3.4.24.86: ADAM 17 endopeptidase
This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.86
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3.4.24.86
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adam10
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ectodomains
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sheddase
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metalloproteinases
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endothelial
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phorbol
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sirna
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amyloid
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egf
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alzheimer
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notch
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angiotensin
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membrane-anchored
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arthritis
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amphiregulin
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ace2
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hb-egf
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hydroxamate
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timp-3
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heparin-binding
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l-selectin
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trans-signaling
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angiotensin-converting
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covid-19
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alpha-secretase
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mmp-2
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sars-cov-2
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egf-like
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juxtamembrane
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medicine
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prodomains
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furin
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secretase
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tgf-alpha
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membrane-proximal
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tmprss2
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sil-6r
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non-amyloidogenic
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cxcl16
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rhomboid
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epiregulin
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gamma-secretase
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neuregulins
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molecular biology
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adamalysins
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metzincins
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membrane-tethered
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fractalkine
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betacellulin
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marimastat
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analysis
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egfr-dependent
- 3.4.24.86
- adam10
- ectodomains
- sheddase
- metalloproteinases
- endothelial
-
phorbol
- sirna
-
amyloid
- egf
- alzheimer
- notch
- angiotensin
-
membrane-anchored
- arthritis
- amphiregulin
- ace2
- hb-egf
- hydroxamate
- timp-3
-
heparin-binding
- l-selectin
-
trans-signaling
-
angiotensin-converting
- covid-19
- alpha-secretase
- mmp-2
- sars-cov-2
-
egf-like
-
juxtamembrane
- medicine
- prodomains
- furin
-
secretase
- tgf-alpha
-
membrane-proximal
- tmprss2
-
sil-6r
-
non-amyloidogenic
- cxcl16
- rhomboid
- epiregulin
- gamma-secretase
- neuregulins
- molecular biology
- adamalysins
-
metzincins
-
membrane-tethered
- fractalkine
- betacellulin
- marimastat
- analysis
-
egfr-dependent
Reaction
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =
Synonyms
(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme