5.6.2.2: DNA topoisomerase (ATP-hydrolysing)

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For detailed information about DNA topoisomerase (ATP-hydrolysing), go to the full flat file.

Reaction

ATP-dependent breakage, passage and rejoining of double-stranded DNA =

Synonyms

ATP-dependent topoisomerase, ATP-dependent type I 5'-topoisomerase, ATPase, deoxyribonucleic acid topoisomerase IIalpha, DNA gyrase, DNA gyrase B, DNA gyrase-B, DNA gyrB, DNA Top IIbeta, DNA Topo II, DNA topo IIalpha, DNA topoisomerase 2alpha, DNA topoisomerase II, DNA topoisomerase II alpha, DNA topoisomerase II beta, DNA topoisomerase IIalpha, DNA topoisomerase IIbeta, DNA topoisomerase IV, DNA topoisomerase type II, DNA topoisomerase VI, DNA topoisomerase VIII, DNA topoisomeraseIIalpha, DNA topoisomerases II, DNA-topoisomerase II, DNA-topoisomerase II-alpha, DNATop2A, EC 5.99.1.3, GyrA, gyrase, GyrB, gyrB ATPase, hTopoIIalpha, Isomerase, deoxyribonucleate topo-, II, microrchidia protein, MmT6, MORC1, More, NP170 proteins, Nuclear proteins 170,000-mol.wt., pP1192R, Protein Gp39, Protein Gp52, Protein Gp60, Proteins , NP170 (specific proteins and subclasses nuclear protein, 170,000-mol.-wt.), PsTopII, Reverse gyrase, SsT6, tIIalpha, Top2, top2a, Top2alpha, Top2b, TOP2mt, top6B, TopII, topIIalpha, topo II, topo II alpha, topo II-alpha, Topo IIA, Topo IIalpha, Topo IIbeta, topo IV, topo VI, topo-IIalpha, topo2alpha, TOPOII, topoIIalpha, topoIIbeta, topoisomerase 2 alpha, Topoisomerase II, topoisomerase II alpha, topoisomerase IIA, topoisomerase IIalpha, topoisomerase IIbeta, topoisomerase IV, Topoisomerase type II, topoisomerase VI, topoisomerase-II, topoIV, TopoNM, toposiomerase II, topoVI, topoVI-B, topR, TopR1, TopR2, type 2 DNA topoisomerase, type I topoisomerase, type II DNA topoisomerase, type II topoisomerase, Type II-DNA-topoisomerase, type IIA topoisomerase, type IIalpha DNA topoisomerase, type IIB topoisomerase, type-II topoisomerase

ECTree

     5 Isomerases

         5.6 Isomerases altering macromolecular conformation

             5.6.2 Enzymes altering nucleic acid conformation

                5.6.2.2 DNA topoisomerase (ATP-hydrolysing)

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Results	in table
61	Activating Compound
197324	AA Sequence
23	Application
2	CAS Registry Number
74	Cloned(Commentary)
114	Cofactor
12	Crystallization (Commentary)
18303	Disease/ Diagnostics
3	Expression
62	General Information
2	General Stability
230	IC50 Value
1552	Inhibitors
9	kcat/KM [mM/s]
4	Ki Value [mM]
39	KM Value [mM]
104	Localization
171	Metals/Ions
71	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
925	Organism
1	Oxidation Stability
95	PDB ID
114	pH Optimum
4	pH Range
1	pH Stability
10	Posttranslational Modification
113	Protein Variants
67	Purification (Commentary)
17	Reaction
1	Reaction Type
447	Reference
305	Source Tissue
23	Specific Activity [micromol/min/mg]
6	Storage Stability
724	Substrates and Products (Substrate)
92	Subunits
491	Synonyms
1	Systematic Name
123	Temperature Optimum [°C]
8	Temperature Range [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]