5.6.2.3: DNA 5'-3' helicase

This is an abbreviated version!
For detailed information about DNA 5'-3' helicase, go to the full flat file.

Reaction

Couples ATP hydroysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand. =

Synonyms

5' to 3' DNA helicase, 5'-3' DNA helicase, ATP-dependent DNA helicase, ATP-dependent helicase, ATP-dependent RecD-like DNA helicase, BACH1, BACH1 helicase, BcMCM, BLM protein, BRCA1-associated C-terminal helicase, C10orf2, CeWRN-1, ChlR1, ChlR1 helicase, Dbp9p, dda, dda DNA helicase, dda protein, DDB0187832, DDX11, delta helicase, dheI I, dhel 11, Dmel_CG5924, DNA helicase, DNA helicase A, DNA helicase B, DNA helicase E, DNA helicase HELQ, DNA helicase II, DNA helicase III, DNA helicase VI, DNA repair helicase FancJ, DNA repair helicases XPD, Dna2Pho, dnaB, DnaB class helicase, DnaB helicase, DnaB helicase E1, dnaB replication protein, DnaB type helicase, EC 3.6.4.12, FacXPD, FANCJ, Fanconi Anemia Group J Protein, G4-binding helicase, HCoV helicase, HCoV SF1 helicase, HDHB, Hel E, HELB, helicase DnaB, helicase domain of bacteriophage T7 gene 4 protein helicase, helicase HDH IV, helicase POLQ-like, helicase XPD, HELQ, HerA, HerA bipolar helicase, HerA helicase, hHcsA, Hjm/Hel308A DNA helicase, Hmi1p, Holliday junction helicase, hPif1, human DNA helicase B, human mitochondrial DNA helicase, MCM helicase, MCM protein, mitochondrial DNA helicase, mitochondrial DNA replicative helicase Twinkle, mitochondrial replicative DNA helicase, MPH1, MtbDnaB, mtDNA helicase, nsp13, PcrA, PcrA helicase, PcrASpn, PfDH A, Pfh1, Pfh1 DNA helicase, Pfh1p, PH0109, PIF1, Pif1 DNA helicase, Pif1 family helicase, PIF1 helicase, RecD2, replication fork helicase, replicative DNA helicase, replicative mtDNA helicase, Rho, RNA/DNA helicase, Rrm3p, Rtel1, RuvB1, Saci_0192, SaXPD, scHelI, SEN1, Sen1p, SF1 helicase, STK_05900, STK_13070, StoHjm, taXPD, TbPIF1, Tk-Upf1, TK0178, TK_RS00875, TWINKLE, TWINKLE DNA helicase, Twinkle homologue, Twinkle protein, Twm1, TWNK, UvrD, WCGp80, Wildcat Gp80, XDP, xeroderma pigmentosum group D DNA helicase, XPD, XPD helicase

ECTree

     5 Isomerases

         5.6 Isomerases altering macromolecular conformation

             5.6.2 Enzymes altering nucleic acid conformation

                5.6.2.3 DNA 5'-3' helicase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
40	Activating Compound
31	AA Sequence
2	Application
43	Cloned(Commentary)
25	Cofactor
7	Crystallization (Commentary)
2498	Disease/ Diagnostics
1	Expression
101	General Information
1	IC50 Value
40	Inhibitors
22	kcat/KM [mM/s]
49	KM Value [mM]
42	Localization
58	Metals/Ions
24	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
373	Organism
24	pH Optimum
2	pH Range
1	pH Stability
2	Posttranslational Modification
96	Protein Variants
45	Purification (Commentary)
1	Reaction
104	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
41	Subunits
230	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
38	Turnover Number [1/s]