
comparison of Km of native enzyme and dimeric and tetrameric species after treatment with dithiothreitol and iodoacetamide
-
additional information
additional information
-
Km of N,N-dimethyl-1,4-phenylenediamine and ascorbic acid derivatives
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4.95 - 39.4
beta,beta-dideuterated tyramine
0.55
ascorbate
Drosophila sp. (in: flies)
-
at 0.7 mM tyramine, pH 6 and 35°C
0.8
ascorbate
Drosophila sp. (in: flies)
-
at 0.3 mM tyramine, pH 6 and 35°C
1.14
ascorbate
Drosophila sp. (in: flies)
-
at 0.1 mM tyramine, pH 6 and 35°C
1.38
ascorbate
Drosophila sp. (in: flies)
-
at 0.05 mM tyramine, pH 6 and 35°C
4.95
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.056 mM O2, pH 6 and 35°C
5.8
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.063 mM O2, pH 6 and 35°C
9.6
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.110 mM O2, pH 6 and 35°C
10.9
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.119 mM O2, pH 6 and 35°C
13.5
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
14.3
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.215 mM O2, pH 6 and 35°C
19.4
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
19.4
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.416 mM O2, pH 6 and 35°C
20.1
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.587 mM O2, pH 6 and 35°C
24.6
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.598 mM O2, pH 6 and 35°C
29.2
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
38.6
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 1.039 mM O2, pH 6 and 35°C
39.4
beta,beta-dideuterated tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
15.4
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.059 mM O2, pH 6 and 35°C
20.7
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.058 mM O2, pH 6 and 35°C
25.5
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.103 mM O2, pH 6 and 35°C
27.2
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.099 mM O2, pH 6 and 35°C
31.9
tyramine
Drosophila sp. (in: flies)
-
at 200 mM ascorbate, pH 6 and 35°C
32.4
tyramine
Drosophila sp. (in: flies)
-
at 100 mM ascorbate, pH 6 and 35°C
33
tyramine
Drosophila sp. (in: flies)
-
at 4 mM ascorbate, pH 6 and 35°C
37.8
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
37.8
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, pH 6 and 35°C
44.7
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.212 mM O2, pH 6 and 35°C
45
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, pH 6 and 35°C
47.7
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
48.2
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.854 mM O2, pH 6 and 35°C
52
tyramine
Drosophila sp. (in: flies)
-
at 2 mM ascorbate, pH 6 and 35°C
58.1
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.512 mM O2, pH 6 and 35°C
58.6
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 0.608 mM O2, pH 6 and 35°C
61.7
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 0.885 mM O2, pH 6 and 35°C
70
tyramine
Drosophila sp. (in: flies)
-
at 50 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
74.3
tyramine
Drosophila sp. (in: flies)
-
at 10 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0057
1(2H)-Phthalazine hydrazone
-
-
4.6
1-(3,4-Dihydroxybenzyl)imidazole
-
-
2.9
1-(4-Hydroxybenzyl)-2-methylimidazole
-
-
0.16
1-(4-Hydroxybenzyl)pyrazole
-
-
11.9
1-Benzylimidazole
-
-
0.0009 - 0.8
1-Isoquinolinecarboxylic acid
13
1-Phenyl-1-aminomethylethene
-
-
0.0019
2(1H)-Pyridinone hydrazone
-
-
0.021
2,2'-Bi-(1H)-imidazole
-
-
0.52
2-(4-Hydroxyphenyl)prop-2-enylamine
-
-
4.9
2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
-
4.7
2-Phenylprop-2-enylamine
-
-
2.5
4-Hydroxy-alpha-methylstyrene
-
-
2.3
4-hydroxybenzaldehyde
-
-
1.25 - 7.8
beta,beta-dideuterated tyramine
26
beta,beta-difluorophenethylamine
-
pH 6.0, 35°C
0.015 - 0.208
beta-ethynytyramine
1.1
N-Phenylethylenediamine
-
-
0.14
Quinoline-2-carboxylic acid
-
-
additional information
additional information
-
0.0009
1-Isoquinolinecarboxylic acid
-
-
0.8
1-Isoquinolinecarboxylic acid
-
-
0.0011
ascorbate
-
at 0.05 mM tyramine, pH 6 and 35°C
0.0018
ascorbate
-
at 0.1 mM tyramine, pH 6 and 35°C
1.25
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.587 mM O2, pH 6 and 35°C
2
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
2.1
