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Information on EC 1.1.1.428 - 4-methylthio 2-oxobutanoate reductase (NADH)

for references in articles please use BRENDA:EC1.1.1.428
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EC Tree
IUBMB Comments
The substrate of this enzyme is formed as an intermediate during L-methionine salvage from S-methyl-5'-thioadenosine, which is formed during the biosynthesis of polyamines. The human enzyme also functions as a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes, thus providing a link between gene repression and the methionine salvage pathway. A similar, but NADP-specific, enzyme is involved in dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton.
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The expected taxonomic range for this enzyme is: Homo sapiens
Reaction Schemes
Synonyms
ctbp2, ctbp1, c-terminal binding protein 1, c-terminal-binding protein 2, c-terminal-binding protein 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+ = 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+
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