3.1.99.B1: flap endonuclease-1

This is an abbreviated version!
For detailed information about flap endonuclease-1, go to the full flat file.

Reaction

endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick =

Synonyms

AfFEN, Dna2, FEN, FEN-1, FEN1, FEN1 endonuclease, flap endonuclease, flap endonuclease 1, flap endonuclease-1, hFEN1, More, ribonuclease H, RNase H, RNH, T4 RNase H, T5 flap endonuclease, T5FEN

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

            

                3.1.99.B1 flap endonuclease-1

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Results	in table
1	Activating Compound
10	AA Sequence
1	Application
18	Cloned(Commentary)
11	Crystallization (Commentary)
247	Disease/ Diagnostics
11	General Information
13	IC50 Value
15	Inhibitors
2	kcat/KM [mM/s]
8	KM Value [mM]
22	Metals/Ions
2	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
39	Organism
14	pH Optimum
6	pH Range
1	pI Value
92	Protein Variants
19	Purification (Commentary)
3	Reaction
35	Reference
1	Source Tissue
2	Storage Stability
35	Substrates and Products (Substrate)
4	Subunits
51	Synonyms
16	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
4	Turnover Number [1/s]