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.215 mM O2, pH 6 and 35°C
2.4
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
2.8
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.119 mM O2, pH 6 and 35°C
2.8
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.416 mM O2, pH 6 and 35°C
2.86
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 1.039 mM O2, pH 6 and 35°C
3.3
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.598 mM O2, pH 6 and 35°C
3.35
beta,beta-dideuterated tyramine
-
at 10 mM ascorbate, 0.056 mM O2, pH 6 and 35°C
4
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.907 mM O2, pH 6 and 35°C
6
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.110 mM O2, pH 6 and 35°C
7.4
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.063 mM O2, pH 6 and 35°C
7.8
beta,beta-dideuterated tyramine
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
0.015
beta-ethynytyramine
-
R,S-1
0.057
beta-ethynytyramine
-
S-1, in the presence of ascorbate
0.208
beta-ethynytyramine
-
S-1
0.37
hydroquinone
-
pH: 4.9
1.05
hydroquinone
-
pH: 5.9
0.98
tyramine
-
at 10 mM ascorbate, 0.885 mM O2, pH 6 and 35°C
1.23
tyramine
-
at 10 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
1.3
tyramine
-
at 4 mM ascorbate, pH 6 and 35°C
1.57
tyramine
-
at 50 mM ascorbate, 0.854 mM O2, pH 6 and 35°C
1.9
tyramine
-
at 50 mM ascorbate, 0.608 mM O2, pH 6 and 35°C
2.03
tyramine
-
at 50 mM ascorbate, 1.04 mM O2, pH 6 and 35°C
2.07
tyramine
-
at 10 mM ascorbate, 0.512 mM O2, pH 6 and 35°C
2.1
tyramine
-
at 2 mM ascorbate, pH 6 and 35°C
2.46
tyramine
-
at 50 mM ascorbate, 0.395 mM O2, pH 6 and 35°C
3.33
tyramine
-
at 10 mM ascorbate, 0.103 mM O2, pH 6 and 35°C
3.5
tyramine
-
at 10 mM ascorbate, 0.212 mM O2, pH 6 and 35°C
3.5
tyramine
-
at 10 mM ascorbate, pH 6 and 35°C
3.6
tyramine
-
at 100 mM ascorbate, pH 6 and 35°C
3.97
tyramine
-
at 50 mM ascorbate, 0.099 mM O2, pH 6 and 35°C
4.15
tyramine
-
at 50 mM ascorbate, 0.214 mM O2, pH 6 and 35°C
4.15
tyramine
-
at 50 mM ascorbate, pH 6 and 35°C
7.82
tyramine
-
at 10 mM ascorbate, 0.058 mM O2, pH 6 and 35°C
10.2
tyramine
-
at 50 mM ascorbate, 0.059 mM O2, pH 6 and 35°C
10.3
tyramine
-
at 200 mM ascorbate, pH 6 and 35°C
additional information
additional information
-
-
-
additional information
additional information
-
KI as function of pH and fumarate activation
-
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Rattus norvegicus
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Oyarce, A.M.; Steveson, T.C.; Jin, L.; Eipper, B.A.
Dopamine beta-monooxygenase signal/anchor sequence alters trafficking of peptidylglycine alpha-hydroxylating monooxygenase
J. Biol. Chem.
276
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2001
Rattus norvegicus
brenda
Mitrochkine, A.A.; Eydoux, E.; Gil, G.; Reglier, M.
Aminoindanes in oxygen atom transfer reactions, 1: Enzymatic hydroxylation by dopamine beta-hydroxylase
Eur. J. Org. Chem.
1998
1171-1176
1998
Bos taurus
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brenda
Slama, P.; Boucher, J.L.; Reglier, M.
Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase
Biochem. Biophys. Res. Commun.
316
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2004
Bos taurus
brenda
Terland, O.; Flatmark, T.
Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase
Biochem. J.
369
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2003
Bos taurus
brenda
Seike, Y.; Takeuchi, F.; Tsubaki, M.
Reversely-oriented cytochrome b561 in reconstituted vesicles catalyzes transmembrane electron transfer and supports extravesicular dopamine beta-hydroxylase activity
J. Biochem.
134
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2003
Bos taurus
brenda
Hassan, S.; Duong, B.; Kim, K.S.; Miles, M.F.
Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase
J. Biol. Chem.
278
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2003
Homo sapiens
brenda
Evans, J.P.; Ahn, K.; Klinman, J.P.
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase: Implications for the reactive oxygen species
J. Biol. Chem.
278
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2003
Bos taurus
brenda
Wimalasena, D.S.; Wimalasena, K.
Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts
J. Biol. Chem.
279
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2004
Bos taurus
brenda
Paclt, I.; Koudelova, J.
Changes of dopamine-beta-hydroxylase activity during ontogenesis in healthy subjects and in an experimental model (rats)
Physiol. Res.
53
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2004
Homo sapiens, Rattus norvegicus
brenda
Grabowska, M.; Schlegel-Zawadzka, M.; Papp, M.; Nowak, G.
Effect of imipramine treatment on plasma dopamine beta-hydroxylase activity in chronic mild stress in rats
Pol. J. Pharmacol.
56
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2004
Rattus norvegicus
brenda
Garcia, G.B.; Konjuh, C.; Duffard, R.O.; Evangelista de Duffard, A.M.
Dopamine-beta-hydroxylase immunohistochemical study in the locus coeruleus of neonate rats exposed to 2,4-dichlorophenoxyacetic acid through mothers milk
Drug Chem. Toxicol.
29
435-442
2006
Rattus norvegicus
brenda
Abe, M.; Wu, Z.; Yamamoto, M.; Jin, J.J.; Tabara, Y.; Mogi, M.; Kohara, K.; Miki, T.; Nakura, J.
Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese
Hypertens. Res.
28
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2005
Homo sapiens
brenda
Klinman, J.P.
The copper-enzyme family of dopamine b-monooxygenase and peptidylglycine a-hydroxylating monooxygenase: Resolving the chemical pathway for substrate hydroxylation
J. Biol. Chem.
281
3013-3016
2006
Homo sapiens
brenda
Grabowska, M.; Przyslawski, J.; Boleslawska, I.; Schlegel-Zawadzka, M.
Status of serum copper and dopamine beta-hydroxylase (DBH) activity in healthy population
Metal Ions in Biology and Medicine
9
525-529
2006
Rattus norvegicus
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brenda
Ranson, R.N.; Santer, R.M.; Watson, A.H.
The relationship between serotonin, dopamine beta hydroxylase and GABA immunoreactive inputs and spinal preganglionic neurones projecting to the major pelvic ganglion of Wistar rats
Neuroscience
141
1935-1949
2006
Rattus norvegicus
brenda
Mustapic, M.; Pivac, N.; Kozaric-Kovacic, D.; Dezeljin, M.; Cubells, J.F.; Mueck-Seler, D.
Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
1087-1089
2007
Homo sapiens
brenda
Bhaduri, N.; Mukhopadhyay, K.
Correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene: a study on Eastern Indian population
Cell. Mol. Neurobiol.
28
343-350
2008
Homo sapiens
brenda
Ando, H.; Tomida, M.; Inoue, K.; Asanuma, N.
Dopamine beta-hydroxylase like immunoreactive cells in the frog taste disc
Chem. Senses
32
825-832
2007
Lithobates catesbeianus
brenda
Tang, Y.L.; Epstein, M.P.; Anderson, G.M.; Zabetian, C.P.; Cubells, J.F.
Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans
Eur. J. Hum. Genet.
15
878-883
2007
Homo sapiens
brenda
Hong, S.J.; Choi, H.J.; Hong, S.; Huh, Y.; Chae, H.; Kim, K.S.
Transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase by interacting with Sp1 and AP4
Neurochem. Res.
33
1821-1831
2008
Coturnix japonica, Homo sapiens
brenda
Kvetnansky, R.; Krizanova, O.; Tillinger, A.; Sabban, E.L.; Thomas, S.A.; Kubovcakova, L.
Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress
Ann. N. Y. Acad. Sci.
1148
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2008
Mus musculus
brenda
Guindalini, C.; Laranjeira, R.; Collier, D.; Messas, G.; Vallada, H.; Breen, G.
Dopamine-beta hydroxylase polymorphism and cocaine addiction
Behav. Brain Funct.
4
1-4
2008
Homo sapiens
brenda
Hong, S.J.; Chae, H.; Lardaro, T.; Hong, S.; Kim, K.S.
Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b
Biochem. Biophys. Res. Commun.
368
650-655
2008
Gallus gallus
brenda
Nelson, K.T.; Prohaska, J.R.
Copper deficiency in rodents alters dopamine beta-mono-oxygenase activity, mRNA and protein level
Br. J. Nutr.
102
18-28
2009
Mus musculus, Rattus norvegicus
brenda
Cheng, S.Y.; Serova, L.I.; Glazkova, D.; Sabban, E.L.
Regulation of rat dopamine beta-hydroxylase gene transcription by early growth response gene 1 (Egr1)
Brain Res.
1193
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2008
Rattus norvegicus
brenda
Nagatsu, T.
Simple photometric assay of dopamine-beta-hydroxylase activity in human blood: Useful in clinical chemistry
Clin. Chem.
55
193-194
2009
Homo sapiens
brenda
Parlato, R.; Otto, C.; Tuckermann, J.; Stotz, S.; Kaden, S.; Groene, H.J.; Unsicker, K.; Schuetz, G.
Conditional inactivation of glucocorticoid receptor gene in dopamine-beta-hydroxylase cells impairs chromaffin cell survival
Endocrinology
150
1775-1781
2009
Mus musculus
brenda
Hess, C.; McGuirl, M.; Klinman, J.
Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase
J. Biol. Chem.
283
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2008
Drosophila melanogaster
brenda
Fan, Y.; Huang, J.; Kieran, N.; Zhu, M.Y.
Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells
J. Neurochem.
110
1502-1513
2009
Homo sapiens
brenda
Zhou, Z.; Wang, L.; Yang, J.; Zhang, H.; Kong, P.; Wang, M.; Qiu, L.; Song, L.
A dopamine beta hydroxylase from Chlamys farreri and its induced mRNA expression in the haemocytes after LPS stimulation
Fish Shellfish Immunol.
30
154-162
2011
Azumapecten farreri (E9JGS5), Azumapecten farreri
brenda
Kim, C.H.; Leung, A.; Huh, Y.H.; Yang, E.; Kim, D.J.; Leblanc, P.; Ryu, H.; Kim, K.; Kim, D.W.; Garland, E.M.; Raj, S.R.; Biaggioni, I.; Robertson, D.; Kim, K.S.
Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase
J. Biol. Chem.
286
9196-9204
2011
Homo sapiens
brenda
Rahman, M.K.; Choudhary, M.I.; Islam, M.R.; Hafizur, R.M.
Developmental changes of catecholamine-mediating enzyme - dopamine-beta-hydroxylase and its cofactors in central and peripheral tissues and serum of long-evans rats
Int. J. Biomed. Sci.
8
194-203
2012
Rattus norvegicus
brenda
Kapoor, A.; Shandilya, M.; Kundu, S.
Structural insight of dopamine beta-hydroxylase, a drug target for complex traits, and functional significance of exonic single nucleotide polymorphisms
PLoS ONE
6
e26509
2011
Homo sapiens (P09172)
brenda
Kato, K.; Fushuku, S.; Yamamoto, Y.
Age-related changes in immunoreactivity for dopamine beta-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats
Auton. Neurosci.
205
50-56
2017
Rattus norvegicus (Q05754), Rattus norvegicus Wistar Kyoto (Q05754)
brenda
Xu, Q.; Song, Y.; Liu, R.; Chen, Y.; Zhang, Y.; Li, Y.; Zhao, W.; Chang, G.; Chen, G.
The dopamine beta-hydroxylase gene in Chinese goose (Anas cygnoides) cloning, characterization, and expression during the reproductive cycle
BMC Genet.
17
48
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Anser cygnoides domesticus (A0A140GN70)
brenda
Kim, S.; Park, J.; Moon, J.; Choi, H.
Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine beta-hydroxylase and is associated with abnormal adaptive responses to immobilization stress
Exp. Neurol.
252
63-74
2014
Homo sapiens (P09172), Mus musculus (Q64237)
brenda
Cheng, W.; Ka, Y.W.; Chang, C.C.
Dopamine beta-hydroxylase participate in the immunoendocrine responses of hypothermal stressed white shrimp, Litopenaeus vannamei
Fish Shellfish Immunol.
59
166-178
2016
Penaeus vannamei (A0A1I9LDK0), Penaeus vannamei
brenda
Cheng, W.; Ka, Y.W.; Chang, C.C.
Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei
Fish Shellfish Immunol.
68
92-101
2017
Penaeus vannamei (A0A1I9LDK0), Penaeus vannamei
brenda
Punchaichira, T.J.; Dey, S.K.; Mukhopadhyay, A.; Kundu, S.; Thelma, B.K.
Characterization of SNPs in the dopamine-beta-hydroxylase gene providing new insights into its structure-function relationship
Neurogenetics
18
155-168
2017
Homo sapiens (P09172)
brenda
Vendelboe, T.V.; Harris, P.; Zhao, Y.; Walter, T.S.; Harlos, K.; El Omari, K.; Christensen, H.E.
The crystal structure of human dopamine beta-hydroxylase at 2.9 A resolution
Sci. Adv.
2
e1500980
2016
Homo sapiens (P09172)
brenda